Mesoporous nano-zirconia drug-carrying material, preparation method thereof and controlled-release drug
A technology of nano-zirconia and controlled-release drugs, which is applied in the field of mesoporous nano-zirconia drug-loaded materials, its preparation, and sustained-release drugs
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Embodiment 1
[0081] Take 20mg of mesoporous nano-zirconia particles, add 5mL of deionized water and 5mL of absolute ethanol, mix thoroughly, then quickly add 40μL of aminosilane dropwise under magnetic stirring conditions, and magnetically stir overnight;
[0082] Put the mesoporous nano-zirconia particles stirred overnight into a centrifuge tube, centrifuge at a high speed (10000r / min, 10min), discard the supernatant, wash twice with 5mL of absolute ethanol and twice with 5mL of deionized water, and discard Remove the supernatant to obtain the aminated mesoporous nano-zirconia drug-loaded material;
[0083] Take 40mg of arsenic trioxide powder, mix thoroughly with 20mL of deionized water, stir overnight by magnetic force, fully dissolve the drug, and obtain arsenic trioxide solution;
[0084] Mix the above-mentioned arsenic trioxide solution into the above-mentioned aminated mesoporous nano-zirconia particles, under the condition of ultrasonic vibration (ultrasonic power is 50W, ultrasoni...
Embodiment 2
[0087] Take 20mg of mesoporous nano-zirconia particles, add 5mL of deionized water and 5mL of absolute ethanol, mix thoroughly, then quickly add 40μL of aminosilane dropwise under magnetic stirring conditions, and magnetically stir overnight;
[0088] Put the mesoporous nano-zirconia particles stirred overnight into a centrifuge tube, centrifuge at a high speed (10000r / min, 10min), discard the supernatant, wash twice with 5mL of absolute ethanol and twice with 5mL of deionized water, and discard Remove the supernatant to obtain the aminated mesoporous nano-zirconia drug-loaded material;
[0089] Take 40mg of arsenic trioxide powder, mix thoroughly with 20mL of deionized water, stir overnight by magnetic force, fully dissolve the drug, and obtain arsenic trioxide solution;
[0090] Mix the above-mentioned arsenic trioxide solution into the above-mentioned aminated mesoporous nano-zirconia particles, under the condition of ultrasonic vibration (ultrasonic power is 60W, ultrasoni...
Embodiment 3~5
[0093] The method in Examples 3-5 refers to the method in Example 1, the difference is that the amount or type of each substance, centrifugation or ultrasonic conditions, etc. are changed, and the specific condition changes are listed in Table 1.
[0094] Table 1 embodiment 3~5 concrete condition changes
[0095]
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