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40results about How to "Good slow and controlled release effect" patented technology
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Chinese herbal medicine preparation
ActiveCN104117083AHas a long-lasting sustained-release effectStable blood concentrationPillowsPowder deliveryMedicineCurative effect
The invention relates to a pharmaceutical composition which is stored in bedding articles and capable of enabling people to obtain curative effects of tranquilizing and allaying excitement. The Chinese herbal medicine preparation is powder or granule which is prepared by taking one or more of lavender, twinings, jasmine flower and liquorice as materials. According to the invention, a scientific process is adopted for preparing one or more of lavender powder, twinings powder, jasmine flower powder and liquorice powder into powder with a proper grain size or into a similar pharmaceutical granule. The substances with effects of tranquilizing and allaying excitement have effects of slowly releasing for a long time.
Owner:汪建
Composite drug carried microsphere, minocycline hydrochloride nano controlled-release composite drug carried microsphere system and preparation method thereof
InactiveCN101836961ALow toxicityGood slow releaseAntibacterial agentsTetracycline active ingredientsMicrosphereCholesterol
The invention relates to a composite drug carried microsphere, a minocycline hydrochloride nano controlled-release composite drug carried microsphere system and a preparation method thereof. A drug carried system with a nuclear shell structure is formed by embedding minocycline hydrochloride inside a poly D,L-lactide-co-glycolic acid polymer microsphere and covering a cationic polymeric liposome prepared from O-QACMC modified by polyethylene glycol, O-QACMC and cholesterol outside the poly D, L-lactide-co-glycolic acid polymer microsphere; and the composite drug carried microsphere system covered and carried with the minocycline hydrochloride has the grain diameter ranging from 340 nm to 400 nm and positive surface Zeta electric potential. The composite drug carried microsphere system can be remained in a water solution for at least 2 months, has high entrapment rate reaching larger than 90 percent on drugs and strong drug carrying capacity reaching 9 percent. The minocycline hydrochloride nano controlled-release composite drug carried microsphere system has the characteristics of uniform and controllable grain diameter, good preparation stability, simple preparation process, high drug carrying rate, favorable controlled release function, and the like, and is suitable for batch production.
Owner:TIANJIN UNIV
Modified biological wax coated controlled-release fertilizer and preparation method thereof
ActiveCN106380315ASimple production processLess investmentOrganic fertilisersFertilizer mixturesWaxControl release
The invention discloses a modified biological wax coated controlled-release fertilizer and a preparation method thereof; the preparation method comprises the steps: firstly, melting biological wax, then adding a modifier, and modifying to change the melting point and toughness; then taking the modified biological wax as a coating material to coat the surface of 2-5 mm fertilizer particles, and coating for a plurality of times according to different melting points; and finally, cooling to prepare the coated controlled-release fertilizer, wherein the weight of the coating material accounts for 1%-10% of the total weight of the fertilizer. Compared with ordinary controlled-release fertilizer, the modified biological wax coated controlled-release fertilizer has the advantages of environmental-protection and no-toxic film material, simple production process, low investment, low energy consumption in the production process and the like.
Owner:SHANDONG AGRI UNIV FERTILIZER TECH CO LTD
Ecological rice field compound microbial fertilizer and preparation method thereof
PendingCN106800466AProlong the action timeImprove lodging resistanceAnimal corpse fertilisersUrea compound fertilisersMicroecosystemMicrobial agent
The invention provides ecological rice field compound microbial fertilizer and a preparation method thereof and relates to the technical field of fertilizer. The ecological rice field compound microbial fertilizer is prepared from the following components in parts by mass: 5 to 15 parts of humic acid, 10 to 20 parts of bementite, 3 to 7 parts of medical stone, 5 to 15 parts of shell powder, 5 to 15 parts of fishbone dust, 35 to 45 parts of urea, 10 to 20 parts of potassium chloride, 0.5 to 1.5 parts of compound microbial agent and 0.5 to 1.5 parts of chitosan. The ecological rice field compound microbial fertilizer solves the technical problem that rice fertilizer application in a planting, breeding and cocuiture process of an existing ecological rice field has harm to growth and quality of aquatic products, achieves the technical effects of guaranteeing rice nutrient supply balance, achieving good quality and high yield of rice, purifying water quality, guaranteeing normal growth of the aquatic products and constructing a dynamic micro ecosystem of the ecological rice field, further can reduce fertilizer applying times at the same time, prolongs fertilizer action time and reduces economical and labor invest of producers.
