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Method for establishing animal model of radiation-induced colorectal inflammation

An animal model and a technology for establishing a method, which can be applied in the fields of restraining animals, preparation of test samples, medical science, etc. The effect of disease course mechanism research and drug development research, low animal mortality, and rigorous design

Inactive Publication Date: 2019-07-16
NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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Problems solved by technology

[0003] In view of this, the main purpose of the present invention is to provide a method for establishing an animal model of radiation-induced colitis, so as to solve the problem that there is no reliable, reasonable and clinical animal research model for current research on radiation-induced enteropathy

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  • Method for establishing animal model of radiation-induced colorectal inflammation
  • Method for establishing animal model of radiation-induced colorectal inflammation
  • Method for establishing animal model of radiation-induced colorectal inflammation

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Embodiment Construction

[0028] see below Figure 1 to Figure 5 Shown, carry out specific description to the establishment method of radiation colorectitis animal model of the present invention:

[0029] The present invention will provide a method for establishing an animal model of radiation-induced colitis that is close to clinical practice, and provide an animal model research basis for the study of the course mechanism of radiation-induced enteropathy and drug development.

[0030] materials needed:

[0031] The experimental animal of the present invention selects 30 SPF grade C57BL / 6 male mice (Guangdong Medical Experimental Animal Center) body weight 14 ± 1g, about 4-5 weeks in age, and is raised in the SPF grade environment of the animal center. This experiment obtains Hospital Ethics Committee permission.

[0032] Instrument equipment of the present invention selects medical electron linear accelerator (LA) model for use: U.S. VARIAN 23EX, and shadow plate (plexiglass plate), lead block are ...

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Abstract

The present invention provides a method for establishing an animal model of radiation-induced colorectal inflammation. The method comprises the following steps: mice are randomly divided into two large groups; the mice are normal fed for 1-2 weeks to enable the mice to be adapted to a new living environment; body positions of the mice during irradiation are simulated and an average value is taken;a radiotherapy plan is developed; depending on different group designs, a single large dose radiation is conducted using different doses of gradient rays; and severity of colorectal tissue lesions isassessed. Combining clinical practices, a common therapeutic ray (6MV X ray) used by a medical linear accelerator can better simulate radioactive colorectal injury lesion process of clinical radiotherapy side reactions, and besides, the method is low in animal mortality and simple and easy to repeat, provides an experimental basis for studying the radioactive colorectal injury, is convenient forfurther studying mechanism of the radioactive colorectal injury and guiding clinical medication, closer to clinical practice and more conducive to studying course mechanism of radiation enteritis anddrug development, and can also further expand use of a prevention and treatment technology applied in the radiation enteritis.

Description

technical field [0001] The invention relates to the technical field of animal model biomedicine, in particular to a method for establishing an animal model of radiation-induced colorectal inflammation. Background technique [0002] With the continuous improvement of medical technology, the role of radiation therapy in the comprehensive treatment of tumors has become increasingly prominent. About 70% of cancer patients need radiation therapy in the process of cancer treatment. Radiation therapy has become one of the main means of treating malignant tumors. one. With the obvious survival benefit brought by neoadjuvant chemoradiotherapy, there are more and more colorectal cancer survivors, and the number of patients with radiation-induced colitis has already exceeded the sum of patients with ulcerative colitis and Crohn's disease. Radiation colorectitis is a common intestinal complication after neoadjuvant radiotherapy for colorectal cancer. Although the radiation dose to norm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61D7/00A61D3/00G01N1/28G01N1/30G01N1/36G01N21/84
CPCA61D3/00A61D7/00A61D2003/006G01N1/286G01N1/30G01N1/36G01N21/84G01N2001/2873G01N2001/302G01N2001/305
Inventor 丁轶颜鸿妹李易奕许健柱罗经杰陈龙华
Owner NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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