Preparation method of injectable L-polylactide particles

A technology of L-polylactic acid and microparticles, which is applied in the field of medical cosmetic materials, can solve the problems of severe inflammatory response, poor dispersion effect, and long duration, and achieve good reconstitution and dispersion, good application effect, reduction degree and duration Effect

Active Publication Date: 2020-01-24
普丽妍(南京)医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Purpose of the invention: In view of the problems that the L-polylactic acid particles prepared by the existing method are all microspheres, the dispersion effect is not good, and the inflammatory reaction in the body after the degradation of the microspheres is severe and the duration is long, the present invention provides an injectable poly-L-lactic acid particle The preparation method, the method can be prepared to obtain sheet-like L-polylactic acid microparticles

Method used

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  • Preparation method of injectable L-polylactide particles
  • Preparation method of injectable L-polylactide particles
  • Preparation method of injectable L-polylactide particles

Examples

Experimental program
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Effect test

Embodiment 1

[0018] Disperse L-polylactic acid microspheres with an intrinsic viscosity of 3.8g / dL and a particle size of 60 microns in a mixed aqueous solution of sodium carboxymethylcellulose and mannitol, freeze-dry, heat the sample to 90 degrees, and apply 8 kg / cm2 pressure, after holding the pressure for 4 hours, the compressed sample was dissolved in water to form a solution, and after freeze-drying, injectable L-lactic acid microparticles could be obtained, the SEM image of which is as follows figure 1 , it can be seen that the resulting product is in the form of thin flakes.

Embodiment 2

[0024] Disperse L-polylactic acid microspheres with an intrinsic viscosity of 2.0g / dL and a particle size of 100 microns in a mixed aqueous solution of sodium carboxymethylcellulose and mannitol, freeze-dry, heat the sample to 60 degrees, and apply 1 kg / cm2 pressure, after holding the pressure for 0.5 hours, the compressed sample was dissolved in water to make a solution, and after freeze-drying, injectable L-lactic acid microparticles could be obtained, and its surface morphology was similar to that in Example 1. Also in thin flake form.

Embodiment 3

[0026] Disperse L-polylactic acid microspheres with an intrinsic viscosity of 5.0 g / dL and a particle size of 10 microns in a mixed aqueous solution of sodium carboxymethyl cellulose and mannitol. After freeze-drying, heat the sample to 100 degrees and apply 10 kg / cm2 pressure, after holding the pressure for 5 hours, the compressed sample is dissolved in water to make a solution, and after freeze-drying, injectable L-lactic acid particles can be obtained. Appearance is similar to that in Example 1.

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Abstract

The invention discloses a preparation method of injectable L-polylactide particles, including the following steps: (1) (1) dispersing L-polylactide microspheres into a mixed aqueous solution of carboxymethyl cellulose and mannitol, and freeze-drying; and (2) compressing the free-dried sample, dissolving the compressed sample in water to prepare a solution, and freeze-drying again to obtain flaky injectable L-polylactide particles. The prepared L-polylactide particles exist in the form of flaky particles, which is more beneficial to dispersion in a viscous solution in comparison with existing L-polylactide particles. Thereby, the application effect of the injectable L-polylactide particles of the invention is better. In addition, the method of the invention requires no use of organic solvents, so that the preparation process is green and environmentally-friendly in comparison with a conventional emulsification method. Moreover, the method of the invention has simple process, has advantages of high product preparation efficiency and high output in comparison with existing emulsification methods, and is suitable for large-scale industrial preparation.

Description

technical field [0001] The invention relates to a preparation method of injectable L-lactic acid microparticles, belonging to the field of medical cosmetic materials. Background technique [0002] Poly-L-lactic acid has good biocompatibility and degradation performance, and has been widely used in absorbable medical devices, tissue engineering, drug controlled release and medical cosmetic products. Injectable L-polylactic acid microspheres can be used as a cosmetic product. After being injected into the body, it can stimulate cells to produce a large amount of extracellular matrix, which plays a role in beauty and wrinkle removal (Clinics in Dermatology 2009, 27, S3-S12; Dermatol Surg 2005, 31, 1511-1518). [0003] The micronization of L-lactic acid is usually prepared into microspheres by emulsification method, and it is kept in a stable dispersion state in water by adding surfactants such as PVA, sodium dodecylsulfonate, Tween, and Span. Chinese invention patent (publica...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61L27/18A61L27/58A61L27/50
CPCA61L27/18A61L27/58A61L27/50A61L2400/06C08L67/04
Inventor何斌赵楠蒲雨吉朱虹成磊张译心
Owner普丽妍(南京)医疗科技有限公司