Kit and applications of beta-glucan extract product in immunological enhancement of poultry animals

Abstract

The invention relates to applications of a beta-glucan extract product in the immunological enhancement of poultry animals, and specifically provides a kit. The kit includes as follows: (1) an immune-enhancer used for enhancing the immunity of poultry animals and includes a beta-glucan extract product extracted from saccharomyces cerevisiae cell walls; and (2) a virus vaccine. Applications of thebeta-glucan extract product extracted from the saccharomyces cerevisiae cell walls in the preparation of the kit and immune-enhancer for enhancing the immunity of the poultry animals are also provided. Immunological enhancement can be performed on the poultry animals by using the beta-glucan extracted from the saccharomyces cerevisiae cell walls, so that lymphocyte proliferative response and T cell response of the poultry animals inoculated with the vaccine can be enhanced; viral load can be reduced; pathogenic rates or mortality can be lowered; antibodies can be generated in advance; antibodyproduction can be enhanced; and / or the diffusion of viruses can be restricted.

Description

technical field [0001] The invention relates to the field of immunology, in particular to the application of beta-glucan, a cell wall component of Saccharomyces cerevisiae, as an immune enhancer in poultry. Background technique [0002] One of the success stories of medicine right now is the development of vaccines against infectious viruses. However, vaccines are not always effective at inducing an immune response against a pathogen. Killed and subunit vaccines require adjuvants to enhance their immunogenicity. Alum (aluminum salt) is the most commonly used vaccine adjuvant in humans and animals. Alum has been considered safe for a century. However, neurotoxicity and local reactions of alum are problematic, especially when administered intradermally. Furthermore, alum induces a strong Th2-type (humoral) response and is effective against extracellular pathogens, but has little ability to induce a strong Th1 (cell-mediated) response, which is essential against many intrac...

AI Technical Summary

Problems solved by technology

Despite all these reports that β-glucans are able to induce strong immune responses and potentiate vaccine-induced immune responses, there is still no conclusive evidence for the use of β-glucans as vaccines in the vaccination of animals, especially birds Adjuvant

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