40results about How to "Good slow and controlled release effect" patented technology

The invention relates to a composite drug carried microsphere, a minocycline hydrochloride nano controlled-release composite drug carried microsphere system and a preparation method thereof. A drug carried system with a nuclear shell structure is formed by embedding minocycline hydrochloride inside a poly D,L-lactide-co-glycolic acid polymer microsphere and covering a cationic polymeric liposome prepared from O-QACMC modified by polyethylene glycol, O-QACMC and cholesterol outside the poly D, L-lactide-co-glycolic acid polymer microsphere; and the composite drug carried microsphere system covered and carried with the minocycline hydrochloride has the grain diameter ranging from 340 nm to 400 nm and positive surface Zeta electric potential. The composite drug carried microsphere system can be remained in a water solution for at least 2 months, has high entrapment rate reaching larger than 90 percent on drugs and strong drug carrying capacity reaching 9 percent. The minocycline hydrochloride nano controlled-release composite drug carried microsphere system has the characteristics of uniform and controllable grain diameter, good preparation stability, simple preparation process, high drug carrying rate, favorable controlled release function, and the like, and is suitable for batch production.

The invention discloses a modified biological wax coated controlled-release fertilizer and a preparation method thereof; the preparation method comprises the steps: firstly, melting biological wax, then adding a modifier, and modifying to change the melting point and toughness; then taking the modified biological wax as a coating material to coat the surface of 2-5 mm fertilizer particles, and coating for a plurality of times according to different melting points; and finally, cooling to prepare the coated controlled-release fertilizer, wherein the weight of the coating material accounts for 1%-10% of the total weight of the fertilizer. Compared with ordinary controlled-release fertilizer, the modified biological wax coated controlled-release fertilizer has the advantages of environmental-protection and no-toxic film material, simple production process, low investment, low energy consumption in the production process and the like.

The invention discloses a hydrophobic pesticide preparation containing microcapsules and a preparation method of the hydrophobic pesticide preparation containing the microcapsules. The type of the preparation is water emulsion and microcapsule suspending agent; the microcapsules contain core materials and wall materials; the core materials are active ingredients encapsulated in the microcapsules and are alternatively selected from the following substances: chlorpyrifos, malathion, pyraclostrobin and acetochlor, wherein the drug loading capacity is 10 to 30 percent counted by mass; the wall materials are biodegradable polymer materials and are alternatively selected from the following substances: polycaprolactone (PCL), poly lactide-glycolic acid (PLGA) copolymer and polylactic acid (PVA); active ingredients of the water emulsion are core materials which are not encapsulated in the microcapsules. According to the hydrophobic pesticide preparation disclosed by the invention, by adopting biodegradable environment-friendly polymer as the wall materials, hydrophobic pesticide is effectively coated, a significant sustained-release effect is realized, the utilization rate of pesticide is improved, the acting time of the pesticide is prolonged, the production cost is reduced, and the aims of reducing pesticide applying times and the pressure of a biological environment are achieved.

The invention discloses a dampproof easily-absorbed magnetized slow-release fertilizer and a preparation method thereof. The dampproof easily-absorbed magnetized slow-release fertilizer is prepared from, by weight, 45-65 parts of soybean oil sediments, 35-40 parts of peat soil, 160-190 parts of sesame meal, 10-12 parts of magnesium nitrate, 26-28 parts of potassium hydrogen phosphate, 250-280 parts of Chinese medicine residues, 23-25 parts of EDTA chelate boron, 80-100 parts of flyash, 55-60 parts of iron pyrite ash, 30-35 parts of cassava starch, 5-8 parts of lime acetate, 20-24 parts of a composite bacterial strain and a proper amount of water. According to the fertilizer, raw materials contain sufficient nitrogen, phosphorus and potassium which are greatly needed by plants, meanwhile the EDTA chelate boron and chelating liquid of a coated layer are utilized, it is beneficial for the plants to absorb various microelements, fermented granulation of the soybean oil sediments, the peat soil and the like serve as organic matter and an anti-blushing agent, dryness and stabilization of fertilizer particles can be guaranteed to the maximum degree, the service life of the fertilizer is prolonged, and effectiveness of fertilizer nutrients is maintained.

