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Determination method of polyethylene glycol 4000 content in compound polyethylene glycol electrolyte powder

A polyethylene glycol and determination method technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problem of no obvious increase in the amount of feces, achieve the effect of small error, ensure clinical effect, and ensure quality

Pending Publication Date: 2020-01-10
重庆健能医药开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After oral administration, polyethylene glycol can fix water molecules through the hydrogen bond in the molecule, soften the stool and make it easy to pass, but the amount of stool does not increase significantly, and it is an osmotic laxative

Method used

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  • Determination method of polyethylene glycol 4000 content in compound polyethylene glycol electrolyte powder
  • Determination method of polyethylene glycol 4000 content in compound polyethylene glycol electrolyte powder
  • Determination method of polyethylene glycol 4000 content in compound polyethylene glycol electrolyte powder

Examples

Experimental program
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Effect test

Embodiment 1

[0014] 1. Main instruments and equipment

[0015] device name Device model Equipment manufacturers Electronic balance MS205DU Mettler Electronic balance AUW220D Shimadzu High performance liquid chromatography Agilent 1260 Agilent

[0016] 2. Sample information

[0017]

[0018] 2. Solution preparation

[0019] 2.1 Preparation of the test solution

[0020] Take an appropriate amount of compound polyethylene glycol electrolyte powder (containing about 400031 mg of polyethylene glycol), put it into a 50ml volumetric flask, dilute to the mark with water, and make a solution containing 40000.62 mg of polyethylene glycol per 1 ml.

[0021] 2.2 Preparation of reference solution

[0022] Weigh 15.5 mg of polyethylene glycol 4000 reference substance and put it in a 25 ml volumetric flask, add 1 ml of saline solution, and then dilute to the mark with water to make a solution containing 40000.62 mg of polyethylene glycol per 1 ml.

[00...

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Abstract

The invention provides a determination method of polyethylene glycol 4000 content in compound polyethylene glycol electrolyte powder. According to the method, a high-performance liquid chromatographicmethod and a differential refractive index detector are adopted, a hydrogel chromatographic column, namely a Plaquagel-OH column is used as the chromatographic column, an appropriate salty solution is selected to serve as a mobile phase, and an isocratic elution mode is adopted. The method is convenient and feasible to use, high in precision, accurate in detection result and good in repeatabilityand recovery rate; and through verification, the method can be used for detecting the polyethylene glycol 4000 content in the compound polyethylene glycol electrolyte powder.

Description

technical field [0001] The invention belongs to a method for detecting drug content, in particular to a method for determining the content of polyethylene glycol 4000 in compound polyethylene glycol electrolyte powder. Background technique [0002] Colonoscopy is currently an important means of diagnosing intestinal diseases and performing certain treatments, and high-quality bowel preparation is a prerequisite for the smooth progress of colonoscopy. [0003] The purpose of preoperative bowel preparation is to assist patients to expel accumulated feces and gas, empty the bowel, reduce intraoperative flatulence, facilitate the exposure of the surgical field, and avoid fecal contamination of the operating table due to anesthetic relaxation of the anal sphincter during surgery. An ideal bowel preparation method can not only make colon cleansing effect better, but also have high safety and easy acceptance by patients. [0004] Polyethylene glycol (PEG) is a long-chain polymer w...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/34G01N30/74
CPCG01N30/02G01N30/06G01N30/34G01N30/74
Inventor 周海燕唐检珍白晓红
Owner 重庆健能医药开发有限公司
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