Owner:ZHENGZHOU YONGFENG BIOLOGICAL FERTILIZER IND CO LTD
Producing process of sulfur-coated urea sustained and controlled release synergistic fertilizer
InactiveCN104108977AReduce manufacturing costImprove Nutrients and Comprehensive Utilization EfficiencyUrea compound fertilisersFertilizer mixturesCoated ureaParaffin wax
The invention discloses a producing process of a sulfur-coated urea sustained and controlled release synergistic fertilizer. The producing process comprises the steps of firstly carrying out coating treatment with molten liquid sulfur, and then carrying out secondary coating mouth-sealing treatment with molten paraffin wax. The producing process has the advantages that the coating material is low in cost, the production cost is reduced, the sustained and controlled release effect is good, and the problem that a traditional coated sustained / controlled release fertilizer has secondary pollution on soil is completely solved.
Owner:云中英
Frontal polymerization preparation method for thymopentin molecular imprinted hydrogel
The invention relates to a frontal polymerization preparation method for a thymopentin molecular imprinted hydrogel which is prepared from the raw materials in percentage by mass: 4.33%-11.94% of thymopentin, 10.00%-36.44% of N-isopropylacrylamide, 5.88%-21.86% of acrylic acid, 0.36%-0.74% of N, N'-methylenebisacrylamide, 9.92%-33.58% of choline chloride and 30.12%-53.68% of ethylene glycol. By using the frontal polymerization preparation method, a molecular imprinted hydrogel sustained-release material is prepared by taking bioactive molecule thymopentin as a template and a green solvent DESsystem as a pore-foaming agent, and the molecular imprinted hydrogel sustained-release material serving as a drug carrier is stable in physical and chemical properties and obvious in imprinting effect; the molecular imprinted hydrogel sustained-release material is large in drug loading capacity and has an obvious sustained-release effect for the template molecule thymopentin; and compared with a thermal polymerization imprinted hydrogel, the molecular imprinted hydrogel sustained-release material is capable of prolonging the in-vivo metabolism time of a drug and increasing the biological availability of the drug.
Owner:TIANJIN MEDICAL UNIV
Hydrophobic pesticide preparation containing microcapsules and preparation method of hydrophobic pesticide preparation containing microcapsules
InactiveCN106259315AIncrease profitProlong the action timeBiocideDead animal preservationChlorpyrifosMalathion
The invention discloses a hydrophobic pesticide preparation containing microcapsules and a preparation method of the hydrophobic pesticide preparation containing the microcapsules. The type of the preparation is water emulsion and microcapsule suspending agent; the microcapsules contain core materials and wall materials; the core materials are active ingredients encapsulated in the microcapsules and are alternatively selected from the following substances: chlorpyrifos, malathion, pyraclostrobin and acetochlor, wherein the drug loading capacity is 10 to 30 percent counted by mass; the wall materials are biodegradable polymer materials and are alternatively selected from the following substances: polycaprolactone (PCL), poly lactide-glycolic acid (PLGA) copolymer and polylactic acid (PVA); active ingredients of the water emulsion are core materials which are not encapsulated in the microcapsules. According to the hydrophobic pesticide preparation disclosed by the invention, by adopting biodegradable environment-friendly polymer as the wall materials, hydrophobic pesticide is effectively coated, a significant sustained-release effect is realized, the utilization rate of pesticide is improved, the acting time of the pesticide is prolonged, the production cost is reduced, and the aims of reducing pesticide applying times and the pressure of a biological environment are achieved.
