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Application of red clover as haemophilus parasuis vaccine adjuvant

A technology of Haemophilus suis and red clover, which is applied in the field of application of red clover as an adjuvant for Haemophilus parasuis vaccine, can solve the problems of increasing difficulty and the influence of propolis adjuvant application and promotion, and achieve optimal addition amount and increase Immunity of the body and the effect of increasing antibody titer

Pending Publication Date: 2019-10-18
LONGYAN UNIV
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  • Abstract
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  • Application Information

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Problems solved by technology

This increases the difficulty for further research on its mechanism of action, and also affects the application and promotion of propolis adjuvant

Method used

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  • Application of red clover as haemophilus parasuis vaccine adjuvant
  • Application of red clover as haemophilus parasuis vaccine adjuvant
  • Application of red clover as haemophilus parasuis vaccine adjuvant

Examples

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Embodiment 1

[0016] Red clover extract was selected as an adjuvant to prepare red clover adjuvant vaccines containing different concentrations (multivalent seedlings + red clover high concentration, polyvalent seedlings + red clover medium concentration, polyvalent seedlings + red clover low concentration, multivalent seedlings + red clover low Concentration and blank control are shown in the following table 1), piglets were injected with 2 mL of multivalent inactivated vaccine containing adjuvant through the neck muscles at the age of 15 days, and the piglets in the test group were immunized for the second time 21 days after the first immunization, and the immunization route and dose were the same. After the first immunization and 14 days after the second immunization, the piglets in the test group were challenged with the serum types 4 and 5 of Haemophilus parasuis. 7.5×10 9 CFU, set up polyvalent vaccine and blank control at the same time (intraperitoneal injection of PBS in the control...

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Abstract

The invention discloses an application of a red clover as a haemophilus parasuis vaccine adjuvant. Bioactive substances obtained by extraction, separation and purification from Chinese medicinal herbsnamely red clover, mainly contain various components of flavonoid, amino acids, polysaccharide and the like, and the haemophilus parasuis vaccine adjuvant has the effects of resisting oxidation, preventing osteoporosis, resisting cancer, promoting animal growth and improving immunity of organisms. The haemophilus parasuis vaccine adjuvant is combined with a haemophilus parasuis multivalence inactivated vaccine, so that an aemophilus parasuis red clover adjuvant inactivated vaccine is prepared, and the additive amount of the red clover is optimized. After immunization twice, the antibody titerof aemophilus parasuis Hps can be effectively increased, and the IL-2 and IL-4 level of pigs can be effectively increased. The invention provides a novel vaccine and an immunization method for the haemophilus parasuis.

Description

technical field [0001] The invention relates to the technical field of veterinary biological products, in particular to the application of red clover as an adjuvant for Haemophilus parasuis vaccine. Background technique [0002] At present, traditional vaccines, such as Haemophilus parasuis vaccine, mostly use aluminum gel, mineral oil, and propolis as vaccine adjuvants. [0003] However, aluminum salts are not a good adjuvant in many situations, especially in inducing cellular immune responses. Granulomas are commonly produced when aluminum adjuvants are injected subcutaneously or intradermally rather than intramuscularly. Another side effect is increased IgE production, allergic reactions and possible neurotoxicity. Mineral oil adjuvants can produce a series of side effects due to the disadvantage of being unable to be metabolized, including inflammatory reactions at the injection site, granulomas, ulcers, and fever. In addition, mineral oil and its components such as p...

Claims

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Application Information

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IPC IPC(8): A61K39/39A61P31/04A61P37/04
CPCA61K39/39A61P31/04A61P37/04A61K2039/55588
Inventor 李晓华杨小燕邱龙新郑新添杨守深刘栋
Owner LONGYAN UNIV
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