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A kind of detection method for musculoskeletal injury spray

A detection method and a spray technology, which are applied in the field of pharmaceutical inventions, can solve the problem of not being able to fully control the quality of Epimedium in products, the menthol content, the quality of Epimedium, the menthol content, and the quality of Epimedium. The problem of qualitative and quantitative detection is not carried out, so as to improve the separation degree and stability, shorten the detection time and save the detection cost

Active Publication Date: 2022-07-05
贵州远程制药有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The quantitative index in the current quality standard is paeoniflorin in Radix Paeoniae Rubra, and Chishan Powder is identified by TLC. No qualitative or quantitative detection is carried out for Epimedium, nor is menthol and Chishan Powder identified. Quantitative detection, so the standard is relatively simple and cannot effectively detect product quality
[0005] The company has done a lot of research on the detection method of Jingushang Spray, such as: developed a method for the simultaneous determination of paeoniflorin, icariin, ellagic acid, epimedin A, The content determination method of Huodin B, Epimedin C and Baohuoside I, the method is convenient to operate, strong in specificity, good in separation, high in stability, high in efficiency and can simultaneously treat seven active ingredients in the muscle and bone injury spray The advantages of content determination, but this technology has the following problems: ① The epimedium in the product has not been qualitatively identified and menthol has not been quantitatively detected, so the quality of epimedium and menthol in the product cannot be fully controlled. ②The main component of Epimedium in the product is icariin, and the main component of Chishan Powder is ellagic acid. The existing detection method is to simultaneously measure 7 components in the product. There is no targeted detection method for ellagic acid in icariin and Chishan powder, and the detection time is longer, and the separation and stability need to be further improved
[0006] Therefore, in order to solve the problem of not being able to fully control the quality of epimedium and the content of menthol in the product in the prior art, further improve the separation and stability of the content detection method, shorten the detection time, save detection costs, and thus comprehensively and effectively detect Product quality situation and control of product quality

Method used

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  • A kind of detection method for musculoskeletal injury spray
  • A kind of detection method for musculoskeletal injury spray
  • A kind of detection method for musculoskeletal injury spray

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Detection method of muscle and bone injury spray

[0073] [Prescription] Chishan powder 100g, red peony 30g, epimedium 50g, earthworm 10g

[0074] 2g Cauliflower 20g Menthol

[0075] [Preparation method] The above six flavors, except menthol, are crushed into coarse powder, mixed, placed in a container, added with 55% ethanol, sealed, soaked for 10 days, take the extract, stand, and filter. Menthol is dissolved in ethanol, added to the filtrate, and ethanol is added to adjust the alcohol content to 45% to 55% to 1000ml, and the mixture is evenly mixed.

[0076] 【Identification】

[0077] Take muscle and bone injury spray solution as the test solution, take another 0.3g of Epimedium control medicinal material, add 8ml of ethanol, warm soak for 25min, filter, evaporate the filtrate to dryness, add 1ml of ethanol to dissolve the residue, centrifuge, and take the supernatant as Control medicinal material solution, and then take an appropriate amount of icariin reference s...

Embodiment 2

[0099] Detection method of muscle and bone injury spray

[0100] [Prescription] Chishan powder 100g, red peony 30g, epimedium 50g, earthworm 10g

[0101] 2g Cauliflower 20g Menthol

[0102] [Preparation method] The above six flavors, except menthol, are crushed into coarse powder, mixed, placed in a container, added with 55% ethanol, sealed, soaked for 10 days, take the extract, stand, and filter. Menthol is dissolved in ethanol, added to the filtrate, and ethanol is added to adjust the alcohol content to 45% to 55% to 1000ml, and the mixture is evenly mixed.

[0103] 【Identification】

[0104] Take muscle and bone injury spray solution as the test solution, take another 0.3 g of Epimedium control medicinal material, add 8 ml of ethanol, warm soak for 25 min, filter, evaporate the filtrate to dryness, add 1 ml of ethanol to dissolve the residue, centrifuge, and take the supernatant as Control medicinal material solution, then take an appropriate amount of icariin reference s...

Embodiment 3

[0126] Detection method of muscle and bone injury spray

[0127] [Prescription] Chishan powder 100g, red peony 30g, epimedium 50g, earthworm 10g

[0128] 2g Cauliflower 20g Menthol

[0129] [Preparation method] The above six flavors, except menthol, are crushed into coarse powder, mixed, placed in a container, added with 55% ethanol, sealed, soaked for 10 days, take the extract, stand, and filter. Menthol is dissolved in ethanol, added to the filtrate, and ethanol is added to adjust the alcohol content to 45% to 55% to 1000ml, and the mixture is evenly mixed.

[0130] [Identification] Take the solution of tendon and bone injury spray as the test solution, and another 0.5g of Epimedium control medicinal material, add 10ml of ethanol, warm soak for 30min, filter, evaporate the filtrate to dryness, add 1ml of ethanol to dissolve the residue, centrifuge, and take the The serum was used as the control medicinal material solution. Then take an appropriate amount of icariin refere...

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Abstract

The invention relates to a detection method for a spray for tendon and bone injury, which is used for qualitative identification of icariin in the product, content determination of the icariin in the product by high performance liquid chromatography, and determination by gas chromatography. The content of menthol in the product is determined by high performance liquid chromatography; the method for qualitative and quantitative detection of Epimedium and the quantitative detection of menthol and Chishan powder are added in the present invention relative to the existing standard, and further The quality of the product is effectively controlled; the method of the present invention shows that the instrument precision and linear relationship are good, the specificity is strong, and the stability and repeatability are good.

Description

technical field [0001] The invention relates to the field of medical inventions, in particular to a detection method of a spray for musculoskeletal injuries. Background technique [0002] Soft tissue injury refers to the human skin, subcutaneous superficial and deep fascia, muscle, tendon, tendon sheath, ligament, joint capsule, synovial sac, intervertebral disc, peripheral nerve blood vessels and other tissues caused by various acute trauma or chronic strain, as well as their own disease and pathology. The pathological damage, called soft tissue injury, clinical manifestations: pain, swelling, deformity, dysfunction. [0003] Muscle and bone injury spray is developed and produced by Guizhou Yuanyuan Pharmaceutical Co., Ltd. It has the functions of promoting blood circulation and removing blood stasis, reducing swelling and relieving pain, and is mainly used for soft tissue injury. [0004] The quantitative index in the current quality standard is paeoniflorin in red peony ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
CPCG01N30/02G01N2030/025
Inventor 程吉祥刘青罗天军薛静伍朝平杨玉兰
Owner 贵州远程制药有限责任公司
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