A weapon protection device designed to enclose a weapon and protect the weapon from adverse conditions, including water, dust, dirt and sand. The weapon protection device features a material that is durable and generally puncture resistant, impervious to water, lightweight, heat resistant and tear resistant. The weapon protection device is compact when not in use and requires very little storage space. The weapon protection device features one or more pockets having a flap and an interior region under the flap. The interior region is made of a flexible, stretchy material that allows a user to fire the weapon with either hand while the weapon is inside the protection device. The weapon can be used on short notice and does not require removal of the weapon from the weapon protection device. A waterproof opening seal, such as a dry sack seal, is provided.