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38 results about "Donor cornea" patented technology
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Method of lifting an epithelial layer and placing a corrective lens beneath it
This relates to a lens made of donor corneal tissue suitable for use as a contact lens or an implanted lens, to a method of preparing that lens, and to a technique of placing the lens on the eye. The lens is made of donor corneal tissue that is acellularized by removing native epithelium and keratocytes. These cells optionally are replaced with human epithelium and keratocytes to form a lens that has a structural anatomy similar to human cornea. The ocular lens may be used to correct conditions such as astigmatism, myopia, aphakia, and presbyopia.
Owner:TISSUE ENG REFRACTION
Ophthalmic surgical instrument & surgical methods
Surgical instruments and their methods of use enable a surgeon to form a precut lamellar disk that is removed by the same through a single incision along the perimeter of the cornea. This may be done using one this one instrument. Another instrument enables the surgeon to scrap off adhering parts. One more instrument enables the surgeon to hold a folded cornea donor disk to avoid inverting the disk upon unfolding. Yet another instrument enables the surgeon to “iron out” wrinkles in the implanted donor cornea.
Owner:JOHN THOMAS
System and method for descemet's stripping automated endothelial keratoplasty (DSAEK) surgery
The system for donor cornea implantation includes a preparation base having a well for receiving a posterior lamellar donor corneal lenticule, a cartridge disengageably mounted on the base adjacent the well, and a handle for disengageable attachment to a posterior end portion of the cartridge. In drawing the donor lenticule from the well into and through a bore or chamber of the cartridge, from the posterior end, the lenticule is caused to assume a double coil configuration. After attachment of the handle, removal of the assembly from the preparation base, and insertion of blade and adjacent body portions of the cartridge through an incision in the cornea, the coiled donor lenticule is pulled from the cartridge bore through its forward end, to uncoil automatically within the anterior chamber of the recipient's eye.
Owner:WESTON PHILIP DOUGLAS +2
Method and apparatus of cornea examination
InactiveUS20050213037A1Improve abilitiesImprove accuracyEye implantsOptically investigating flaws/contaminationDigital videoEntire cornea
This invention comprises an improvement on the examination and evaluation of donor corneas. The improved apparatus includes the incorporation of a diffused light source, or sources, which are placed posteriorly to a donor cornea, with a viewing means placed anteriorly to said cornea. The apparatus involves the addition of the diffused light sources to existing apparatus, as well as the possible incorporation of a digital video camera or other electronic viewing means, which was not usable under the prior art. The method of placement of the diffused light source or sources is also novel, as compared with the prior art. Using this apparatus and method, the diffused light passes through the cornea, and is received by the viewing means. The viewing means is able to capture and image of the cornea, where the diffused light denotes any imperfections to the cornea. Use of the diffused light allows a complete view of the entire cornea at one time. The view of the cornea may be captured using a digital video camera or other means, with the image capable of being transmitted to another viewer, or where the entire examination can be done using a high resolution monitor.
Owner:ABDULLAYEV ERKIN +1
Regenerative prostheses as alternatives to donor corneas for transplantation
The present disclosure relates to a corneal implant comprising a matrix material and a core part wherein the core part is arranged essentially in the middle of the matrix material. The core part is anti fouling in order to stop cell proliferation across said part. The present disclosure further relates to a method of preparing the said product and the use of the same.
Owner:UAB FERENTIS
Apparatus and method for in vitro storage of a cornea
InactiveUS7662611B2Simple downward pressureAid stabilization and securitizationSnap fastenersBioreactor/fermenter combinationsLocking mechanismEngineering
A fixture and method is provided for in vitro storage of a cornea. The fixture includes a platform having a corneal-sceral rim receiving surface, a clamp having a mating surface for the cornel-scleral rim and handles. A locking mechanism is provided to secure a donor cornea between the clamp and platform. The combination cornea, platform and clamp are placed in a storage unit having a fluid preservation media. In one embodiment, the storage unit includes a vial having an optically clear closed end and an opened end. A lid is secured to the open end of the vial and engages the handles in order to stabilize the clamped cornea within the vial.