The invention relates to a composite drug carried microsphere, a minocycline hydrochloride nano controlled-release composite drug carried microsphere system and a preparation method thereof. A drug carried system with a nuclear shell structure is formed by embedding minocycline hydrochloride inside a poly D,L-lactide-co-glycolic acid polymer microsphere and covering a cationic polymeric liposome prepared from O-QACMC modified by polyethylene glycol, O-QACMC and cholesterol outside the poly D, L-lactide-co-glycolic acid polymer microsphere; and the composite drug carried microsphere system covered and carried with the minocycline hydrochloride has the grain diameter ranging from 340 nm to 400 nm and positive surface Zeta electric potential. The composite drug carried microsphere system canbe remained in a water solution for at least 2 months, has high entrapment rate reaching larger than 90 percent on drugs and strong drug carrying capacity reaching 9 percent. The minocycline hydrochloride nano controlled-release composite drug carried microsphere system has the characteristics of uniform and controllable grain diameter, good preparation stability, simple preparation process, highdrug carrying rate, favorable controlled release function, and the like, and is suitable for batch production.

The invention relates to the technical field of polypeptide drug preparation, and provides polyethylene glycol modified octreotide and a preparation method thereof. The method is characterized in thatthe method adopts a solid-phase synthesis method to couple octreotide main chains onto resin from a C end to an N end in sequence, an N end protecting group Fmoc is removed and then coupled with oneend of adipic acid through an amido bond, the other end of the adipic acid is coupled with polyethylene glycol, and finally, trifluoroacetic acid is used for deprotection and then liquid-phase cyclization is carried out. The compound can keep the original activity of the octreotide, overcomes the problem of short half-life period of the octreotide, greatly improves the clinical application compliance and has better application value.

The invention discloses a modified bio-wax-coated controlled-release fertilizer and a preparation method thereof. The bio-wax is first melted and then modified by adding a modifier to change its melting point and toughness, and then coated as a coating material On the surface of the 2-5mm fertilizer particles, multiple coatings are carried out according to different melting points, and finally the coated controlled-release fertilizer is prepared after cooling; the weight of the coated material accounts for 1% to 10% of the total weight of the fertilizer. Compared with ordinary controlled-release fertilizers, the invention has the advantages of environmentally friendly and non-toxic membrane materials, simple production process, low investment, low energy consumption in the production process, and the like.

The invention relates to a temperature-sensitive controlled-release pharmaceutical composition of taxane drugs. Specifically speaking, the invention relates to the pharmaceutical composition which comprises taxane drugs, chitosan, sodium beta-glycerophosphate, ethanol and water, and further relates to a preparation method for the pharmaceutical composition. The pharmaceutical composition can be used for preparation of anticancer drugs. In particular, the anticancer drugs are applied to treatment of malignant tumors or prevention of recurrence after operation through a stereotaxical injection approach and can be cooperatively used with radiotherapy and traditional Chinese medicine.

The invention relates to a fragrant health-care pillowcase. The fragrant health-care pillowcase comprises a pillowcase body and a binding tape, the binding tape and / or the pillowcase body constitutes at least one containing space, and the containing space is filled with substance from plants and with functions of incense and a mind tranquilizing function. According to the fragrant health-care pillowcase, a scientific process is adopted, one or more of lavender powder, lysimachia heterobotrys powder, jasmine flower powder and licorice powder are made into powder with a proper particle size or made into granules similar to granules in pharmacy, and accordingly the substance with mind relieving and tranquilizing functions has a long-acting slow-release effect.

The invention discloses a novel nano pesticide for preventing and treating monochamus alternatus and pine wood nematodes. The novel nano pesticide is a nano pesticide preparation prepared by taking nano Cu-BTC as a carrier to load pesticide abamectin; the nano Cu-BTC serving as the carrier is uniform and stable in particle size and good in dispersity, and agglomeration is avoided; the interior ofthe nano Cu-BTC is of a porous structure, so that the nano Cu-BTC has a relatively large specific surface area, high drug loading capacity and a quite good sustained and controlled release effect. Theprepared nano pesticide preparation can penetrate through cell wall barriers of plants due to the nano size, and the pesticide is transported into barks and is used for preventing and treating monochamus alternatus and pine wood nematodes.