Owner:ANHUI COSTAR BIOCHEM CO LTD
Magnetization slow-release fertilizer capable of improving soil microbial ecology and preparation method thereof
InactiveCN105461443APromote photosynthesisPromote growth and developmentCalcareous fertilisersBioloigcal waste fertilisersEggshellPotassium
The invention discloses a magnetization slow-release fertilizer capable of improving soil microbial ecology and a preparation method thereof. The magnetization slow-release fertilizer capable of improving the soil microbial ecology is made from raw materials with parts by weight: egg shells 50-70, fulvic acid potassium 26-29, ammonium bicarbonate 23-26, furfural residues 260-270, grass carbon 190-210, sodium hydrogen sulfite 8-14, fly ash 100-110, pyrite ash 80-90, cassava starch 26-30, calcium acetate 4-8, composite bacterial strains 13-17 and moderate water. The magnetization slow-release fertilizer capable of improving the soil microbial ecology adds various magnetotactic microorganisms, various different kinds of beneficial magnetotactic microorganisms also exist in soils simultaneously, the magnetization slow-release fertilizer capable of improving the soil microbial ecology can affect activity of the beneficial magnetotactic microorganisms through magnetization of fertilizers by adopting organic humus in the fertilizers as a nutrient source, improves activity of proteins and enzymes, and enhances activity of microorganisms, thereby promoting organic matters in the soils to resolve, and improving the content of absorbable nutrients of crops.
Owner:ANHUI HUACHUANG MODERN AGRI TECH
Novel fertilizer synergist and preparation method thereof
InactiveCN110885278AGood slow and controlled release effectIncrease profitAgriculture gas emission reductionFertilizer mixturesSoil scienceUrease enzyme
The invention discloses a novel fertilizer synergist and a preparation method thereof, and belongs to the technical field of fertilizer preparation. The novel fertilizer synergist comprises a urease inhibitor, a nitrification inhibitor, a composite biological agent and a water-retaining agent. The synergist can reduce the loss of effective components in a fertilizer, increase the utilization rateof the fertilizer, improve the soil environment and improve the crop quality.
Owner:GUANGXI FORESTRY RES INST
Temperature-sensitive controlled-release pharmaceutical composition of taxane drugs
ActiveCN104784109AEasy to makeHigh drug loadingOrganic active ingredientsAerosol deliveryControlled releaseBeta-glycerophosphate
The invention relates to a temperature-sensitive controlled-release pharmaceutical composition of taxane drugs. Specifically speaking, the invention relates to the pharmaceutical composition which comprises taxane drugs, chitosan, sodium beta-glycerophosphate, ethanol and water, and further relates to a preparation method for the pharmaceutical composition. The pharmaceutical composition can be used for preparation of anticancer drugs. In particular, the anticancer drugs are applied to treatment of malignant tumors or prevention of recurrence after operation through a stereotaxical injection approach and can be cooperatively used with radiotherapy and traditional Chinese medicine.
Owner:王子厚
Nano pesticide for preventing and treating monochamus alternatus and pine wood nematodes
ActiveCN110786334AUniform and stable particle sizeGood dispersionBiocideNematocidesAbamectinCell wall
The invention discloses a novel nano pesticide for preventing and treating monochamus alternatus and pine wood nematodes. The novel nano pesticide is a nano pesticide preparation prepared by taking nano Cu-BTC as a carrier to load pesticide abamectin; the nano Cu-BTC serving as the carrier is uniform and stable in particle size and good in dispersity, and agglomeration is avoided; the interior ofthe nano Cu-BTC is of a porous structure, so that the nano Cu-BTC has a relatively large specific surface area, high drug loading capacity and a quite good sustained and controlled release effect. Theprepared nano pesticide preparation can penetrate through cell wall barriers of plants due to the nano size, and the pesticide is transported into barks and is used for preventing and treating monochamus alternatus and pine wood nematodes.
