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Use of health-care and anti-cancer tablets in the preparation of anti-tumor and immunomodulatory disease drugs

An immune regulation and anti-tumor technology, applied in the direction of anti-tumor drugs, drug combinations, allergic diseases, etc., can solve the problems of ineffective and slow effects, and achieve the effect of improving non-specific immune function

Active Publication Date: 2021-12-14
古汉中药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the existing methods of treating tumors with traditional Chinese medicine, there are generally deficiencies such as slow effect and inconspicuous effect. Therefore, we propose to improve the ingredients on the basis of the existing medicines and develop a new application, which can be used for anti-tumor and Immunomodulatory diseases, good curative effect

Method used

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  • Use of health-care and anti-cancer tablets in the preparation of anti-tumor and immunomodulatory disease drugs
  • Use of health-care and anti-cancer tablets in the preparation of anti-tumor and immunomodulatory disease drugs
  • Use of health-care and anti-cancer tablets in the preparation of anti-tumor and immunomodulatory disease drugs

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0032] The preparation process of the health-preserving and anti-cancer tablets is as follows:

[0033] Step 1) Take the medicinal materials, add 5-10 times the volume of water, and boil twice, each time for 1-2 hours;

[0034] Step 2) concentrating the extract obtained in step 1) under reduced pressure at 60-80°C to obtain a concentrated solution;

[0035] Step 3) Precipitate the obtained concentrated solution with 70% ethanol for more than 48 hours, purify the obtained precipitate with resin, and elute with 10% ethanol to obtain a health-preserving polysaccharide solution;

[0036] Step 4) The obtained health-preserving polysaccharide solution is concentrated to recover ethanol, and dried to obtain a health-preserving polysaccharide dry extract;

[0037] Step 5) The obtained health-preserving polysaccharide dry extract is pulverized, added with auxiliary materials, mixed evenly, granulated, and compressed into tablets to obtain health-preserving and anti-cancer tablets.

Embodiment

[0039] 1 Inhibitory effect on tumors in tumor-bearing mice:

[0040] Sixty-five female BALB / c nude mice aged 4 weeks were selected for the experiment. Inoculate 5×10 subcutaneously in the armpit of the right forelimb 6 cells / mL Skov3 ovarian cancer cells 0.2mL / only. Select 50 successful model mice, and randomly divide them into model control group, Yangsheng Kangai tablet low, medium and high dose groups and cyclophosphamide group according to tumor volume, with 10 mice in each group. The model control group was given distilled water by intragastric administration, the low-, medium-, and high-dose groups of Yangsheng Kangcancer Tablets were given different doses (0.4, 0.8, 1.6g / kg) of Yangsheng Kangcancer Tablets by intragastric administration, and the cyclophosphamide group was dosed at 20 mg / kg. Cyclophosphamide was injected intraperitoneally, 1 time / d, for 2 consecutive weeks. The body weight of the mice was weighed the next day after the last administration, and the mic...

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Abstract

The invention provides the use of a health-preserving and anti-cancer tablet in the preparation of anti-tumor and immunomodulatory disease medicines, which belongs to the technical field of traditional Chinese medicine applications. The health-preserving and anti-cancer tablets involved in the present invention are prepared from dry extracts of polysaccharides extracted from multi-flavor medicinal materials; Paeoniae Alba, Epimedium, Licorice, Malt. The present invention studies the anti-tumor effect and immunoregulatory effect of Yangsheng Anticancer Tablets through in vivo anti-tumor tests and immune regulation tests. The anti-tumor effect of traditional Chinese medicine composition is used for further research to provide reference.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine application, in particular to the application of a health-preserving and anti-cancer tablet in the preparation of anti-tumor and immunomodulatory disease drugs. Background technique [0002] Tumor refers to the new organism formed by the proliferation of local tissue cells under the action of various tumorigenic factors. According to the cell characteristics of new organisms and the degree of harm to the body, tumors are divided into two categories: benign tumors and malignant tumors, and cancer is the general term for malignant tumors. At present, chemotherapy, radiotherapy and exosomal therapy are generally used as treatment methods for malignant tumors. Radiation therapy has large side effects and damages normal cells and cancer cells at the same time. Chemotherapy generally uses antibiotics, metabolic and hormonal drugs, etc. Great side effects. Therefore, an antitumor t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/8998A61P35/00A61P37/04
CPCA61K36/481A61K36/815A61K36/738A61K36/8969A61K36/39A61K36/43A61K36/638A61K36/71A61K36/65A61K36/296A61K36/484A61K36/8998A61K9/20A61P35/00A61P37/04A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 钟源赵梦姣卢素云阳佑华谢康魏云
Owner 古汉中药有限公司
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