Owner:CLEO COSMETIC & PHARMA
Corneal punch
A corneal punch comprising a base unit having a first annular mating surface surrounding a well in which a donor cornea may be located, and a separate guide unit including an inner annular guide shaft and an outer locating ring connected to the guide shaft and having a second annular mating surface. The base unit and the guide unit may be releasably positioned in registration with each other by way of the first and second mating surfaces such that the guide shaft is substantially coaxial with the well.
Owner:NETWORK MEDICAL PRODS
Fluorescent quantitative PCR (Polymerase Chain Reaction) detection kit and detection method of HBV (Hepatitis B Virus) and TP (Treponema Pallidum) of donor corneas
ActiveCN101851687ARealize detectionAvoid cross contaminationMicrobiological testing/measurementFluorescence/phosphorescenceConjunctivaPositive control
The invention relates to a fluorescent quantitative PCR detection kit and a detection method of HBV and TP of donor corneas. The kit comprises a DNA (deoxyribonucleic acid) extraction reagent, a DNA amplification reagent and positive working standards, wherein the DNA amplification reagent comprises a premix reagent, a 20X fluorescent probe reinforcing agent, forward and reverse HBV primers, an HBV fluorescent probe, forward and reverse TP primers, a TP fluorescent probe, distilled water of ribose-free nuclease and HBV and TP negative control and positive control; the positive working standards are pUC57-HBV plasmids containing destination sequences amplified by the forward and reverse HBV primers and a pUC57-TP plasmids containing destination sequences amplified by the forward and reverse TP primers. The invention realizes the complete closed-tube detection on donor conjunctiva tissue specimens and does not need PCR aftertreatment, and thereby, cross contamination is avoided; meanwhile, real-time detection is adopted, and an obtained Ct value and the original template number are completely in linear correlation; the quantitative accuracy rate is extremely high, and the relative error is about 50 percent, and thereby, the invention is enough to adapt to the demands of clinical nucleic acid quantification.
Owner:SHANDONG EYE INST
Method for harvesting corneal donor plugs for use in keratophakia procedures
A method for harvesting a plurality of corneal donor plugs for use in keratophakia procedures requires the determination of a perimeter for the plurality of plugs. Further, the method involves the selection of posterior and anterior boundaries for the plurality of donor plugs. In the method, interfaces between adjacent donor plugs are identified. Thereafter, a pulse laser beam is directed along the perimeter, the boundaries and the interfaces to establish the plurality of plugs. After the plugs are removed from the donor cornea, individual plugs are mechanically separated from one another.
Owner:TECHNOLAS PERFECT VISION
Apparatus and method for in vitro storage of a cornea
InactiveUS20060110721A1Simple downward pressureAid stabilization and securitizationSnap fastenersBioreactor/fermenter combinationsLocking mechanismEngineering
A fixture and method is provided for in vitro storage of a cornea. The fixture includes a platform having a corneal-sceral rim receiving surface, a clamp having a mating surface for the cornel-scleral rim and handles. A locking mechanism is provided to secure a donor cornea between the clamp and platform. The combination cornea, platform and clamp are placed in a storage unit having a fluid preservation media. In one embodiment, the storage unit includes a vial having an optically clear closed end and an opened end. A lid is secured to the open end of the vial and engages the handles in order to stabilize the clamped cornea within the vial.
Owner:CLEO COSMETIC & PHARMA
Membrane non-uniformity biological material transparency screening method and decellularized dermal matrix
ActiveCN109324001AHigh transparencySolve the contradiction of shortageColor/spectral properties measurementsTissue regenerationLamellar keratoplastyScreening method
The invention discloses a membrane non-uniformity biological material transparency screening method. The membrane non-uniformity biological material transparency screening method comprises the steps of biological material saccharose dehydration, OCT embedding, layer-by-layer frozen section, transparency measurement by using a spectrophotometer and the like. The invention also provides a high-transparency decellularized dermal matrix obtained by using the method. Through the invention, the decellularized dermal matrix with optimal transparency can be screened effectively, the decellularized dermal matrix can be used for lamellar keratoplasty, the matrix can be used for replacing an existing lamellar cornea matrix in the operation by an operating doctor, and the contradiction of donor corneashortage at present can be further solved effectively while the cornea diseases of patients are cured.