Owner:SHANDONG AGRICULTURAL UNIVERSITY
Dampproof easily-absorbed magnetized slow-release fertilizer and preparation method thereof
InactiveCN105461444AIncrease oxygen contentProtect healthBio-organic fraction processingMagnesium fertilisersSesamum orientalePotassium
The invention discloses a dampproof easily-absorbed magnetized slow-release fertilizer and a preparation method thereof. The dampproof easily-absorbed magnetized slow-release fertilizer is prepared from, by weight, 45-65 parts of soybean oil sediments, 35-40 parts of peat soil, 160-190 parts of sesame meal, 10-12 parts of magnesium nitrate, 26-28 parts of potassium hydrogen phosphate, 250-280 parts of Chinese medicine residues, 23-25 parts of EDTA chelate boron, 80-100 parts of flyash, 55-60 parts of iron pyrite ash, 30-35 parts of cassava starch, 5-8 parts of lime acetate, 20-24 parts of a composite bacterial strain and a proper amount of water. According to the fertilizer, raw materials contain sufficient nitrogen, phosphorus and potassium which are greatly needed by plants, meanwhile the EDTA chelate boron and chelating liquid of a coated layer are utilized, it is beneficial for the plants to absorb various microelements, fermented granulation of the soybean oil sediments, the peat soil and the like serve as organic matter and an anti-blushing agent, dryness and stabilization of fertilizer particles can be guaranteed to the maximum degree, the service life of the fertilizer is prolonged, and effectiveness of fertilizer nutrients is maintained.
Owner:ANHUI HUACHUANG MODERN AGRI TECH
Composite drug carried microsphere, minocycline hydrochloride nano controlled-release composite drug carried microsphere system and preparation method thereof
InactiveCN101836961BLow toxicityGood slow releaseAntibacterial agentsTetracycline active ingredientsMicrosphereCholesterol
Owner:TIANJIN UNIV
Mesoporous nano-zirconia drug-carrying material, preparation method thereof and controlled-release drug
ActiveCN109806400AAffects mesostructureImpact sizeNanomedicinePharmaceutical non-active ingredientsControl releaseMedicine
The invention relates to a mesoporous nano-zirconia drug-carrying material. The surface of mesoporous nano-zirconia is modified with an amino-containing group; the amino-containing group is selected from at least one of an aminosilane group, an amino-containing acrylic group and an amino-containing olefin group; the drug-carrying material has high drug carrying stability and biosecurity. The invention also relates to a preparation method of the mesoporous nano-zirconia drug-carrying material and application of the mesoporous nano-zirconia drug-carrying material in a controlled-release drug. The preparation method of the mesoporous nano-zirconia drug-carrying material is simple, efficient, and high in operability, and successively creates a mesoporous nano-zirconia drug-carrying system loading a negative charge drug active component, bringing a new method and a new idea for loading negative charge drugs which have different negative charges as the mesoporous nano-zirconia to the mesoporous nano-zirconia. The controlled release effect of the controlled-release drug is remarkable.
Owner:THE FIRST HOSPITAL OF CHINA MEDICIAL UNIV
Polyethylene glycol modified octreotide and preparation method thereof
InactiveCN110563809AGood slow and controlled release effectPeptide/protein ingredientsDigestive systemHalf-lifeTrifluoroacetic acid
The invention relates to the technical field of polypeptide drug preparation, and provides polyethylene glycol modified octreotide and a preparation method thereof. The method is characterized in thatthe method adopts a solid-phase synthesis method to couple octreotide main chains onto resin from a C end to an N end in sequence, an N end protecting group Fmoc is removed and then coupled with oneend of adipic acid through an amido bond, the other end of the adipic acid is coupled with polyethylene glycol, and finally, trifluoroacetic acid is used for deprotection and then liquid-phase cyclization is carried out. The compound can keep the original activity of the octreotide, overcomes the problem of short half-life period of the octreotide, greatly improves the clinical application compliance and has better application value.
Owner:应连心
Aqueous cellulose acetate (CA) dispersion and preparation method thereof
InactiveCN102108135AGood reproducibilityImprove stabilityPharmaceutical non-active ingredientsCellulose acetateMicroparticle
The invention relates to aqueous cellulose acetate (CA) dispersion and a preparation method thereof, and belongs to a preparation technology of a polymer micro-particle suspension. The preparation method is characterized in that CA is taken as a main raw material; an emulsifier, an organic solvent and water are taken as auxiliary materials; and the aqueous CA dispersion is prepared by utilizing an innovative method, namely an ethanol demulsification-centrifugal dispersion method. The invention aims at providing the brand-new aqueous CA dispersion and the preparation method thereof. The aqueous CA dispersion prepared by the method has the advantages of simplified processing technique, low requirements for preparation equipment, good repeatability and good stability, thus facilitating industrial production; meanwhile the aqueous CA dispersion also has the characteristics of higher solid content, low viscosity, less pollution, short coating time, good film forming property and good sustained and controlled release effect on medicaments; and the aqueous CA dispersion can be utilized as a taste masking material for masking unpleasant odor of the medicaments so as to increase the compliance of a patient.
