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Anti-c5 antibodies and uses thereof

An antibody and variant technology, applied in the field of anti-C5 antibody and its application, can solve problems such as loss of epitope

Pending Publication Date: 2019-12-20
THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, not all PNH patients respond to eculizumab treatment, and one of the reasons for non-response is a genetic polymorphism in human C5, which loses the epitope that binds eculizumab

Method used

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  • Anti-c5 antibodies and uses thereof

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Embodiment 1

[0290] The complement system is a part of innate immunity that plays a key role in host defense. However, activated complement also has the potential to cause significant tissue damage and destruction, and dysregulated complement activity has been linked to rare and common disorders such as paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome , rheumatoid arthritis, and age-related macular degeneration. Therefore, anti-complement therapy is a promising approach for the treatment of these human conditions.

[0291] Complement C5 is a key protein in the terminal pathway of complement activation and is a precursor protein for the production of the potent pro-inflammatory mediator C5a as well as the lytic membrane attack complex (MAC).

[0292] Six murine anti-human C5 mAbs have been generated and characterized and confirmed to be function-blocking anti-human C5 mAbs that block activation of complement through the classical lectin or alternative pathway. ...

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Abstract

This invention relates to inhibition of the complement signaling using an C5 antibody. Specifically, the invention relates to methods of treating a complement- mediated disease or complement-mediateddisorder in an individual by contacting the individual with an anti-C5 antibody.

Description

[0001] References to related applications [0002] This application claims priority to U.S. Provisional Patent Application No. 62 / 467,498, filed March 6, 2017, the contents of which are incorporated herein by reference in their entirety. [0003] Statement Regarding Federally Sponsored Research or Development [0004] This invention was made with government support under NIH AI44970 awarded by the National Institutes of Health (NIH). The government has certain rights in this invention. Background technique [0005] The complement system is a part of innate immunity that plays a key role in host defense. However, activated complement also has the potential to cause significant tissue damage and destruction, and dysregulated complement activity has been associated with rare and common disorders such as paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremia syndrome, rheumatoid arthritis, age-related macular degeneration, etc. Therefore, anti-complement therapy ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395C07K16/00C07K16/18C07K16/28C07K16/46C12N15/09
CPCA61P37/00C07K16/18C12N15/09C07K2317/24C07K2317/528C07K2317/76C07K2317/92A61K2039/505C07K16/2896C07K2317/55C07K2317/565C07K2317/622
Inventor 宋文超佐藤纱也加三轮隆史达莫达尔·吉利帕利
Owner THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
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