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Composition with effect of treating beriberi and application thereof

A composition and athlete's foot technology, applied in the directions of drug combinations, medical preparations containing active ingredients, plant raw materials, etc., can solve problems such as treatment failure, and achieve the effects of better curative effect, good antifungal activity, and strong practicability

Active Publication Date: 2021-08-10
湖北杏林春医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, drug-resistant strains can appear in the existing antifungal drugs, and drug resistance has become the main reason for the failure of clinical antifungal therapy.

Method used

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  • Composition with effect of treating beriberi and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1. A composition with the effect of treating beriberi, which comprises flavescens alkaloid 1g and hydra extract 1g.

[0022] The above extract of Hydrangea japonica is prepared by the following method: Take Hydracopodium, add 10 times the amount of water of the medicinal material, use the decoction method, extract 2 times, each time for 1 hour, filter, combine the extracts, and concentrate. .

[0023] The above matrine alkaloids are prepared by the following method: take matrine, add 12 times the sulfuric acid solution of 5% volume concentration to reflux extract twice, each time for 1.5 hours, combine the acid water extract, and add sodium hydroxide to alkalize to pH 10-11, then extract with chloroform three times, combine the chloroform extracts, concentrate to dryness, add water to disperse, pass through 732 strongly acidic styrene-based cation exchange resin column, wash with water until colorless, and then wash with ammonia water Take off, get the ammonia water el...

Embodiment 2

[0025] 1. A composition with the effect of treating beriberi, which comprises flavescens alkaloid 4g and hydra extract 1g.

[0026] The above extract of jasmine grass is prepared by the following method: take jasmine grass, add 12 times the amount of water of the medicinal material, use the reflux extraction method, extract 3 times, each time for 1 hour, filter, combine the extracts, and concentrate. .

[0027] The above matrine alkaloids are prepared by the following method: take matrine, add 10 times the hydrochloric acid solution of 5% volume concentration to reflux extract 3 times, each time for 1 hour, combine the acid water extract, and add sodium hydroxide to alkalize to pH 10-11, then extract with chloroform three times, combine the chloroform extracts, concentrate to dryness, add water to disperse, pass through 732 strongly acidic styrene-based cation exchange resin column, wash with water until colorless, and then wash with ammonia water Take off, get the ammonia wa...

Embodiment 3

[0029] 1. A composition with the effect of treating beriberi, which comprises 1 g of Sophora flavescens alkaloid and 4 g of Hydra herba extract.

[0030] The above extract of jasmine grass is prepared by the following method: take jasmine grass, add 8 times the amount of water of medicinal materials, use the reflux extraction method, extract 2 times, each time for 1.5 hours, filter, combine the extracts, and concentrate. .

[0031] The above matrine alkaloids are prepared by the following method: take matrine, add 8 times the hydrochloric acid solution of 5% volume concentration to reflux extract 3 times, each time for 1 hour, combine the acid water extract, and add sodium hydroxide to alkalize to pH 10-11, then extract with chloroform three times, combine the chloroform extracts, concentrate to dryness, add water to disperse, pass through 732 strongly acidic styrene-based cation exchange resin column, wash with water until colorless, and then wash with ammonia water Take off...

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Abstract

The invention discloses a composition capable of treating beriberi and its application. It is made from flavescens and hydra grass. Through a large number of experiments, the present invention screens out a composition mainly composed of Sophora flavescens and Hydra A single Sophora flavescens or Hydra flavescens at the same dose has better antifungal activity, is less prone to durability, has better curative effect, and has achieved good technical progress. The invention can be conveniently prepared into various external preparations and is convenient to use.

Description

technical field [0001] The invention relates to a composition with the effect of treating beriberi and its application. Background technique [0002] Tinea pedis (common name called athlete's foot) is caused by fungal infection, and its skin damage often occurs on one side (i.e. one foot) earlier, and then infects the opposite side after several weeks or months. Blisters mainly appear on the abdomen and sides of the toes, most commonly between the third and fourth toes, and can also appear on the soles of the feet. They are deep small blisters that can gradually merge into bullae. The skin lesions of tinea pedis have a characteristic, that is, the boundaries are clear and can gradually expand outwards. Due to the development of the disease or scratching, erosion, exudate, or even bacterial infection and pustules may appear. It brings great inconvenience to people's daily life. [0003] Existing antifungal drugs include azoles (including imidazoles, triazoles) and polyene ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/489A61P17/00A61P31/10
CPCA61P17/00A61P31/10A61K36/489A61K36/19A61K2236/00A61K9/10A61K2300/00
Inventor 杨洋
Owner 湖北杏林春医药科技有限公司
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