Use of health-preserving anticancer tablet in preparation of anti-tumor and immunoregulation disease medicines

Abstract

The present invention provides a use of a health-preserving anticancer tablet in preparation of anti-tumor and immunoregulation diseases, and belongs to the technical field of use of traditional Chinese medicines. The related health-preserving anticancer tablet is prepared from a polysaccharide dry extractum extracted from a plurality of medicinal materials; and the medicinal materials comprise the following components: radix astragali, Chinese wolfberry fruits, cherokee rose fruits, rhizoma polygonati, semen cuscutae, glossy privet fruits, white peony roots, herba epimedii, liquorice and malt. The anti-tumor effect and the immunoregulation effect of the health-preserving anticancer tablet are researched through in-vivo anti-tumor tests and immunoregulation tests, demonstrating that the health-preserving anticancer tablet has a certain anti-tumor effect. At the same time, the health-preserving anticancer tablet can improve nonspecific immunity functions and provides a reference for further researches on the anti-tumor effect of subsequent traditional Chinese medicine compositions.

Description

technical field

[0001] The invention relates to the technical field of traditional Chinese medicine application, in particular to the application of a health-preserving and anti-cancer tablet in the preparation of anti-tumor and immunomodulatory disease drugs. Background technique

[0002] Tumor refers to the new organism formed by the proliferation of local tissue cells under the action of various tumorigenic factors. According to the cell characteristics of new organisms and the degree of harm to the body, tumors are divided into two categories: benign tumors and malignant tumors, and cancer is the general term for malignant tumors. At present, chemotherapy, radiotherapy and exosomal therapy are generally used as treatment methods for malignant tumors. Radiation therapy has large side effects and damages normal cells and cancer cells at the same time. Chemotherapy generally uses antibiotics, metabolic and hormonal drugs, etc. Great side effects. Therefore, an antitumor t...

Examples

preparation example Construction

[0032] The preparation process of the health-preserving and anti-cancer tablets is as follows:

[0033] Step 1) Take the medicinal materials, add 5-10 times the volume of water, and boil twice, each time for 1-2 hours;

[0034] Step 2) concentrating the extract obtained in step 1) under reduced pressure at 60-80°C to obtain a concentrated solution;

[0035] Step 3) Precipitate the obtained concentrated solution with 70% ethanol for more than 48 hours, purify the obtained precipitate with resin, and elute with 10% ethanol to obtain a health-preserving polysaccharide solution;

[0036] Step 4) The obtained health-preserving polysaccharide solution is concentrated to recover ethanol, and dried to obtain a health-preserving polysaccharide dry extract;

[0037] Step 5) The obtained health-preserving polysaccharide dry extract is pulverized, added with auxiliary materials, mixed evenly, granulated, and compressed into tablets to obtain health-preserving and anti-cancer tablets.

Embodiment

[0039] 1 Inhibitory effect on tumors in tumor-bearing mice:

[0040] Sixty-five female BALB / c nude mice aged 4 weeks were selected for the experiment. Inoculate 5×10 subcutaneously in the armpit of the right forelimb 6 cells / mL Skov3 ovarian cancer cells 0.2mL / only. Select 50 successful model mice, and randomly divide them into model control group, Yangsheng Kangai Tablet low, medium and high dose groups and cyclophosphamide group according to tumor volume, with 10 mice in each group. The model control group was given distilled water by intragastric administration, the low-, middle-, and high-dose groups of Yangsheng Kangcancer Tablets were given different doses (0.4, 0.8, 1.6g / kg) of Yangsheng Kangcancer Tablets by intragastric administration, and the cyclophosphamide group was dosed at 20 mg / kg. Cyclophosphamide was injected intraperitoneally, 1 time / d, for 2 consecutive weeks. The body weight of the mice was weighed the next day after the last administration, and the mic...

technical field

[0001] The invention relates to the technical field of traditional Chinese medicine application, in particular to the application of a health-preserving and anti-cancer tablet in the preparation of anti-tumor and immunomodulatory disease drugs. Background technique

[0002] Tumor refers to the new organism formed by the proliferation of local tissue cells under the action of various tumorigenic factors. According to the cell characteristics of new organisms and the degree of harm to the body, tumors are divided into two categories: benign tumors and malignant tumors, and cancer is the general term for malignant tumors. At present, chemotherapy, radiotherapy and exosomal therapy are generally used as treatment methods for malignant tumors. Radiation therapy has large side effects and damages normal cells and cancer cells at the same time. Chemotherapy generally uses antibiotics, metabolic and hormonal drugs, etc. Great side effects. Therefore, an antitumor t...

Examples

preparation example Construction

[0032] The preparation process of the health-preserving and anti-cancer tablets is as follows:

[0033] Step 1) Take the medicinal materials, add 5-10 times the volume of water, and boil twice, each time for 1-2 hours;

[0034] Step 2) concentrating the extract obtained in step 1) under reduced pressure at 60-80°C to obtain a concentrated solution;

[0035] Step 3) Precipitate the obtained concentrated solution with 70% ethanol for more than 48 hours, purify the obtained precipitate with resin, and elute with 10% ethanol to obtain a health-preserving polysaccharide solution;

[0036] Step 4) The obtained health-preserving polysaccharide solution is concentrated to recover ethanol, and dried to obtain a health-preserving polysaccharide dry extract;

[0037] Step 5) The obtained health-preserving polysaccharide dry extract is pulverized, added with auxiliary materials, mixed evenly, granulated, and compressed into tablets to obtain health-preserving and anti-cancer tablets.

Embodiment

[0039] 1 Inhibitory effect on tumors in tumor-bearing mice:

[0040] Sixty-five female BALB / c nude mice aged 4 weeks were selected for the experiment. Inoculate 5×10 subcutaneously in the armpit of the right forelimb 6 cells / mL Skov3 ovarian cancer cells 0.2mL / only. Select 50 successful model mice, and randomly divide them into model control group, Yangsheng Kangai Tablet low, medium and high dose groups and cyclophosphamide group according to tumor volume, with 10 mice in each group. The model control group was given distilled water by intragastric administration, the low-, middle-, and high-dose groups of Yangsheng Kangcancer Tablets were given different doses (0.4, 0.8, 1.6g / kg) of Yangsheng Kangcancer Tablets by intragastric administration, and the cyclophosphamide group was dosed at 20 mg / kg. Cyclophosphamide was injected intraperitoneally, 1 time / d, for 2 consecutive weeks. The body weight of the mice was weighed the next day after the last administration, and the mic...

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