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Artificial corneas containing biomaterials

A technology of artificial cornea and biomaterials, applied in the field of medicine, to reduce the chance of entering the eye, reduce foreign body reactions, and facilitate large-scale promotion and use

Active Publication Date: 2021-09-24
THE THIRD MEDICAL CENT OF THE CHINESE PEOPLES LIBERATION ARMY GENERAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The main purpose of the present invention is to overcome the above-mentioned defects in the existing artificial cornea, and provide an artificial cornea containing biomaterials and an implantation method to enhance the biointegration of the artificial cornea and reduce the artificial cornea during use. discharge and reduce the incidence of infection

Method used

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  • Artificial corneas containing biomaterials
  • Artificial corneas containing biomaterials
  • Artificial corneas containing biomaterials

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0067] The present invention uses the exposure rate of the artificial corneal stent to evaluate the implementation effect of the artificial cornea of ​​the present invention, and the exposure rate is also the rejection rate. According to the applicant's experience of using MICOF and Boston type II artificial corneas, the exposure rate (rejection rate) of patients implanted with existing PMMA artificial corneas without biomaterial components is 60% 5 years after the operation. However, the applicant performed a total of 156 cases of artificial cornea implantation operations containing autologous ear cartilage. As a result, only 6 cases were exposed after 5 years, and the exposure rate dropped to 3.8%.

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Abstract

The invention discloses a biomaterial-containing artificial cornea, which includes an optical part and a biomaterial component, the biomaterial component is composed of biomaterial, and the biomaterial includes autologous material and / or non-autologous material. The new artificial cornea of ​​the present invention has good biocompatibility, optical performance and mechanical strength performance, and is suitable for various complicated and severe corneal blindness treatment. It can use the patient's own cornea or the donor cornea as a carrier, which is convenient and large. Use on a large scale.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a novel artificial cornea containing biomaterials. Background technique [0002] According to the World Health Organization (WHO) report in 2009, there are about 8 million patients with corneal blindness in the world. There are about 3 million corneal blind patients in my country. Penetrating keratoplasty is currently the main means of vision recovery for corneal blindness, and the 5-year success rate for low-risk lesions can reach 70%. However, for high-risk cases with a large number of corneal neovascularization, etc., the success rate is less than 50%, especially for severe corneal scars, vascularization, infection or immune diseases caused by severe acid-base chemical burns or eyelids that cannot be restored. Conjunctival sac dysfunction, such as complete obliterated symblephane, Steven-Johnson syndrome (SJS), ocular cicatricial pemphigoid (OCP), and multiple keratoplasty ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/14A61L27/50
CPCA61F2/142A61F2210/00A61F2210/0004A61L27/50A61L2430/16
Inventor 王丽强黄一飞
Owner THE THIRD MEDICAL CENT OF THE CHINESE PEOPLES LIBERATION ARMY GENERAL HOSPITAL
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