Owner:PEKING UNIV THIRD HOSPITAL
Fluorescent quantitative PCR (Polymerase Chain Reaction) detection kit and detection method of various viruses of donor corneas
ActiveCN101851686AAvoid cross contaminationImprove Quantitative AccuracyMicrobiological testing/measurementFluorescence/phosphorescenceConjunctivaPositive control
The invention relates to a fluorescent quantitative PCR detection kit and a detection method of various viruses of donor corneas. The kit comprises an RNA (Ribonucleic Acid) extraction reagent, an RNA reverse transcription and amplification reagent and positive working standards, wherein the RNA reverse transcription (RT) and amplification reagent comprises a 2X RT-PCR premix reagent, polymerases, reverse transcriptases, forward and reverse HCV (hepatitis C virus) primers, an HIV1 (human immunodeficiency virus 1) primer, an RV (rubella virus) primer, HCV, HIV1 and RV fluorescent probes and HCV, HIV1 and RV negative and positive control; the positive working standards are pUC57-HCV plasmids containing destination sequences amplified by the HCV forward and positive primers and pUC57-HIV1 plasmids containing destination sequences amplified by the HIV1 forward and positive primers respectively. The invention realizes the complete closed-tube detection on donor conjunctiva tissue specimens and does not need PCR aftertreatment, and thereby, cross contamination is avoided; meanwhile, real-time detection is adopted and an obtained Ct value and the original template number are completely in linear correlation; the quantitative accuracy rate is extremely high, and the relative error is about 50 percent, and thereby, the invention is enough to adapt to the demands of clinical nucleic acid quantification.
Owner:SHANDONG EYE INST
Donor corneal cutting blade
A donor corneal tissue cutting blade provided with integrally formed asymmetrical markers for facilitation identification of the anterior and posterior sections or portions of the donor corneal tissue is disclosed. The blade is a cylindrical body having, in one embodiment, a U-shaped extension which cooperates with the body to define a keyway. Protrusions may be formed on the body and / or extension to provide further markers.
Owner:BARRON PRECISION INSTR
System and method for resecting corneal tissue
A system and method of resecting corneal tissue for transplantation is disclosed. In each of the recipient cornea and the donor cornea, an annular incision is made at a predetermined incision depth. A first sidecut incision is made in each cornea, running from the outer periphery of the annular incision to one of the anterior corneal surface or the posterior corneal surface. The first sidecut incision forms an acute angle with the annular incision. A second sidecut incision is also made in each cornea, running from the inner periphery of the annular incision to the other of the anterior corneal surface or the posterior corneal surface. The second sidecut incision forms an acute angle with the annular incision. The combination of the incisions in each cornea resects corneal tissue from the recipient cornea and donor tissue from the donor cornea. The donor tissue is grafted into the recipient cornea.
Owner:AMO DEVMENT
Regenerative prostheses as alternatives to donor corneas for transplantation
The present invention relates to a corneal implant comprising a matrix material and a core part wherein the core part is arranged essentially in the middle of the matrix material. The core part is anti fouling in order to stop cell proliferation across said part. The present invention further relates to a method of preparing the said product and the use of the same.
Owner:UAB FERENTIS
Artificial anterior chamber for use in keratoplasty
InactiveUS20070129741A1Secure retentionThe process is convenient and fastEye implantsEye surgeryEpikeratoplastyEngineering
There is disclosed a device for retaining a donor cornea when cutting a donor button. The device comprises a base unit having a hollow cylindrical pedestal projecting therefrom, the pedestal having a central axis and an end remote from the base unit defining an annular basal surface adapted to receive a donor cornea. There may be provided cross-hair means for visually indicating a position of the central axis of the pedestal, and removable retaining means adapted to fit snugly over the pedestal so as to retain the donor cornea securely in position on the end of the pedestal.
