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Kit and applications of beta-glucan extract product in immunological enhancement of poultry animals

An animal immunization and immune enhancer technology, applied in the field of immunology, to achieve the effects of enhancing lymphocyte proliferation, increasing antibody production, and reducing morbidity or mortality

Pending Publication Date: 2019-11-12
LESAFFRE & CIE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Despite all these reports that β-glucans are able to induce strong immune responses and potentiate vaccine-induced immune responses, there is still no conclusive evidence for the use of β-glucans as vaccines in the vaccination of animals, especially birds Adjuvant

Method used

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  • Kit and applications of beta-glucan extract product in immunological enhancement of poultry animals
  • Kit and applications of beta-glucan extract product in immunological enhancement of poultry animals
  • Kit and applications of beta-glucan extract product in immunological enhancement of poultry animals

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0046] Material

[0047] SPF Chicken and Embryo : Purchase 580 21-day-old SPF chickens and 700 10-day-old chicken embryos from Beijing Vital Bridge Experimental Animal Co.Ltd.

[0048] feed : Purchasing from local commercial feed enterprises (what company, not found).

[0049] vaccine : Order Newcastle Disease Virus (NDV) and Infectious Bronchitis Virus (IBV) attenuated vaccines from Beijing Ceva-Huadou Biological Co.Ltd.

[0050] potion : Yeast glucan containing β-glucan is derived from Saccharomyces cerevisiae.

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Abstract

The invention relates to applications of a beta-glucan extract product in the immunological enhancement of poultry animals, and specifically provides a kit. The kit includes as follows: (1) an immune-enhancer used for enhancing the immunity of poultry animals and includes a beta-glucan extract product extracted from saccharomyces cerevisiae cell walls; and (2) a virus vaccine. Applications of thebeta-glucan extract product extracted from the saccharomyces cerevisiae cell walls in the preparation of the kit and immune-enhancer for enhancing the immunity of the poultry animals are also provided. Immunological enhancement can be performed on the poultry animals by using the beta-glucan extracted from the saccharomyces cerevisiae cell walls, so that lymphocyte proliferative response and T cell response of the poultry animals inoculated with the vaccine can be enhanced; viral load can be reduced; pathogenic rates or mortality can be lowered; antibodies can be generated in advance; antibodyproduction can be enhanced; and / or the diffusion of viruses can be restricted.

Description

technical field [0001] The invention relates to the field of immunology, in particular to the application of beta-glucan, a cell wall component of Saccharomyces cerevisiae, as an immune enhancer in poultry. Background technique [0002] One of the success stories of medicine right now is the development of vaccines against infectious viruses. However, vaccines are not always effective at inducing an immune response against a pathogen. Killed and subunit vaccines require adjuvants to enhance their immunogenicity. Alum (aluminum salt) is the most commonly used vaccine adjuvant in humans and animals. Alum has been considered safe for a century. However, neurotoxicity and local reactions of alum are problematic, especially when administered intradermally. Furthermore, alum induces a strong Th2-type (humoral) response and is effective against extracellular pathogens, but has little ability to induce a strong Th1 (cell-mediated) response, which is essential against many intrac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/39A61K39/17A61K39/215A61P31/14A61P37/04
CPCA61K39/39A61K39/12A61P37/04A61K2039/55583A61K2039/5252A61K2039/5254A61K2039/552A61K2039/53C12N2760/18134C12N2770/20034A61K2300/00A61K2039/55566A61K2039/55588A61P31/14A61K31/716A61K36/064A61K39/17A61K39/215
Inventor 何诚张天援T·K·格布利耀汉内斯
Owner LESAFFRE & CIE
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