The invention relates to a drug-loaded material of mesoporous nano zirconia. The surface of the mesoporous nano zirconia is modified with groups with amino groups; group, at least one of an amino-containing alkene group. The drug-loading material has good drug-loading stability and high biological safety. The invention also relates to a preparation method of the mesoporous nanometer zirconium dioxide drug-loading material and its application in slow and controlled drug release. The preparation method of the mesoporous nano-zirconia drug-loading material is simple, efficient, and highly operable. It has successfully constructed a mesoporous nano-zirconia drug-loaded system loaded with negatively charged drug active components, which is a mesoporous nano-zirconia drug-loaded system. Negatively charged drugs with zirconium loading and their own charges bring a new method and idea, and the sustained and controlled release effect of the drug is remarkable.

The invention discloses an ordered nano-fiber loaded with an anti-tumor medicine and a preparation method thereof. According to the invention, preparation of the ordered nano-fiber is realized; the obtained nano-fiber has a small diameter and good mechanical properties; the medicine loaded on the ordered nano-fiber has a uniformly distributed concentration; good sustained-and-controlled release effect is achieved; and the preparation method is simple, fast, low in cost, green, environment-friendly, good in reproducibility and suitable for industrial production.

The invention relates to a fragrant health care summer sleeping mat. The fragrant health care summer sleeping mat comprises a summer sleeping mat body and covered edges. At least two layers of covered edges are arranged to form at least one accommodating space. The accommodating space is filled with incense and / or plant matter with a tranquilizing effect. According to the fragrant health care summer sleeping mat, one or more kinds among lavender powder, lysimachia heterobotrys powder, jasmine flower powder and licorice powder are made into powder with an appropriate particle size or similar medical granules through scientific processes, so that the matter with the tranquilizing effect has a long-acting slow-release effect.

The invention discloses a sustained and controlled release preparation, a preparation method and the application of preparing in situ tumor immunotherapy combined therapy, and relates to the technical field of biomedical nanomaterials. The sustained and controlled release preparation uses a liquid crystal gel as a carrier, and the liquid crystal gel is loaded with an immunogenic inducer and an immunomodulator. The sustained and controlled release preparation can be prepared into a liquid crystal precursor by a simple stirring and mixing method, and then loaded with an immunogenic inducer and an immunomodulator. In the present invention, the immunogenic inducer and the immunomodulator are co-loaded in the in-situ slow-release liquid crystal gel, and after intratumoral, peritumoral or postoperative intratumoral administration, a semi-solid gel can be formed in situ, and the sustained-control Release drugs, effectively regulate the tumor microenvironment, play a role in inhibiting tumor growth, recurrence and metastasis, while reducing systemic side effects caused by traditional drug administration routes, and have potential application prospects in in situ local treatment of tumors.

The invention relates to a frontal polymerization preparation method for a thymopentin molecular imprinted hydrogel which is prepared from the raw materials in percentage by mass: 4.33%-11.94% of thymopentin, 10.00%-36.44% of N-isopropylacrylamide, 5.88%-21.86% of acrylic acid, 0.36%-0.74% of N, N'-methylenebisacrylamide, 9.92%-33.58% of choline chloride and 30.12%-53.68% of ethylene glycol. By using the frontal polymerization preparation method, a molecular imprinted hydrogel sustained-release material is prepared by taking bioactive molecule thymopentin as a template and a green solvent DESsystem as a pore-foaming agent, and the molecular imprinted hydrogel sustained-release material serving as a drug carrier is stable in physical and chemical properties and obvious in imprinting effect; the molecular imprinted hydrogel sustained-release material is large in drug loading capacity and has an obvious sustained-release effect for the template molecule thymopentin; and compared with a thermal polymerization imprinted hydrogel, the molecular imprinted hydrogel sustained-release material is capable of prolonging the in-vivo metabolism time of a drug and increasing the biological availability of the drug.

The present invention provides a kind of calcium alginate-chitosan microsphere and its preparation method, drug-loaded calcium alginate-chitosan and its preparation method, relate to the technical field of drug carrier, the calcium alginate-chitosan microsphere The preparation method comprises the steps of: spraying the sodium alginate solution into the mixed solution of chitosan and calcium chloride by electrostatic spraying to obtain calcium alginate-chitosan microspheres, and improving the microspheres prepared by the precipitation method and the emulsification method The technical problem of the slow and controlled release performance of the drug carrier is not good. The calcium alginate-chitosan microspheres provided by the present invention are prepared by electrostatic spraying. The process is simple, the operation is convenient, and the particle size of the microspheres is uniform. 20‑50μm, making it easier to precisely control the slow and controlled release of the drug after it is loaded with the drug.