A traditional Chinese medicine active ingredient composition with the effect of raising white blood cells

A technology for increasing leukocytes and active ingredients, applied in the field of traditional Chinese medicine active ingredient compositions for treating leukopenia, can solve the problems of increasing leukocytes, expensive side effects of new drugs, inaccurate treatment effects, etc. Good promotion value and remarkable curative effect

CN110327320BActive Publication Date: 2022-01-28SHANXI UNIV
5 Cites 1 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Publication Date
2022-01-28

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention belongs to the technical field of traditional Chinese medicine preparations. In order to solve the problems of inaccurate treatment effects of traditional medicines, high price of new medicines and obvious side effects in leukopenia medicine, a combination of active ingredients of traditional Chinese medicines with the effect of increasing white blood cells is provided. things. The active ingredient composition of traditional Chinese medicine with the effect of increasing white blood cells is composed of two or three kinds of ferulic acid in angelica, namely FA, ​​astragaloside IV in astragalus, AST, and atractylodes lactone I in Atractylodes macrocephala, i.e. AO-I. mixed. The present invention can significantly increase ( P <0.01) the white blood cell and bone marrow DNA content of the leukopenia animal model, indicating that the Chinese medicine active ingredient composition of the present invention has a significant curative effect in the treatment of leukopenia, and has good promotion value.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a traditional Chinese medicine active ingredient composition with the effect of increasing white blood cells, which is used for treating leukopenia. Background technique

[0002] Leukopenia refers to the continuous white blood cell count in peripheral blood <4.0×10 9 / L, is a common blood disease, often manifested as weakness, palpitations, dizziness, limp limbs, insomnia and dreaminess. When white blood cell count < 2.0×10 9 / L, the absolute value of neutrophils <0.5×10 9 / L, manifested as sudden headache, joint pain, extreme fatigue, etc., severe cases even have symptoms such as dysphagia, and the mortality rate is extremely high.

[0003] The main therapeutic chemical drugs for leukopenia include traditional drugs lithium carbonate and vitamin B4, and new drug colony-stimulating factors. However, the therapeutic effect...

Examples

Embodiment Construction

[0012] In order to make the objects and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the examples. The specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0013] ICR mice were weighed, numbered, and randomly divided into blank control group, model group, single-component experimental group, group combination experimental group and positive drug Lvjiao Buxue Granules group (LJG). On the 1st day of the experiment, the model was established. The mice in the model group were intraperitoneally injected with cyclophosphamide 80 mg / kg to establish the leukopenia model. The mice in the normal group were given an equal volume of sterilized water for injection for 3 consecutive days. The single-component experimental group, the combination experimental group and the LJG group were given corresponding drugs for 7 days on the basis of th...