Owner:COSCI MED TECH CO LTD
A kind of modified biological wax-coated controlled-release fertilizer and preparation method thereof
ActiveCN106380315BSimple production processLess investmentOrganic fertilisersFertilizer mixturesWaxSoil science
The invention discloses a modified bio-wax-coated controlled-release fertilizer and a preparation method thereof. The bio-wax is first melted and then modified by adding a modifier to change its melting point and toughness, and then coated as a coating material On the surface of the 2-5mm fertilizer particles, multiple coatings are carried out according to different melting points, and finally the coated controlled-release fertilizer is prepared after cooling; the weight of the coated material accounts for 1% to 10% of the total weight of the fertilizer. Compared with ordinary controlled-release fertilizers, the invention has the advantages of environmentally friendly and non-toxic membrane materials, simple production process, low investment, low energy consumption in the production process, and the like.
Owner:SHANDONG AGRI UNIV FERTILIZER TECH CO LTD
Fragrant health-care pillowcase
ActiveCN104127078AHas a long-lasting sustained-release effectStable blood concentrationPillowsPharmacyMaterials science
The invention relates to a fragrant health-care pillowcase. The fragrant health-care pillowcase comprises a pillowcase body and a binding tape, the binding tape and / or the pillowcase body constitutes at least one containing space, and the containing space is filled with substance from plants and with functions of incense and a mind tranquilizing function. According to the fragrant health-care pillowcase, a scientific process is adopted, one or more of lavender powder, lysimachia heterobotrys powder, jasmine flower powder and licorice powder are made into powder with a proper particle size or made into granules similar to granules in pharmacy, and accordingly the substance with mind relieving and tranquilizing functions has a long-acting slow-release effect.
Owner:汪建
Thermosensitive slow-release pharmaceutical composition of taxane drugs
ActiveCN104784109BEasy to makeHigh drug loadingOrganic active ingredientsAerosol deliveryControl releaseBeta-glycerophosphate
Owner:王子厚
An aromatic health pillowcase
ActiveCN104127078BHas a long-lasting sustained-release effectStable blood concentrationPillowsPharmacyMaterials science
The invention relates to a fragrant health-care pillowcase. The fragrant health-care pillowcase comprises a pillowcase body and a binding tape, the binding tape and / or the pillowcase body constitutes at least one containing space, and the containing space is filled with substance from plants and with functions of incense and a mind tranquilizing function. According to the fragrant health-care pillowcase, a scientific process is adopted, one or more of lavender powder, lysimachia heterobotrys powder, jasmine flower powder and licorice powder are made into powder with a proper particle size or made into granules similar to granules in pharmacy, and accordingly the substance with mind relieving and tranquilizing functions has a long-acting slow-release effect.
Owner:汪建
Preparation method of urea formaldehyde and polyolefin coating material of fertilizers
InactiveCN106518345AGood slow and controlled release effectWide variety of sourcesLayered/coated fertilisersFertilizer mixturesFertilizerPolyolefin
The invention belongs to the technical fields of materials and fertilizers, and particularly relates to a preparation method of a urea formaldehyde and polyolefin coating material of fertilizers. The coating material comprises the following raw materials in parts by weight: 70 to 80 parts of urea formaldehyde, 10 to 20 parts of polyolefin and 1 to 5 parts of a cross-linking agent. The preparation method comprises the steps of putting urea formaldehyde and polyolefin into a reaction kiln in parts by weight, adding water, carrying out uniform stirring and mixing, heating the mixture to 70 DEG C to 80 DEG C, carrying out gelatinization, adding the cross-linking agent in parts by weight, and carrying out reflux at the temperature of 90 DEG C to 100 DEG C to enable the materials to perform cross-linking reaction; and then, carrying out stirring and cooling discharge, so as to obtain a dispersion liquid of the urea formaldehyde and polyolefin coating material in water. Slow and controlled release fertilizers of different release periods can be prepared through adjustment of component composition of the coating material and ratio of the coating material to fertilizer particles. According to the prepared slow and controlled release fertilizers, the utilized raw materials are wide in source, cheap, and easy to obtain, the preparation method is simple, the slow and controlled release effect is excellent, and industrial production is facilitated.
