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Preparation method of 2-aminobenzimidazole pseudo-template molecularly imprinted fluorescence sensing material and application thereof

A technology of aminobenzimidazole and template molecules, which is applied in the fields of luminescent materials, analytical materials, and material analysis through optical means, and can solve problems such as complicated pretreatment, high cost, and hazards

Active Publication Date: 2020-01-17
TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Heterocyclic amines have mutagenic activity and potential carcinogenicity, which will be produced during the thermal processing of food and cause harm to the human body
At present, the detection of heterocyclic amines mostly relies on large-scale tandem mass spectrometry equipment. This kind of method is complicated for sample pretreatment and takes a long time for analysis.
In addition, due to the wide variety of standard heterocyclic amines and the high cost, they cannot meet the demand for the amount of template molecules used in the synthesis of molecularly imprinted polymers; at the same time, in order to meet the requirements for highly pathogenic aminoimidazole nitrogen heterocyclic amine molecules ( AIAs) for simultaneous analysis and detection, so pseudo-template molecules similar in structure to such substances are selected for material synthesis, rapid development, good sensitivity, and high selectivity and high sensitivity for the detection of aminoimidazole nitrogen heterocyclic amine molecules (AIAs) The method provides a new idea for the detection of heterocyclic amines

Method used

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  • Preparation method of 2-aminobenzimidazole pseudo-template molecularly imprinted fluorescence sensing material and application thereof
  • Preparation method of 2-aminobenzimidazole pseudo-template molecularly imprinted fluorescence sensing material and application thereof
  • Preparation method of 2-aminobenzimidazole pseudo-template molecularly imprinted fluorescence sensing material and application thereof

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Embodiment 1

[0031] The present invention provides a preparation method and application of a CdSe / ZnS quantum dot-molecularly imprinted fluorescent sensing material for detecting aminoimidazole nitrogen heterocyclic amine molecules (AIAs). The specific preparation route is as follows:

[0032] (1) Preparation of CdSe / ZnS quantum dots-molecularly imprinted fluorescent sensing material of aminoimidazole nitrogen heterocyclic amine molecules (AIAs): 0.133g of pseudotemplate molecule 2-aminobenzimidazole, functional monomer 3-aminopropyl 941 μL of triethoxysilane (APTES), 100 μL of CdSe / ZnS quantum dots (oil-soluble, concentration of 8 μM), 1372 μL of tetraethoxysilane (TEOS) and 100 μL of ammonia water were dissolved in 10.0 mL of absolute ethanol, After degassing with nitrogen for 15 minutes, the polymerization was carried out for 24 hours under stirring at 600 rpm in the dark. Pseudo-template molecule 2-aminobenzimidazole: APTES: TEOS (molar ratio) = 1:4:6, that is, CdSe / ZnS quantum dot-mol...

Embodiment 2

[0035] The present invention provides a preparation method and application of a CdSe / ZnS quantum dot-molecularly imprinted fluorescent sensing material for detecting aminoimidazole nitrogen heterocyclic amine molecules (AIAs). The specific preparation route is as follows:

[0036] (1) Preparation of CdSe / ZnS quantum dots-molecularly imprinted fluorescent sensing material of aminoimidazole nitrogen heterocyclic amine molecules (AIAs): 0.133g of pseudotemplate molecule 2-aminobenzimidazole, functional monomer 3-aminopropyl APTES 941 μL, CdSe / ZnS quantum dots (oil-soluble, concentration 8 μM) 100 μL, cross-linking agent tetraethoxysilane (TEOS) 915 μL, ammonia water 100 μL were dissolved in 10.0 mL absolute ethanol, After degassing with nitrogen for 15 minutes, the polymerization was carried out for 24 hours under stirring at 600 rpm in the dark. Pseudo-template molecule 2-aminobenzimidazole: APTES: TEOS (molar ratio) = 1:4:4, that is, CdSe / ZnS quantum dot-molecularly imprinted f...

Embodiment 3

[0039] The present invention provides a preparation method and application of a CdSe / ZnS quantum dot-molecularly imprinted fluorescent sensing material for detecting aminoimidazole nitrogen heterocyclic amine molecules (AIAs). The specific preparation route is as follows:

[0040] (1) Preparation of CdSe / ZnS quantum dots-molecularly imprinted fluorescent sensing material of aminoimidazole nitrogen heterocyclic amine molecules (AIAs): 0.133g of pseudotemplate molecule 2-aminobenzimidazole, functional monomer 3-aminopropyl APTES 941 μL, CdSe / ZnS quantum dots (oil-soluble, concentration 8 μM) 100 μL, cross-linking agent tetraethoxysilane (TEOS) 1831 μL, ammonia water 100 μL were dissolved in 10.0 mL absolute ethanol, After degassing with nitrogen for 15 minutes, the polymerization was carried out for 24 hours under stirring at 600 rpm in the dark. Pseudo-template molecule 2-aminobenzimidazole: APTES: TEOS (molar ratio) = 1:4:8, that is, CdSe / ZnS quantum dot-molecularly imprinted ...

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Abstract

The invention discloses a preparation method of 2-aminobenzimidazole pseudo-template molecularly imprinted fluorescence sensing material, wherein that invention adopts a 2-aminobenzimidazole with a structure similar to that of amino-imidazoazaarenes (AIAs) as pseudo template molecule, CdSe / ZnS quantum dot is used as fluorescent probe, 3- Aminopropyltriethoxysilane is used as functional monomer, tetraethoxysilane is used as crosslinking agent, ammonia water is used as catalyst, anhydrous ethanol is used as solvent, and sol-gel method is used to synthesize molecularly imprinted polymer on the surface of quantum dots. Amino-imidazoazaarenes (AIAs) are detected by observing the fluorescence quenching of CdSe / ZnS quantum dots. The detection method of the invention is simple and convenient to operate, low in cost, high in accuracy and repeatability, and can detect amino-imidazoazaarenes (AIAs) in food with high selection and sensitivity.

Description

technical field [0001] The invention belongs to the technical field of optical sensing materials and molecular imprinting, and in particular relates to a preparation method and application of a 2-aminobenzimidazole pseudo-template molecular imprinting fluorescent sensing material. Background technique [0002] Heterocyclic amines (Heterocyclic Aromatic Amines, HAAs) are a class of aromatic compounds composed of carbon, nitrogen, and hydrogen atoms with a polycyclic structure. Most heterocyclic amines contain more than two aromatic rings, with at least One N atom, one -NH is connected outside the ring 2 , according to their formation mechanism can be divided into aminoimidazole nitrogen heterocyclic amine molecules (AIAs) and aminocarboline heterocyclic amine molecules (ACS). AIAs formed at 100-300°C are formed by complex Maillard reactions of precursors such as free amino acids, creatine and hexose, mainly including IQ, IQx, MeIQ, MeIQx, 4,8-DiMeIQx, PhIP, etc., will be pr...

Claims

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Application Information

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IPC IPC(8): C09K11/88C09K11/02C08G77/26C08J9/26C08L83/04G01N21/64
CPCC09K11/883C09K11/02C08G77/26C08J9/26G01N21/6428G01N21/6402C08J2201/0424C08J2383/04G01N2021/6432
Inventor 王硕乔丹邓启良
Owner TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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