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Use of carnosic acid and rosmarinic acid in joint preparation of medicine for preventing and treating type Ⅱ diabetic nephropathy

A technology for diabetic nephropathy and rosmarinic acid, applied in the field of medicine, can solve the problems such as the joint preparation of drugs for preventing and treating type II diabetic nephropathy with carnosic acid and rosmarinic acid.

Active Publication Date: 2020-12-11
CHINA PHARM UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, there is no report on the combination of carnosic acid and rosmarinic acid to prepare drugs for the prevention and treatment of type Ⅱ diabetic nephropathy

Method used

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  • Use of carnosic acid and rosmarinic acid in joint preparation of medicine for preventing and treating type Ⅱ diabetic nephropathy
  • Use of carnosic acid and rosmarinic acid in joint preparation of medicine for preventing and treating type Ⅱ diabetic nephropathy
  • Use of carnosic acid and rosmarinic acid in joint preparation of medicine for preventing and treating type Ⅱ diabetic nephropathy

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Embodiment Construction

[0018] The following describes the substantive content of the present invention in detail in conjunction with the drawings and embodiments, but does not limit the protection scope of the present invention.

[0019] 1. Experimental materials

[0020] The experimental animals were C57BL / 6 mice, male, 6-7 weeks old, purchased from Speifu Biological Co., Ltd. 60% high-fat feed (TP23400) and 10% low-fat control feed (TP23402) were purchased from Nantong Trophy Feed Technology Co., Ltd.

[0021] Streptozotocin (Sigma, USA); Citric acid (Ron Reagent Co., Ltd.); Sodium citrate, dihydrate (Ron Reagent Co., Ltd.); Sodium carboxymethylcellulose (Sinopharm Chemical Reagent Co., Ltd.) Carnosic acid (purity=98.76%, Chengdu Master Biotechnology Co., Ltd.); Rosmarinic acid (purity=97%, Shanghai Yuanye Biotechnology Co., Ltd.); Microalbumin (m-Alb) test box ( Nanjing Jiancheng Bioengineering Institute); Creatinine (Cr) Determination Kit (Nanjing Jiancheng Bioengineering Institute); Universal...

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Abstract

The invention discloses application of carnosic acid and rosemary acid to jointly prepare a drug for prevention and treatment of type II diabetes nephropathy. According to the application, it is foundthat the carnosic acid and the rosemary acid with the quality ratio of 6:1 can significantly and synergistically reduce fasting blood glucose of a type II diabetic nephropathy mouse, can significantly and synergistically decrease the urinary protein excretion rate and increase the urinary creatinine content and has significant and synergetic improvement effect on the kidney function of the diabetes nephropathy mouse, and the synergetic effect is unexpected by the technicians in the field.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the combined pharmaceutical use of known compounds, in particular to the combined use of carnosic acid and rosmarinic acid to prepare a medicine for preventing and treating type II diabetic nephropathy. Background technique [0002] Type Ⅱ diabetic nephropathy is the most serious and harmful chronic complication caused by type Ⅱ diabetes. etc. are the characteristics of this disease. The incidence of type Ⅱ diabetic nephropathy in my country is also on the rise, and it has become the second cause of end-stage renal disease, second only to various glomerulonephritis. Due to its complex metabolic disorders, once it develops into end-stage renal disease, it is often more difficult to treat than other kidney diseases. Therefore, timely prevention and treatment is of great significance for delaying type Ⅱ diabetic nephropathy. [0003] Carnosic acid was first found to exist in the Lamiaceae Sa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/216A61K31/192A61P3/10A61P13/12
CPCA61K31/192A61K31/216A61P3/10A61P13/12A61K2300/00
Inventor 李萍杨华田媛吴循循闻晓东
Owner CHINA PHARM UNIV
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