Owner:王兵
Nanopesticides for controlling Monochamus alternata and pine xylophilus
ActiveCN110786334BUniform and stable particle sizeGood dispersionBiocideNematocidesAbamectinCell wall
The invention discloses a novel nano pesticide for preventing and treating monochamus alternatus and pine wood nematodes. The novel nano pesticide is a nano pesticide preparation prepared by taking nano Cu-BTC as a carrier to load pesticide abamectin; the nano Cu-BTC serving as the carrier is uniform and stable in particle size and good in dispersity, and agglomeration is avoided; the interior ofthe nano Cu-BTC is of a porous structure, so that the nano Cu-BTC has a relatively large specific surface area, high drug loading capacity and a quite good sustained and controlled release effect. Theprepared nano pesticide preparation can penetrate through cell wall barriers of plants due to the nano size, and the pesticide is transported into barks and is used for preventing and treating monochamus alternatus and pine wood nematodes.
Owner:SHANDONG AGRICULTURAL UNIVERSITY
Mesoporous nano zirconia drug-loaded material, its preparation method and sustained and controlled drug release
ActiveCN109806400BGood drug loading stabilityHigh biosecurityNanomedicinePharmaceutical non-active ingredientsControlled drugsControl release
The invention relates to a drug-loaded material of mesoporous nano zirconia. The surface of the mesoporous nano zirconia is modified with groups with amino groups; group, at least one of an amino-containing alkene group. The drug-loading material has good drug-loading stability and high biological safety. The invention also relates to a preparation method of the mesoporous nanometer zirconium dioxide drug-loading material and its application in slow and controlled drug release. The preparation method of the mesoporous nano-zirconia drug-loading material is simple, efficient, and highly operable. It has successfully constructed a mesoporous nano-zirconia drug-loaded system loaded with negatively charged drug active components, which is a mesoporous nano-zirconia drug-loaded system. Negatively charged drugs with zirconium loading and their own charges bring a new method and idea, and the sustained and controlled release effect of the drug is remarkable.
Owner:THE FIRST HOSPITAL OF CHINA MEDICIAL UNIV
A kind of ordered nanofiber loaded with antitumor drug and its preparation method
ActiveCN105543998BLarge specific surface areaHigh porosityOrganic active ingredientsMonocomponent protein artificial filamentFiberControlled release
Owner:HUAQIAO UNIVERSITY
Fragrant health care summer sleeping mat
ActiveCN104146544BHas a long-lasting sustained-release effectStable blood concentrationBed-coversEngineeringPlant matter
The invention relates to a fragrant health care summer sleeping mat. The fragrant health care summer sleeping mat comprises a summer sleeping mat body and covered edges. At least two layers of covered edges are arranged to form at least one accommodating space. The accommodating space is filled with incense and / or plant matter with a tranquilizing effect. According to the fragrant health care summer sleeping mat, one or more kinds among lavender powder, lysimachia heterobotrys powder, jasmine flower powder and licorice powder are made into powder with an appropriate particle size or similar medical granules through scientific processes, so that the matter with the tranquilizing effect has a long-acting slow-release effect.
Owner:汪建
Root-friendly magnetic slow release fertilizer and preparation method therefor
InactiveCN105016862APromote photosynthesisPromote growth and developmentBio-organic fraction processingOrganic fertiliser preparationAbsorption capacityCoal
The present invention discloses a root-friendly magnetic slow release fertilizer and a preparation method therefor. The root-friendly magnetic slow release fertilizer is made of the following raw materials in parts by weight: 80-90 parts of bone powder, 12-15 parts of calcium nitrate, 150-160 parts of vermicompost, 120-140 parts of tobacco dust, 18-20 parts of carnallite powder, 25-30 parts of carbamide, 75-95 parts of coal ash, 50-60 parts of pyrite ash, 18-22 parts of tapioca starch, 5-7 parts of calcium acetate, 16-18 parts of a composite biological agent and an appropriate amount of water. According to the invention, the fertilizer is prepared from a main raw material of an organic matter. After the organic matter is applied into soil, the constitution of the soil environment of crop roots can be optimized. Adding various beneficial strain species has a protective effect on the root, and prevents the root from destruction of pathogenic inoculation. As absorbable components, carnallite powder and carbamide can promote growth of the crop roots and induce the roots to extend into deep soil, thereby improving crop nutrition absorption capacity and production performance.
