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Medicine for preventing and controlling acetaminophen induced liver injury and application of medicine

A technology for acetaminophen and liver damage, applied in the field of medicine, can solve problems such as difficult quality control, high price of some components, complex prescription ingredients, etc., and achieve the effect of reducing limiting factors, reducing metabolic burden, and good preventive effect

Active Publication Date: 2019-06-21
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0005] The western medicine composition for the treatment of liver cirrhosis disclosed above must be used in combination with a variety of raw materials and oryzanol to achieve the purpose of treating liver cirrhosis. The composition of the prescription is complex, quality control is difficult, and some components are expensive

Method used

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  • Medicine for preventing and controlling acetaminophen induced liver injury and application of medicine
  • Medicine for preventing and controlling acetaminophen induced liver injury and application of medicine
  • Medicine for preventing and controlling acetaminophen induced liver injury and application of medicine

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Embodiment Construction

[0025] The technical solutions of the present invention will be clearly and completely described below in conjunction with specific embodiments. Apparently, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts fall within the protection scope of the present invention.

[0026] The invention discloses a medicine for preventing and controlling liver damage caused by acetaminophen and its application. The medicine is composed of oryzanol (ORY), and the oryzanol includes 43.07% cycloartenol ferulate, 41.67% 24-methylenecycloartenol ferulate and 6.22% campesterol ferulic acid ester, and other auxiliary materials such as starch, dextrin, sodium carboxymethyl starch and talcum powder.

[0027] Forty male Kunming mice weighing between 18-22 g were randomly divided into 4 groups, 10 i...

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Abstract

The invention relates to the technical field of medicines, in particular to a medicine for preventing and controlling acetaminophen induced liver injury and an application of the medicine. According to the medicine, acetaminophen induced liver injury can be effectively prevented by fewer types and less dosage of medicine raw materials, and the medicine comprises oryzanol.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a medicine for preventing and controlling liver damage caused by acetaminophen and its application. Background technique [0002] Acetaminophen (Acetaminophen, APAP) is a widely used antipyretic and analgesic drug, which is widely used clinically, especially in pediatrics. At the same time, acetaminophen is a hepatotoxic substance, and overdose can easily cause liver damage, which may further deteriorate into fatal liver failure. Currently, the antioxidant N-acetylcysteine ​​is mainly used to deal with APAP-induced liver injury. However, its therapeutic effect is unsatisfactory, and the side effects caused during the treatment process such as gastrointestinal discomfort, nausea, vomiting, central nervous system is affected leading to chills, dizziness, and respiratory bronchospasm, hemoptysis, etc. [0003] The Chinese invention patent with the publication number CN106511365A ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/575A61K31/167A61P1/16
Inventor 舒广文邱韵涵邓旭坤
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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