Blood purification through alkalifying agent

A technology of alkalizing agent and inhibitor, which is applied in blood diseases, applications, pill delivery, etc., and can solve the problems of no report, no report of decreased blood concentration of uremic substances, etc.

Pending Publication Date: 2020-02-14
TOHOKU UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] However, there is no report on the suppression of the development of renal damage by administration of alkalinizing agents to early CKD patients, and there is no report on the decrease in the blood concentration of uremic substances

Method used

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Examples

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Effect test

Embodiment

[0604] A human clinical trial was carried out to investigate whether oral administration of a potassium citrate-sodium citrate hydrate complex preparation and a sodium bicarbonate preparation as an oral alkalizing agent promotes urinary excretion of uremic substances.

[0605] 1. Method

[0606] Patients with chronic kidney disease (eGFR: 30-89ml / min / 1.73m 2 ) 47 were randomly divided into potassium citrate·sodium citrate hydrate compound preparation group (group A: 16 people), baking soda (sodium bicarbonate) preparation group (group B: 16 people) and control group (group C Group: 15 people). In each group, patients were classified by age, gender, presence or absence of diabetes, and eGFR without bias. Each group was treated based on "CKD Guidelines for Diagnosis and Treatment - Outline of Treatment" (hereinafter referred to as standard treatment).

[0607] For the control group, no alkalizing agent was administered. For group A, will contain potassium citrate (C 6 h 5 ...

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Abstract

The present invention relates to a food composition containing an alkalifying agent, in particular an alkali metal salt of citric acid. Renal function is maintained through ingestion of this food composition.

Description

technical field [0001] The present invention relates to a blood purification using an alkalizing agent. [0002] This application is based on Japanese Patent Application No. 2017-82423 filed in Japan on April 18, 2017, Japanese Patent Application No. 2017-85741 filed in Japan on April 24, 2017, and filed in Japan on May 25, 2017 Priority is claimed from Japanese Patent Application No. 2017-103935 filed on September 12, 2017 as an international application and application PCT / JP2017 / 032931, the contents of which are incorporated herein by reference. Background technique [0003] End-stage kidney failure (end-stage kidney disease: ESKD) patients requiring dialysis and transplantation are increasing in the world. There is also an increasing trend in Japan, and the number of dialysis patients reached 320,000 at the end of 2014. [0004] It is chronic kidney disease (CKD) considered to be a candidate of this ESKD. CKD is a concept that includes chronically progressive kidney d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A23L33/10A61K9/20A61K31/194A61P9/00A61P9/10A61P13/12A61P19/06
CPCA61K31/194A61P9/00A61P9/10A61P13/12A61P19/06A61P43/00A61P7/00A23L33/135A23L33/30A61K2300/00A61K33/00A61K31/19
Inventor 阿部伦明小柴生造西冈浩一郎川口和彦山崎里美寺中康行
Owner TOHOKU UNIV
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