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Aqueous cellulose acetate (CA) dispersion and preparation method thereof

A technology of cellulose acetate and dispersion, which is applied in the field of polymer microparticle suspension preparation, and can solve the problems of not finding cellulose acetate aqueous dispersion and not obtaining finished products, etc.

Inactive Publication Date: 2011-06-29
COSCI MED TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are few reports on the preparation method of the cellulose acetate aqueous dispersion in the world, and the emulsification-solvent evaporation method is commonly used, but there is no market report about the cellulose acetate aqueous dispersion in the current market. At the same time, repeated emulsification-solvent evaporation method to prepare cellulose acetate aqueous dispersion did not get the ideal finished product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (A) With ethyl acetate: ethanol = 95: 5 mixture as the organic phase, cellulose acetate (U.S. Eastman Chemical Company) accounting for 10 parts of the oil phase and 2 parts of cetyl alcohol accounting for the oil phase were added to the organic phase , dissolved in an oily phase.

[0025] (B) Sodium lauryl sulfate accounting for 1 part of the water phase was dissolved in distilled water to prepare the water phase.

[0026] (C) At the speed of the disperser at 13500 (rev / min), add the water phase obtained in (B) to the oil phase obtained in (A) to prepare a W / O emulsion, and continue to add the water phase until phase inversion to obtain O After the / W type emulsion, stop the dispersion and place it at 25°C.

[0027] (D) Add distilled water to the O / W type emulsion obtained in (C) to dilute it by 1 time, slowly add the diluted emulsion to 85 parts of ethanol of the diluted emulsion, and break the emulsion to obtain an emulsion suspension.

[0028] (E) Pass the demulsif...

Embodiment 2

[0031] (A) Take ethyl acetate: ethanol = 95: 5 mixture as the organic phase, add cellulose acetate accounting for 10 parts of the oil phase and 2 parts of cetyl alcohol accounting for the oil phase into the organic phase respectively, and dissolve to obtain the oil phase .

[0032] (B) Sodium lauryl sulfate accounting for 0.5 parts of the water phase was dissolved in distilled water to prepare a water phase.

[0033] (C) At the speed of the disperser at 17500 (rev / min), add the water phase obtained in (B) to the oil phase obtained in (A) to obtain a W / O emulsion, and continue to add the water phase until phase inversion to obtain After the O / W emulsion, stop the dispersion and place it at 30°C.

[0034] (D) Add distilled water to the O / W type emulsion obtained in (C) to dilute by 1.5 times, slowly add the diluted emulsion to 70 parts of ethanol of the diluted emulsion, and break the emulsion to obtain an emulsion suspension.

[0035] (E) Pass the demulsified suspension obtai...

Embodiment 3

[0038] (A) Take ethyl acetate: ethanol = 75: 25 mixture as the organic phase, add cellulose acetate accounting for 18 parts of the oil phase and 12 parts of cetyl alcohol accounting for the oil phase into the organic phase respectively, and dissolve to obtain the oil phase .

[0039] (B) Sodium lauryl sulfate accounting for 4 parts of the water phase was dissolved in distilled water to prepare the water phase.

[0040] (C) With the speed of the disperser at 20000 (rev / min), add the water phase obtained in (B) to the oil phase obtained in (A) to obtain a W / O emulsion, and continue to add the water phase until phase inversion to obtain After the O / W emulsion, stop the dispersion and place it at 40°C.

[0041](D) Add distilled water to the O / W type emulsion obtained in (C) to dilute 4 times, slowly add the diluted emulsion to 180 parts of ethanol of the diluted emulsion, and break the emulsion to obtain an emulsion suspension.

[0042] (E) Pass the demulsified suspension obtain...

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PUM

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Abstract

The invention relates to aqueous cellulose acetate (CA) dispersion and a preparation method thereof, and belongs to a preparation technology of a polymer micro-particle suspension. The preparation method is characterized in that CA is taken as a main raw material; an emulsifier, an organic solvent and water are taken as auxiliary materials; and the aqueous CA dispersion is prepared by utilizing an innovative method, namely an ethanol demulsification-centrifugal dispersion method. The invention aims at providing the brand-new aqueous CA dispersion and the preparation method thereof. The aqueous CA dispersion prepared by the method has the advantages of simplified processing technique, low requirements for preparation equipment, good repeatability and good stability, thus facilitating industrial production; meanwhile the aqueous CA dispersion also has the characteristics of higher solid content, low viscosity, less pollution, short coating time, good film forming property and good sustained and controlled release effect on medicaments; and the aqueous CA dispersion can be utilized as a taste masking material for masking unpleasant odor of the medicaments so as to increase the compliance of a patient.

Description

technical field [0001] The invention relates to a cellulose acetate aqueous dispersion and a preparation method thereof, belonging to the preparation technology of polymer particle suspension. Background technique [0002] Cellulose acetate (CA) is a thermoplastic, water-insoluble, non-ionic cellulose acetylate, which has the characteristics of chemical resistance, salt resistance, acid resistance and thermal stability, can be dissolved in various organic solvents, and is easy to Compatible with waxes, resins, plasticizers, etc., so it has been more and more widely used in the field of medicine, especially in the field of sustained and controlled release film coating technology. Cellulose acetate is the most widely used water-insoluble polymer in controlled-release film coatings. It has good coating properties and can produce coatings with good toughness and resistance to abrasion. So far, there are few reports on the preparation method of the cellulose acetate aqueous disp...

Claims

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Application Information

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IPC IPC(8): C08L1/12C08J3/05A61K47/38
Inventor 蒋海松王锦刚杨大伟
Owner COSCI MED TECH CO LTD
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