Chinese medicine composition for treating nephropathy

A composition and technology of traditional Chinese medicine, applied to the traditional Chinese medicine composition for the treatment of chronic glomerular diseases, in the field of kidney disease, can solve the problems of poor drug stability, insignificant curative effect, rough preparation, etc., achieve no toxic side effects, good curative effect, group reasonable effect

Active Publication Date: 2008-12-03
BEIJING TONGRENTANG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There are many medicines used to treat nephropathy, such as: Shenyanling Capsules, Shenyan Xiaozhong Tablets, etc. In clinical application, these medicines have no significant curative effect, and the preparations are rough, the quality is not easy to control, and the drug stability is poor, so it can be seen Chinese patent medicines are still relatively blank in the treatment market for kidney diseases, especially chronic glomerular diseases. Therefore, the market urgently needs to develop a traditional Chinese medicine for kidney diseases with definite and significant curative effect, sophisticated technology and stable drug quality.

Method used

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  • Chinese medicine composition for treating nephropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0091] The prescription of the composition of the present invention:

[0092] Verbena 550, Mianzi 150, Salvia 280, Eclipta 200, Shiwei 180

[0093] Ligustrum lucidum 250, hawthorn 450, astragalus 300, arborvitae leaves 500

[0094] Preparation:

[0095] (1) adding 40%-95% ethanol to extract Danshen, Ligustrum lucidum and Radix Astragali to obtain alcohol extract;

[0096] (2) Extracting Verbena, Eclipta, Eclipta, Shiwei, Hawthorn and Arborvitae leaves with water to obtain water extracts;

[0097] (3) Filter the water extract of (2), concentrate under reduced pressure to a relative density of 1.05-1.25 (50°C), add ethanol to make the alcohol content reach more than 40% (preferably 60%), and filter to obtain the filtrate;

[0098] (4) the filtrate is combined with the ethanol extract obtained in (1) to obtain the medicinal extract;

[0099] (5) Preparation of granules: add dextrin and stevioside to the above-mentioned extract, mix thoroughly, make granules, and pack separate...

Embodiment 2

[0104] Prescription: Verbena 100, Scutellaria 100, Salvia 100, Eclipta 100, Shiwei 100

[0105] Ligustrum lucidum 100, hawthorn 100, astragalus 100, arborvitae leaves 100

[0106] (1) At least the above nine medicinal materials are separately or mixed and pulverized into fine powder to obtain the composition of the present invention.

[0107] (2) Mix the fine powder uniformly in step (1), add 40g of refined honey for every 100g of medicinal powder, and make honeyed water pills.

[0108] The result shows: the honeyed water pill of the composition of the present invention meets the relevant regulations under the honeyed water pill.

[0109] Qualitative and quantitative detection are the same as in Example 1.

[0110] This product contains astragaloside IV 0.10mg / g.

Embodiment 3

[0112] Prescription: Verbena 100, Mianzi 300, Salvia 100, Eclipta 100, Shiwei 200

[0113] Ligustrum lucidum 200, hawthorn 200, astragalus 300, arborvitae leaves 300

[0114] Preparation method: the preparation of the composition is the same as in Example 1;

[0115] Tablet: After mixing the extracts of the above-mentioned composition of the present invention, add binders such as dextrin, mix thoroughly, place at 60-80°C for vacuum drying, pulverize, add fillers such as starch, lubricants such as magnesium stearate, and Disintegrants such as sodium carboxymethylcellulose are mixed evenly, granulated, and compressed into tablets to obtain the tablet of the present invention.

[0116] The result shows: the composition tablet of the present invention meets relevant regulations under the tablet item.

[0117] Qualitative and quantitative detection are the same as in Example 1.

[0118] Astragaloside IV (C 41 h 68 o 14 ), not less than 0.20mg / tablet (0.5g / tablet).

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Abstract

The invention relates to a traditional Chinese medicine composition, a medicine containing the composition, a preparation method thereof, and an application of the medicine, wherein, the compositions of the composition are 0.3 to 3 portions of verbena officinalis, 0.1 to 3 portions of dioscorea septemloba, 0.3 to 3.3 portions of Salvia miltiorrhiza, 0.1 to 3 portions of herba ecliptae, 0.1 to 2 portions of pyrrosia leaf, 0.2 to 3 portions of fructus ligustri lucidi, 0.2 to 3 portions of hawthorns, 0.3 to 3 portions of astragalus roots and 0.3 to 3.5 portions of oriental arborvitae, and the compositions can come from traditional Chinese medicines or traditional Chinese medicine water extract equivalent to the crude medicine amount of the traditional Chinese medicines. The traditional Chinese medicine composition can be sued for treating nephrosis.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular, a traditional Chinese medicine composition for treating nephropathy, especially chronic glomerular disease, and the components of the composition can be Chinese medicinal materials that are directly crushed into powder and used as medicine And / or the extracted traditional Chinese medicine extract. Background technique [0002] Kidney diseases include conditions such as chronic glomerulonephritis and occult nephritis. Occult nephritis is a common clinical type of glomerulonephritis. Most of the patients have no obvious subjective symptoms. They only find protein or red blood cells in the urine during physical examination. Because they are often ignored, they cannot be treated in time and are delayed for a long time. Aggravated proteinuria and hematuria can also lead to renal damage. According to clinical observations, occult nephritis is more common in adolescents. Phy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61K9/08A61K9/10A61K9/06A61K9/14A61K9/16A61K9/20A61K9/48A61P13/12
Inventor 张绍来顾海鸥张维钧李向日李银刘柏刚王铭文张学著
Owner BEIJING TONGRENTANG CO LTD
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