Owner:WESTON PHILIP DOUGLAS
Donor corneal cutting blade
A donor corneal tissue cutting blade provided with integrally formed asymmetrical markers for facilitation identification of the anterior and posterior sections or portions of the donor corneal tissue is disclosed. The blade is a cylindrical body having, in one embodiment, a U-shaped extension which cooperates with the body to define a keyway. Protrusions may be formed on the body and / or extension to provide further markers.
Owner:BARRON PRECISION INSTR
Limited depth corneal punch
A single-use adjustable depth trephine corneal punch device that allows a goal trephination depth of a donor cornea to be set and cut prior to a surgical procedure for cutting selected portions of an actual patient cornea. The corneal punch includes a punch block having a central well for receiving a donor cornea, a punch top mounted atop the punch block and having a central cylindrical opening coaxially aligned with the well, and means for cutting a selected portion of the donor cornea in the central well, wherein the means for cutting includes a punch blade mounted atop the punch top and through the opening for combined limited rotation less than about 312 degrees and limited axial movement from a reference or “start” point and into juxtaposed relation against the cornea and a limited axial downward movement during rotation wherein to make a shallow cut in the cornea.
Owner:BARRON PRECISION INSTR
Corneal graft implanter for corneal transplantation
The utility model relates to the technical field of corneal transplantation surgical instruments, in particular to a corneal graft implanter for corneal transplantation surgery, which comprises an implanter element, a connecting hose, a bottle cap, a bottle body and an injector, the bottle cap comprises a cap body and a push-pull plunger device, the push-pull plunger device comprises a plunger rod, a plunger and a plunger cylinder, and the plunger rod is connected with the connecting hose. One end of the plunger rod is fixedly connected with the cover body, the other end of the plunger rod penetrates through the top of the plunger cylinder in an airtight mode and is fixedly connected with a plunger matched with the plunger cylinder in the plunger cylinder, and a connecting pipe is arranged at the bottom of the plunger cylinder. And the connecting hose is used for connecting the top of the implanter element with the connecting pipe or the injection port of the injector. The implanter is used for pre-loading a donor cornea graft; the donor corneal graft is stored and transported to an operation position of a patient in a sterile mode and can be directly taken and used, and the donor corneal endothelial cell loss is avoided to the greatest extent in the receiving and implanting process of the donor corneal graft; meanwhile, a small-incision cornea transplantation operation is carried out through the implanter, and convenient transplantation is provided for ophthalmologists.
Owner:QINGDAO CAIHUI BIOTECHNOLOGY CO LTD
Limited depth corneal punch
A single-use adjustable depth trephine corneal punch device that allows a goal trephination depth of a donor cornea to be set and cut prior to a surgical procedure for cutting selected portions of an actual patient cornea. The corneal punch includes a punch block having a central well for receiving a donor cornea, a punch top mounted atop the punch block and having a central cylindrical opening coaxially aligned with the well, and means for cutting a selected portion of the donor cornea in the central well, wherein the means for cutting includes a punch blade mounted atop the punch top and through the opening for combined limited rotation less than about 312 degrees and limited axial movement from a reference or “start” point and into juxtaposed relation against the cornea and a limited axial downward movement during rotation wherein to make a shallow cut in the cornea.
Owner:BARRON PRECISION INSTR
Corneal Inlay And Pinhole Lens Structure For Implantation Into A Cornea Of An Eye
A corneal inlay and pinhole lens structure for implantation into a cornea of an eye is disclosed herein. In one embodiment, a corneal inlay for implantation into a cornea of an eye includes an inlay body formed from natural tissue of a donor cornea; and a central pinhole disposed in the inlay body, the central pinhole being surrounded by a darkened bounding wall. In another embodiment, a pinhole lens structure includes an insertable pinhole body defining a through pinhole of approximately 0.9-2.0 mm in diameter with a surrounding darkened wall having an approximately 0.1-1 mm wall thickness, the insertable pinhole body configured to be inserted into a corneal pocket in a cornea of an eye.
Owner:PEYMAN GHOLAM A
Device to facilitate performing descemet's membrane endothelial keratoplasty (DMEK)
PendingUS20200060808A1Reduce deliveryEasy to masterEye implantsEye surgeryDescemets MembraneOphthalmology
An embodiment in accordance with the present invention provides a device and method for performing Descemet's membrane endothelial keratoplasty (DMEK). The device includes a tray for loading a corneal graft, a permeable cap, and a handle for facilitating delivery of the corneal graft into the eye of the recipient. The tray is configured such that the corneal graft is tri-folded on the tray or folded on the donor cornea. The permeable cap allows for hydration and protection of the graft during transit. When it is time to deliver the corneal graft into the eye of the recipient, the tray can be loaded onto the handle after the caps are be removed. A method according to the present invention includes a corneal graft being loaded onto the tray, covered with the permeable cap, and transmitted to the facility doing the corneal transplant.
Owner:THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE
Fluorescent quantitative PCR (Polymerase Chain Reaction) detection kit and detection method of HBV (Hepatitis B Virus) and TP (Treponema Pallidum) of donor corneas
ActiveCN101851687BRealize detectionAvoid cross contaminationMicrobiological testing/measurementFluorescence/phosphorescenceFluoProbesA-DNA
Owner:SHANDONG EYE INST
Limited depth corneal punch
A single-use adjustable depth trephine corneal punch device that allows a goal trephination depth of a donor cornea to be set and cut prior to a surgical procedure for cutting selected portions of an actual patient cornea. The corneal punch includes a punch block having a central well for receiving a donor cornea, a punch top mounted atop the punch block and having a central cylindrical opening coaxially aligned with the well, a punch blade mounted atop the punch top and through the opening cooperates with the top for combined limited rotation and limited axial movement from a reference or “start” point and into juxtaposed relation against the cornea and a limited axial downward movement during rotation to make a shallow cut in the cornea.
Owner:BARRON PRECISION INSTR
Generation and cryopreservation of pluripotent stem cell-derived clinical grade corneal endothelial cells
Human embryonic stem cell (hESC)- and induced pluripotent stem cell (iPSC)-derived clinical-grade corneal endothelial cells (CECs) generation and cryopreservation through the neural crest cell (NCC) lineage using peripheral blood as a donor source and hESCs maximizes the availability of these vital cells for treating the corneal endothelial disease as an alternative to donor corneas for corneal endothelium (CE) transplantations and other applications.
Owner:JOHNS HOPKINS UNIVERSITY
Screening method for transparency of membranous heterogeneous biomaterials and acellular dermal matrix
ActiveCN109324001BHigh transparencySolve the contradiction of shortageColor/spectral properties measurementsTissue regenerationDiseaseCorneal disease
The invention discloses a method for screening the transparency of a film-shaped heterogeneous biological material, which comprises the steps of dehydration of the biological material sucrose, OCT embedding, layer-by-layer frozen sectioning, and light transmittance measurement with a spectrophotometer. Also provided is a highly transparent decellularized dermal matrix obtained by the above method. Through the present invention, the acellular dermal matrix with the best transparency can be effectively screened out, which can be used for lamellar keratoplasty, and the surgeon can use the above-mentioned matrix to replace the existing lamellar corneal stroma during the operation. At the same time, it can also effectively solve the contradiction of the current shortage of donor corneas.
