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Method for Estimating Risk of Serious Eye Damage and Eye Irritation of Chemical Mixtures

A technology for mixtures and eye irritation, applied in the field of eye irritation risk estimation and serious eye damage of chemical mixtures

Active Publication Date: 2022-06-07
应急管理部化学品登记中心 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is that there is no method for estimating the risk of serious eye damage and eye irritation of chemical mixtures in the prior art, and a new method for estimating the risk of serious eye damage and eye irritation of chemical mixtures is provided, which has the advantages of The advantages of accurate estimates

Method used

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  • Method for Estimating Risk of Serious Eye Damage and Eye Irritation of Chemical Mixtures
  • Method for Estimating Risk of Serious Eye Damage and Eye Irritation of Chemical Mixtures
  • Method for Estimating Risk of Serious Eye Damage and Eye Irritation of Chemical Mixtures

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A method for estimating the risk of serious eye damage and eye irritation for a chemical mixture:

[0023] (1) Carry out data query on the serious eye damage / eye irritation data of all components of the mixture, and determine their serious eye damage / eye irritation classification. All serious eye damage / eye irritation components at levels ≥ 1% should be considered, for <1% serious eye damage / eye irritation components if still associated with serious eye damage / eye irritation of the mixture , should also be taken into account.

[0024] (2) Serious eye damage / eye irritation components in the mixture are grouped according to Category 1, Category 2.

[0025] (3) Check whether all serious eye damage / eye irritation components have a specific concentration limit value SCL in the catalog of hazardous chemicals. For components with a specific concentration limit value, use the specific concentration limit value SCL instead of the general concentration limit value GCL.

[0026]...

Embodiment 2

[0034] According to the method described in Example 1, a mixture contains three serious eye damage / eye irritation components, two of which have specific concentration limits and one without specific concentration limits. The specific contents and concentration limits are shown in the following table :

[0035]

[0036] The first step is to calculate compliance with the "Serious eye damage / eye irritation, Category 1" classification.

[0037] Because of the three components A, B, and C, A and B are "serious eye damage / eye irritation, category 1", and C is "serious eye damage / eye irritation, category 2", so component C cannot be used. To calculate the classification of "Serious eye damage / eye irritation, Category 1", the calculation is as follows:

[0038]

[0039] Therefore, the mixture is not classified as "Serious eye damage / eye irritation, Category 1".

[0040] The second step is to calculate whether it meets the classification of "serious eye damage / eye irritation, c...

Embodiment 3

[0047] According to the method described in Example 1, a mixture contains three serious eye damage / eye irritation components, two of which have specific concentration limits and one without specific concentration limits. The specific contents and concentration limits are shown in the following table :

[0048]

[0049] The first step is to calculate compliance with the "Serious eye damage / eye irritation, Category 1" classification.

[0050] Because of the three components A, B, and C, A and B are "serious eye damage / eye irritation, category 1", and C is "serious eye damage / eye irritation, category 2", so component C cannot be used. To calculate the classification of "Serious eye damage / eye irritation, Category 1", the calculation is as follows:

[0051]

[0052] Therefore, the mixture is not classified as "Serious eye damage / eye irritation, Category 1".

[0053] The second step is to calculate whether it meets the classification of "serious eye damage / eye irritation, c...

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Abstract

The invention relates to a method for estimating the risk of serious eye damage and eye irritation of chemical mixtures, which mainly solves the problem that there is no method for estimating the risk of serious eye damage and eye irritation of chemical mixtures in the prior art. The present invention adopts a method for estimating the risk of serious eye damage and eye irritation of a chemical mixture, including: (1) if a mixture has not been tested for damage and irritation to the eyes of animals, and there is no similar mixture data for reference, The mixture is classified according to the serious eye damage / eye irritation data of the components in the mixture; (2) The following formula is used for calculation: (3) The estimated results determine whether it is classified as "serious eye damage / eye irritation, Category 1" , "Serious eye damage / eye irritation, category 2" is judged based on whether the final calculation result is ≥ 1. The technical solution solves the above problems well, and can be used in the risk estimation of serious eye damage and eye irritation of chemical mixtures.

Description

technical field [0001] The invention relates to a method for estimating the risk of serious eye damage and eye irritation of chemical mixtures. Background technique [0002] In recent years, my country's implementation of GHS has issued a series of standards, including 16 physical hazards, 10 health hazards and 2 environmental hazards. "Serious eye damage / eye irritation" is a health hazard primarily used to determine the level of ocular tissue damage or irritation following exposure to chemicals applied to the front surface of the eye. [0003] The current classification mainly obtains data through animal serious eye injury / eye irritation test, or uses bridging principle for analysis. For mixtures for which there are no overall data and the bridging principle cannot be used, a critical concentration is usually used. The cut-off value is divided into a general concentration limit value and a specific concentration limit value. The general concentration limit value is set in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16C20/30
CPCG16C20/30Y02P90/30
Inventor 张金梅高月于天玲徐鹏飞宋扬刘奥林王睿
Owner 应急管理部化学品登记中心