Mesoporous nano-zirconia drug-carrying material, preparation method thereof and controlled-release drug

A technology of nano-zirconia and controlled-release drugs, which is applied in the field of mesoporous nano-zirconia drug-loaded materials, its preparation, and sustained-release drugs

Active Publication Date: 2019-05-28
THE FIRST HOSPITAL OF CHINA MEDICIAL UNIV
View PDF6 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for drugs with negative charges on the surface, drug loading cannot be carried out by conventional vacuum pumping negative pressure.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Mesoporous nano-zirconia drug-carrying material, preparation method thereof and controlled-release drug
  • Mesoporous nano-zirconia drug-carrying material, preparation method thereof and controlled-release drug
  • Mesoporous nano-zirconia drug-carrying material, preparation method thereof and controlled-release drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] Take 20mg of mesoporous nano-zirconia particles, add 5mL of deionized water and 5mL of absolute ethanol, mix thoroughly, then quickly add 40μL of aminosilane dropwise under magnetic stirring conditions, and magnetically stir overnight;

[0082] Put the mesoporous nano-zirconia particles stirred overnight into a centrifuge tube, centrifuge at a high speed (10000r / min, 10min), discard the supernatant, wash twice with 5mL of absolute ethanol and twice with 5mL of deionized water, and discard Remove the supernatant to obtain the aminated mesoporous nano-zirconia drug-loaded material;

[0083] Take 40mg of arsenic trioxide powder, mix thoroughly with 20mL of deionized water, stir overnight by magnetic force, fully dissolve the drug, and obtain arsenic trioxide solution;

[0084] Mix the above-mentioned arsenic trioxide solution into the above-mentioned aminated mesoporous nano-zirconia particles, under the condition of ultrasonic vibration (ultrasonic power is 50W, ultrasoni...

Embodiment 2

[0087] Take 20mg of mesoporous nano-zirconia particles, add 5mL of deionized water and 5mL of absolute ethanol, mix thoroughly, then quickly add 40μL of aminosilane dropwise under magnetic stirring conditions, and magnetically stir overnight;

[0088] Put the mesoporous nano-zirconia particles stirred overnight into a centrifuge tube, centrifuge at a high speed (10000r / min, 10min), discard the supernatant, wash twice with 5mL of absolute ethanol and twice with 5mL of deionized water, and discard Remove the supernatant to obtain the aminated mesoporous nano-zirconia drug-loaded material;

[0089] Take 40mg of arsenic trioxide powder, mix thoroughly with 20mL of deionized water, stir overnight by magnetic force, fully dissolve the drug, and obtain arsenic trioxide solution;

[0090] Mix the above-mentioned arsenic trioxide solution into the above-mentioned aminated mesoporous nano-zirconia particles, under the condition of ultrasonic vibration (ultrasonic power is 60W, ultrasoni...

Embodiment 3～5

[0093] The method in Examples 3-5 refers to the method in Example 1, the difference is that the amount or type of each substance, centrifugation or ultrasonic conditions, etc. are changed, and the specific condition changes are listed in Table 1.

[0094] Table 1 embodiment 3~5 concrete condition changes

[0095]

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a mesoporous nano-zirconia drug-carrying material. The surface of mesoporous nano-zirconia is modified with an amino-containing group; the amino-containing group is selected from at least one of an aminosilane group, an amino-containing acrylic group and an amino-containing olefin group; the drug-carrying material has high drug carrying stability and biosecurity. The invention also relates to a preparation method of the mesoporous nano-zirconia drug-carrying material and application of the mesoporous nano-zirconia drug-carrying material in a controlled-release drug. The preparation method of the mesoporous nano-zirconia drug-carrying material is simple, efficient, and high in operability, and successively creates a mesoporous nano-zirconia drug-carrying system loading a negative charge drug active component, bringing a new method and a new idea for loading negative charge drugs which have different negative charges as the mesoporous nano-zirconia to the mesoporous nano-zirconia. The controlled release effect of the controlled-release drug is remarkable.

Description

technical field [0001] The invention relates to the fields of pharmaceutical preparations and drug loading, in particular to a mesoporous nano-zirconia drug-loading material, a preparation method thereof, and sustained-controlled drug release. Background technique [0002] At present, the drug commonly used to load mesoporous zirconia nanoparticles is doxorubicin hydrochloride. Since the charge attached to the surface of doxorubicin hydrochloride is positive, the negatively charged nano-zirconia particles on the surface can attract and mediate. The role of the pore structure, the use of vacuum negative pressure to achieve the effect of drug loading. However, for drugs with negative charges on the surface, drug loading cannot be carried out by conventional vacuum pumping. Therefore, it is of great practical significance to develop suitable mesoporous nano-zirconia particle drug-loading materials and preparation methods for loading negatively charged drugs. [0003] In view ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61K47/52B82Y5/00
Inventor 吴启润徐克
Owner THE FIRST HOSPITAL OF CHINA MEDICIAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap