Combination drug suitable for treatment and prevention of non-alcoholic fatty liver disease (naflad) and/or non-alcoholic steatohepatitis (NASH), and/or hepatic steatosis

A technology for fatty liver disease and hepatic steatosis, applied to active ingredients of sulfur/selenium/tellurium, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve problems such as unconfirmed effectiveness of zinc preparations

Active Publication Date: 2019-08-06
北京通复堂生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This demonstrates the combined effect of a number of pancreatin and zinc (polyprezin), but no effect of zinc (polyprezin) on nonalcoholic fatty liver disease (NAFLAD) and / or nonalcoholic fatty Effective for acute hepatitis (NASH)

Method used

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  • Combination drug suitable for treatment and prevention of non-alcoholic fatty liver disease (naflad) and/or non-alcoholic steatohepatitis (NASH), and/or hepatic steatosis
  • Combination drug suitable for treatment and prevention of non-alcoholic fatty liver disease (naflad) and/or non-alcoholic steatohepatitis (NASH), and/or hepatic steatosis
  • Combination drug suitable for treatment and prevention of non-alcoholic fatty liver disease (naflad) and/or non-alcoholic steatohepatitis (NASH), and/or hepatic steatosis

Examples

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Comparison scheme
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Embodiment

[0071] Although an Example is given and this invention is demonstrated in more detail, this invention is not limited to an Example at all.

[0072] Example

[0073] The NASH model mice were divided into four groups (8 mice / group) by weight-stratified random extraction method in the manner of equal average body weight. The four groups were zinc preparation (polyprex zinc) + selenium preparation (sodium selenite) group, zinc complex preparation (polyprex zinc) group alone, selenium preparation (sodium selenite) group alone, control group. The administration route was oral administration, and the administration period was 28 days.

[0074] The frequency of administration was set to once a day. The dose was set at 10 ml / kg body weight, and administered using an oral probe.

[0075] Table 1 shows the dosage of each group.

[0076] [Table 1]

[0077]

[0078] At the end of the administration, blood was collected from the heart under ether anesthesia. The obtained serum was...

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Abstract

The issue of the invention is to provide a pharmaceutical product and health food that are suitable for treatment and prevention of hepatitis virus-unrelated non-alcoholic fatty liver disease (NAFLAD)and / or non-alcoholic steatohepatitis (NASH), and / or hepatic steatosis. To solve the issue, a combination drug which contains a zinc preparation and a selenium preparation as active ingredients, and which is suitable for treatment of non-alcoholic fatty liver disease (NAFLAD) and / or non-alcoholic steatohepatitis (NASH), and / or hepatic steatosis is provided.

Description

technical field [0001] The invention relates to a medical compound preparation and health food suitable for the treatment and prevention of nonalcoholic fatty liver disease (NAFLD) and / or nonalcoholic steatohepatitis (NASH). [0002] In further detail, the present invention relates to a compound preparation of a zinc preparation and a selenium preparation for the treatment of nonalcoholic fatty liver disease (NAFLAD) and / or nonalcoholic steatohepatitis (NASH), wherein the zinc preparation is especially polyprem Zinc (Polaprezinc), selenium preparations, especially sodium selenite, and zinc preparations and selenium in the treatment of diseases associated with or accompanying nonalcoholic fatty liver disease (NAFLAD) and / or nonalcoholic steatohepatitis (NASH) Compound preparations of preparations, wherein the zinc preparation is especially polyprezinc, and the selenium preparation is especially sodium selenite. It also relates to zinc preparations defined in this description, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/30A23L33/16A61K33/04A61P1/16
CPCA23L33/16A61K33/04A61P1/16A61K31/355A61K9/0053A61K31/4164A61K31/315A61K2300/00
Inventor 久保田悟河野透
Owner 北京通复堂生物科技股份有限公司
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