Calcium alginate-chitosan microspheres and preparation method thereof, drug-loaded calcium alginate-chitosan and preparation method thereof

A technology of chitosan microspheres and calcium alginate, which is applied in antibacterial drugs, microcapsules, drug delivery, etc., can solve the problems affecting the overall uniformity of drug carriers, wide particle size distribution of microspheres, and difficulty in precise control. Achieve the effect of easy and precise control, uniform particle size and convenient operation

Active Publication Date: 2021-06-25
WUYI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] One of purpose of the present invention is to provide a kind of preparation method of calcium alginate-chitosan microsphere, to improve adopting precipitation method and emulsification method to prepare microsphere drug carrier procedure loaded down with trivial details, microsphere particle size distribution is wider, easy to form Large particle size microspheres affect the overall uniformity of the drug carrier, leading to technical problems that are difficult to control accurately in the sustained and controlled release stage of the drug

Method used

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  • Calcium alginate-chitosan microspheres and preparation method thereof, drug-loaded calcium alginate-chitosan and preparation method thereof
  • Calcium alginate-chitosan microspheres and preparation method thereof, drug-loaded calcium alginate-chitosan and preparation method thereof
  • Calcium alginate-chitosan microspheres and preparation method thereof, drug-loaded calcium alginate-chitosan and preparation method thereof

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preparation example Construction

[0033] According to one aspect of the present invention, the present invention provides a method for preparing calcium alginate-chitosan microspheres, comprising the steps of: electrostatically spraying sodium alginate solution into a mixed solution of chitosan and calcium chloride , to obtain calcium alginate-chitosan microspheres.

[0034] In the preparation method of calcium alginate-chitosan microspheres provided by the present invention, the sodium alginate solution is sprayed into the mixed solution of chitosan and calcium chloride by electrostatic spraying, and the microspheres can be prepared, the process is simple, and the operation is convenient , and the particle size of the microspheres is uniform, and the particle size distribution is 20-50 μm, which makes it easier to control the slow and controlled release of the drug after it is loaded with the drug.

[0035] In a preferred embodiment of the present invention, the mass concentration of the sodium alginate solut...

Embodiment 1

[0084] The present embodiment provides a kind of calcium alginate-chitosan microsphere, and its preparation method comprises the steps:

[0085] (1) Prepare sodium alginate solution with water as solvent, the mass concentration of sodium alginate is 1.5%;

[0086] (2) Prepare a mixed solution of chitosan and calcium chloride with acetic acid as a solvent, wherein the concentration of chitosan is 0.2%, and the concentration of calcium chloride is 1%;

[0087] (3) The sodium alginate solution was sprayed into the mixed solution of chitosan and calcium chloride by electrostatic spraying at a spray speed of 4.5 mL / h;

[0088] (4) Centrifuge the solution in step (3) at a speed of 5000 rpm, remove the supernatant, and then wash with deionized water 3 times to obtain calcium alginate-chitosan microsphere suspension, freeze-dry , to obtain calcium alginate-chitosan microspheres.

Embodiment 2

[0090] This embodiment provides a kind of calcium alginate-chitosan microspheres, the difference of its preparation method and embodiment 1 is, in step (1), the mass concentration of sodium alginate solution is 4%; In (2), in the mixed solution of chitosan and calcium chloride, the mass concentration of chitosan is 0.05%, and the mass concentration of calcium chloride is 3%.

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Abstract

The present invention provides a kind of calcium alginate-chitosan microsphere and its preparation method, drug-loaded calcium alginate-chitosan and its preparation method, relate to the technical field of drug carrier, the calcium alginate-chitosan microsphere The preparation method comprises the steps of: spraying the sodium alginate solution into the mixed solution of chitosan and calcium chloride by electrostatic spraying to obtain calcium alginate-chitosan microspheres, and improving the microspheres prepared by the precipitation method and the emulsification method The technical problem of the slow and controlled release performance of the drug carrier is not good. The calcium alginate-chitosan microspheres provided by the present invention are prepared by electrostatic spraying. The process is simple, the operation is convenient, and the particle size of the microspheres is uniform. 20‑50μm, making it easier to precisely control the slow and controlled release of the drug after it is loaded with the drug.

Description

technical field [0001] The invention relates to the technical field of drug carriers, in particular to calcium alginate-chitosan microspheres and a preparation method thereof, drug-loaded calcium alginate-chitosan and a preparation method thereof. Background technique [0002] With the in-depth research on drug carrier systems, in recent years, microcapsules / spheres and other particulate drug controlled release systems have developed rapidly and have been widely used in clinical practice. [0003] At present, the methods for preparing microsphere drug carriers mainly include precipitation method and emulsification method. These methods have cumbersome procedures, and the particle size distribution of microspheres is wide. It is not easy to precisely control in the controlled release stage. [0004] In view of this, the present invention is proposed. Contents of the invention [0005] One of purpose of the present invention is to provide a kind of preparation method of ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/52A61K47/36A61K31/352A61P31/04A61P31/10
CPCA61K9/5036A61K31/352A61P31/04A61P31/10
Inventor 贾永堂苟琼友董凤春侯一杰王普凯谢娟
Owner WUYI UNIV
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