Owner:PEKING UNIV THIRD HOSPITAL
Intracorneal ring supported graft and method for cornea regeneration
InactiveUS20210177573A1Prevent corneal meltingReduce curvatureEye implantsEye surgeryPolymethyl methacrylateMethacrylate methyl
An intracorneal ring made of a polymer compatible with corneal metabolism such as polymethyl methacrylate (PMMA) in cooperation with a corneal graft for adjusting the topography and increasing the thickness of cornea. The ring is a full circle with two spherical or aspherical side surfaces defining its thickness, and an inner and an outer rim defining its width. A plurality of holes distributed around the ring pass through the thickness. A donor corneal graft sutured to the ring via the holes and stretched flat by the suture, fills the inside of the ring. The integrated ring, graft, and suture called as ring graft is inserted in the cornea stroma using superior scleral tunnel incision to correct the shape of the cornea and improve visual acuity. The ring supports the graft circumferentially and promotes its bonding with stroma. The supported graft reshapes and regenerates the cornea. The invention is applicable to treating mild to severe keratoconus, ectasia and other cornea disorders. The ring graft also increases the thickness and strength of cornea, which additionally slows down the progress of keratoconus. There is post operation potential for further visual acuity improvement with refractive correction procedures such as customized PRK. The ring has an outer rim diameter of nearly the normal diameter of cornea and acts as an auxiliary limbus providing additional support to the cornea.
Owner:JADIDI KHOSROW +1
Systems and methods for corneal transplants
ActiveUS20180344450A1Improve stabilityReduce the possibilityEye implantsEye treatmentTissue materialAnterior surface
Corneal transplant procedures may involve suturing an implant of healthy corneal tissue to a recipient cornea. The sutures may cause unwanted deformation of the corneal implant and the recipient cornea. A supporting structure may be embedded into the corneal implant to enhance the stability of the corneal implant and the recipient cornea and to reduce the likelihood of unwanted deformation when the corneal implant is sutured to the recipient cornea. According to one embodiment, a corneal implant includes donor corneal tissue extracted from a donor cornea. The donor corneal tissue includes an interior channel formed at a depth below an anterior surface. The corneal implant includes a supporting structure formed from non-tissue material and positioned in the channel.
Owner:CORNEAGEN INC
Corneal treatment
Systems and methods produce implants for treating keratoconus or other eye disorders. An example method includes identifying a subject with keratoconus. The method includes obtaining, with assessment means, an assessment of a cornea of a subject; determining, by processor(s), inverse measurements for correcting one or more irregularities associated with the keratoconus based on the assessment; and shaping, with a laser system, a donor cornea according to a pattern based on the inverse measurements. The example method may further include determining smoothing effects associated with the cornea, wherein the inverse measurements are based further on the smoothing effects, and the pattern for shaping the donor cornea is based further on the smoothing effects. Obtaining the assessment of the cornea may include obtaining a topographic measurement, a tomographic measurement, anterior segment optical coherence tomography (OCT), Scheimpflug imaging, an epithelium mapping, a stromal thickness mapping, and / or one or more biomechanical measurements.
Owner:ALLOTEX INC
Donor cornea trephine
The utility model relates to the technical field of medical instruments, in particular to a donor cornea trephine which comprises a carrying table, a pressure ring base and a drilling tool base. A trephine inner cavity is formed in the carrying table, an annular groove is formed in the middle of the upper surface of the carrying table, a center hole is formed in the center of the bottom face of the annular groove, first air holes and positioning air holes are evenly distributed around the center hole, and the first air holes are used for adsorbing corneas; when the cornea is adsorbed, the pressure ring base is positioned above the carrying table and is used for sealing the positioning air hole; when cornea cutting is carried out, the drilling tool base is located above the carrying table, a second through hole is formed in the middle of the drilling tool base, and a drilling tool used for cutting the cornea of a donor is arranged in the second through hole. When negative pressure is generated in the inner cavity of the trephine, the pressure ring base seals the positioning air hole, the first air hole adsorbs a donor cornea, the donor cornea is tensioned and flatly attached to the bottom face of the annular groove, and the phenomenon that the cutting diameter and the regular circle of a drilling tool are affected due to the fact that the donor cornea folds is avoided.
Owner:AUTEK CHINA