A kind of ordered nanofiber loaded with antitumor drug and its preparation method

An anti-tumor drug and nanofiber technology, applied in anti-tumor drugs, drug combination, fiber treatment and other directions, can solve the problems of uneven local drug distribution, drug burst release phenomenon, slow-release effect and other problems, and achieve drug-loaded concentration distribution. Uniform, good slow and controlled release effect, solving the effect of large local differences

Active Publication Date: 2018-02-23
HUAQIAO UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing problems cannot be ignored. The disordered arrangement may lead to uneven distribution of local drugs, and it is very likely that the drug will be released suddenly.

Method used

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  • A kind of ordered nanofiber loaded with antitumor drug and its preparation method
  • A kind of ordered nanofiber loaded with antitumor drug and its preparation method
  • A kind of ordered nanofiber loaded with antitumor drug and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 1) In terms of parts by mass, 8 parts of dichloromethane and 2 parts of dimethylformamide are mixed to prepare a mixed solvent; the molecular weight is 8×10 4 Da polycaprolactone (PCL) and antineoplastic drug paclitaxel (purity ≥ 95%) are dissolved in this mixed solvent, wherein the amount of paclitaxel accounts for 1% of the total mass of paclitaxel and polycaprolactone, and polycaprolactone after dissolving The final concentration of lactone is 10%; stirring at 25°C for 12 hours, standing for degassing for 2 hours, to obtain an electrospinning solution;

[0034] 2) Put the electrospinning solution in step 1) into a syringe at 25-35°C and a relative humidity of 40-70%, and perform electrospinning with a spinning voltage of 8kV and a spinning flow rate of 600μL / h; the receiver It is a parallel plate receiver arranged in parallel and spaced up and down, and the distance between the two plates is 10cm; the horizontal distance between the syringe needle, that is, the spinn...

Embodiment 2

[0037] 1) In terms of parts by mass, 8 parts of dichloromethane and 2 parts of dimethylformamide are mixed to prepare a mixed solvent; the molecular weight is 8×10 4 Da polycaprolactone and antineoplastic drug paclitaxel (purity ≥ 95%) are dissolved in this mixed solvent, wherein the amount of paclitaxel accounts for 2% of the total mass of paclitaxel and polycaprolactone, and the polycaprolactone after dissolving The final concentration is 10%, stirring at 25°C for 12 hours, standing for degassing for 2 hours, to obtain an electrospinning solution;

[0038] 2) Put the electrospinning solution in step 1) into a syringe at 25-35°C and a relative humidity of 40-70%, and perform electrospinning with a spinning voltage of 8kV and a spinning flow rate of 600μL / h; the receiver It is a parallel plate receiver arranged in parallel and spaced up and down, and the distance between the two plates is 10cm; the horizontal distance between the syringe needle, that is, the spinneret and the ...

Embodiment 3

[0041] 1) In terms of parts by mass, 8 parts of dichloromethane and 2 parts of dimethylformamide are mixed to prepare a mixed solvent; the molecular weight is 8×10 4 Da polycaprolactone and antineoplastic drug paclitaxel (purity ≥ 95%) are dissolved in this mixed solvent, wherein the amount of paclitaxel accounts for 3% of the total mass of paclitaxel and polycaprolactone, and the polycaprolactone after dissolving The final concentration is 10%, stirring at 25°C for 12 hours, standing for degassing for 2 hours, to obtain an electrospinning solution;

[0042]2) Put the electrospinning solution in step 1) into a syringe at 25-35°C and a relative humidity of 40-70%, and perform electrospinning with a spinning voltage of 8kV and a spinning flow rate of 600μL / h; the receiver It is a parallel plate receiver arranged in parallel and spaced up and down, and the distance between the two plates is 10cm; the horizontal distance between the syringe needle, that is, the spinneret and the r...

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Abstract

The invention discloses an ordered nano-fiber loaded with an anti-tumor medicine and a preparation method thereof. According to the invention, preparation of the ordered nano-fiber is realized; the obtained nano-fiber has a small diameter and good mechanical properties; the medicine loaded on the ordered nano-fiber has a uniformly distributed concentration; good sustained-and-controlled release effect is achieved; and the preparation method is simple, fast, low in cost, green, environment-friendly, good in reproducibility and suitable for industrial production.

Description

technical field [0001] The invention relates to an ordered nanofiber loaded with antitumor drugs and a preparation method thereof. Background technique [0002] With the continuous development of nanotechnology, nanofibers prepared by electrospinning technology have been widely studied and applied in the field of biomedicine. Nanofibers prepared by electrospinning have structural characteristics such as large specific surface area, high porosity and good tensile properties. The polymer material is degradable and the prepared nanofiber has a high porosity. The drug-loaded nanofiber membrane can be released slowly in the body. The release time of the drug in the body can be controlled according to the degradation rate of the polymer to achieve a sustained release effect, and there is no drug in the body. burst phenomenon. Electrospun nanofiber drug loading provides a new idea for the development of sustained-release preparations, and is expected to be widely used in the fiel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D01F6/92D01F4/00D01F1/10D01D5/00D04H1/435D04H1/4266D04H1/728A61K47/34A61K45/00A61P35/00A61K31/337A61L27/18A61L27/22A61L27/54
CPCA61K31/337A61K45/00A61K47/34A61L27/18A61L27/222A61L27/227A61L27/54A61L2300/416D01D5/003D01D5/0076D01D5/0092D01F1/10D01F4/00D01F6/92D04H1/4266D04H1/435D04H1/728C08L67/04
Inventor 汤须崇寇馨月雷廷平肖尚晨徐祥赵雯
Owner HUAQIAO UNIVERSITY
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