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Composition with treatment effect on beriberi and application thereof

A composition and beriberi technology, applied in the direction of drug combination, medical preparations containing active ingredients, plant raw materials, etc., can solve problems such as treatment failure, and achieve the effect of strong practicability and convenient use

Active Publication Date: 2019-05-31
湖北杏林春医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, drug-resistant strains can appear in the existing antifungal drugs, and drug resistance has become the main reason for the failure of clinical antifungal therapy.

Method used

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  • Composition with treatment effect on beriberi and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1. A composition with the effect of treating beriberi, which comprises flavescens alkaloid 1g and hydra extract 1g.

[0022] The above extract of Hydrangea japonica is prepared by the following method: Take Hydracopodium, add 10 times the amount of water of the medicinal material, use the decoction method, extract 2 times, each time for 1 hour, filter, combine the extracts, and concentrate. .

[0023] The above matrine alkaloids are prepared by the following method: take matrine, add 12 times the sulfuric acid solution of 5% volume concentration to reflux extract twice, each time for 1.5 hours, combine the acid water extract, and add sodium hydroxide to alkalize to pH 10-11, then extract with chloroform three times, combine the chloroform extracts, concentrate to dryness, add water to disperse, pass through 732 strongly acidic styrene-based cation exchange resin column, wash with water until colorless, and then wash with ammonia water Take off, get the ammonia water el...

Embodiment 2

[0025] 1. A composition with the effect of treating beriberi, which comprises flavescens alkaloid 4g and hydra extract 1g.

[0026] The above extract of jasmine grass is prepared by the following method: take jasmine grass, add 12 times the amount of water of the medicinal material, use the reflux extraction method, extract 3 times, each time for 1 hour, filter, combine the extracts, and concentrate. .

[0027] The above matrine alkaloids are prepared by the following method: take matrine, add 10 times the hydrochloric acid solution of 5% volume concentration to reflux extract 3 times, each time for 1 hour, combine the acid water extract, and add sodium hydroxide to alkalize to pH 10-11, then extract with chloroform three times, combine the chloroform extracts, concentrate to dryness, add water to disperse, pass through 732 strongly acidic styrene-based cation exchange resin column, wash with water until colorless, and then wash with ammonia water Take off, get the ammonia wa...

Embodiment 3

[0029] 1. A composition with the effect of treating beriberi, which comprises 1 g of Sophora flavescens alkaloid and 4 g of Hydra herba extract.

[0030] The above extract of jasmine grass is prepared by the following method: take jasmine grass, add 8 times the amount of water of medicinal materials, use the reflux extraction method, extract 2 times, each time for 1.5 hours, filter, combine the extracts, and concentrate. .

[0031] The above matrine alkaloids are prepared by the following method: take matrine, add 8 times the hydrochloric acid solution of 5% volume concentration to reflux extract 3 times, each time for 1 hour, combine the acid water extract, and add sodium hydroxide to alkalize to pH 10-11, then extract with chloroform three times, combine the chloroform extracts, concentrate to dryness, add water to disperse, pass through 732 strongly acidic styrene-based cation exchange resin column, wash with water until colorless, and then wash with ammonia water Take off...

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Abstract

The invention discloses a composition with the treatment effect on beriberi and application thereof. The composition is prepared from radix sophorae flavescentis and peristrophe japonica. Through a large number of experiments, the composition using radix sophorae flavescentis and peristrophe japonica as main components is screened out. Anti-fungal experiment results show that the combination of radix sophorae flavescentis and peristrophe japonica can achieve synergistic interaction and anti-fungal effects, the composition has better anti-fungal activity than the single agent of radix sophoraeflavescentis or peristrophe japonica with the same dosage, drug tolerance is not easy to produce, the treatment effect is more excellent, and good technological progresses are made. The composition can be conveniently prepared into various external-use preparations and is convenient to use.

Description

technical field [0001] The invention relates to a composition with the effect of treating beriberi and its application. Background technique [0002] Tinea pedis (common name called athlete's foot) is caused by fungal infection, and its skin damage often occurs on one side (i.e. one foot) earlier, and then infects the opposite side after several weeks or months. Blisters mainly appear on the abdomen and sides of the toes, most commonly between the third and fourth toes, and can also appear on the soles of the feet. They are deep small blisters that can gradually merge into bullae. The skin lesions of tinea pedis have a characteristic, that is, the boundaries are clear and can gradually expand outwards. Due to the development of the disease or scratching, erosion, exudate, or even bacterial infection and pustules may appear. It brings great inconvenience to people's daily life. [0003] Existing antifungal drugs include azoles (including imidazoles, triazoles) and polyene ...

Claims

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Application Information

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IPC IPC(8): A61K36/489A61P17/00A61P31/10
CPCA61P17/00A61P31/10A61K36/489A61K36/19A61K2236/00A61K9/10A61K2300/00
Inventor 杨洋
Owner 湖北杏林春医药科技有限公司
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