Owner:ANHUI HUIHUANG FERTILIZER IND CO LTD
Sustained and controlled release preparation and preparation method and preparation of in situ tumor immune combination therapy drug application
ActiveCN111888475BEffective regulationGrowth inhibitionOrganic active ingredientsDrug photocleavageImmunomodulating AgentImmunogenicity
The invention discloses a sustained and controlled release preparation, a preparation method and the application of preparing in situ tumor immunotherapy combined therapy, and relates to the technical field of biomedical nanomaterials. The sustained and controlled release preparation uses a liquid crystal gel as a carrier, and the liquid crystal gel is loaded with an immunogenic inducer and an immunomodulator. The sustained and controlled release preparation can be prepared into a liquid crystal precursor by a simple stirring and mixing method, and then loaded with an immunogenic inducer and an immunomodulator. In the present invention, the immunogenic inducer and the immunomodulator are co-loaded in the in-situ slow-release liquid crystal gel, and after intratumoral, peritumoral or postoperative intratumoral administration, a semi-solid gel can be formed in situ, and the sustained-control Release drugs, effectively regulate the tumor microenvironment, play a role in inhibiting tumor growth, recurrence and metastasis, while reducing systemic side effects caused by traditional drug administration routes, and have potential application prospects in in situ local treatment of tumors.
Owner:HUAZHONG UNIV OF SCI & TECH
A Method for Preparation of Thymopentin Molecularly Imprinted Hydrogels by Wave Polymerization
Owner:TIANJIN MEDICAL UNIV
A kind of injection preparation containing exendin-4 Fc fusion protein
ActiveCN109394681BStable qualityHigh purityPeptide/protein ingredientsMetabolism disorderActive agentBiophysics
The invention relates to the field of biological medicines, and particularly provides an injection preparation containing Exendin-4Fc fusion protein. The injection preparation is prepared from the Exendin-4Fc fusion protein and injection mixed liquid, wherein a pH value of the injection mixed liquid is 6.0-6.7, each millilitre of the injection preparation contains 1.5-2.5 mg of the Exendin-4Fc fusion protein, and the injection mixed liquid is prepared from the following components in parts by weight: 0.1-2.0 parts of surfactant, 0.1-0.8 part of a solution buffering agent, 5-10 parts of an osmotic pressure adjusting agent and 50-90 parts of stabilizer. The injection preparation containing the Exendin-4Fc fusion protein can be stably stored for at least 36 months under circumstances in whichvarious detection indexes are stable, and corresponding physicochemical quality standards are met, so that a storage life of the Exendin-4Fc fusion protein is effectively prolonged.
Owner:BEIJING DONGFANG BIOTECH
Calcium alginate-chitosan microspheres and preparation method thereof, drug-loaded calcium alginate-chitosan and preparation method thereof
ActiveCN109464423BSimple processEasy to operateAntibacterial agentsOrganic active ingredientsControl releaseDrug carrier
The present invention provides a kind of calcium alginate-chitosan microsphere and its preparation method, drug-loaded calcium alginate-chitosan and its preparation method, relate to the technical field of drug carrier, the calcium alginate-chitosan microsphere The preparation method comprises the steps of: spraying the sodium alginate solution into the mixed solution of chitosan and calcium chloride by electrostatic spraying to obtain calcium alginate-chitosan microspheres, and improving the microspheres prepared by the precipitation method and the emulsification method The technical problem of the slow and controlled release performance of the drug carrier is not good. The calcium alginate-chitosan microspheres provided by the present invention are prepared by electrostatic spraying. The process is simple, the operation is convenient, and the particle size of the microspheres is uniform. 20‑50μm, making it easier to precisely control the slow and controlled release of the drug after it is loaded with the drug.
Owner:WUYI UNIV
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