A novel composition for nonalcoholic fatty liver disease (NAFLD)

a technology for fatty liver disease and composition, applied in the field of novel composition for nonalcoholic fatty liver disease, can solve the problems of increased prevalence of steatohepatitis in non-insulin-dependent diabetes mellitus, weight loss, obesity patients who lost weight before death, etc., and achieve the effect of advanced liver scarring and advanced liver scarring

Inactive Publication Date: 2016-06-16
CADILA HEALTHCARE LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention relates to methods and compositions for treating different forms of chronic liver diseases such as non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and advanced scarring of the liver (cirrhosis). More specifically, this invention involves the use of a specific compound called Compound A that can reduce inflammation and fibrogenesis in the liver tissue, thereby promoting healing and reducing damage caused by these chronic conditions. This compound has been found to be safe and well tolerated when used at therapeutic doses in humans.

Problems solved by technology

The technical problem addressed in this patent text is the need for a treatment for nonalcoholic fatty liver disease (NAFLD) and particularly nonalcoholic steatohepatitis (NASH). NAFLD and NASH are frequently reported in obese patients and are characterized by fat accumulation, tissue degeneration, inflammation, cell degeneration, fibrosis, and even cirrhosis. Currently, weight loss is the common prescription, but it is difficult to determine the effect of a reduction in weight on NASH because obese patients often do not maintain significant weight reduction. Therefore, there is a need to find a more effective treatment for NAFLD and NASH.

Method used

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  • A novel composition for nonalcoholic fatty liver disease (NAFLD)
  • A novel composition for nonalcoholic fatty liver disease (NAFLD)
  • A novel composition for nonalcoholic fatty liver disease (NAFLD)

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Embodiment Construction

[0019]The present invention describes a pharmaceutical composition for reduction and removal of lipid accumulated in the liver cells (hepatocytes), required for treating and preventing certain diseases and conditions in subject suffering from nonalcoholic fatty liver disease (NAFLD) including fatty liver (steatosis), nonalcoholic steatohepatitis (NASH), and cirrhosis (advanced scarring of the liver) and methods for ameliorating and / or treating such disease conditions.

[0020]The formulation comprises compound of formula (I) and the method comprises administering to a subject in need thereof an effective amount of a compound according to Formula (I), or a pharmaceutically acceptable salt thereof.

wherein ‘R’ is selected from hydroxy, hydroxyalkyl, acyl, alkoxy, alkylthio, thioalkyl, aryloxy, arylthio and M+ represents suitable metal cations such as Na+, K+, Ca+2, Mg+2 and the like.

DEFINITIONS AND ABBREVIATIONS

[0021]As used above, and throughout this disclosure, the following terms, unle...

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Abstract

The present invention provides a compound of Formula (I) or pharmaceutical acceptable thereof, wherein ‘R’ is herein described. In addition, the invention relates to composition comprising effective therapeutic amount of compound of formula (I) and methods of using the compounds for treating or prevention disorder such as nonalcoholic fatty liver disease (NAFLD) including fatty liver (steatosis), nonalcoholic steatohepatitis (NASH), and cirrhosis (advanced scarring of the liver).

Description

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Claims

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Application Information

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Owner CADILA HEALTHCARE LTD
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