Application of compound ad-35 in the treatment of diseases related to gastrointestinal motility disorders
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- ZHEJIANG HISUN PHARMA CO LTD
- Publication Date
- 2022-04-05
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Abstract
Description
technical field
[0001] The invention relates to the field of medicine, in particular to compound AD-35 and its pharmaceutical composition which can be used to treat diseases related to gastrointestinal motility disorder. Background technique
[0002] Motility of the gastrointestinal tract is a complex, highly coordinated neuromuscular activity controlled by the autonomic nervous system, hormones, and higher central nervous systems. The clinical manifestations of gastrointestinal motility disorders are dyspepsia symptoms such as easy satiety, abdominal distension, nausea, and vomiting, and can cause gastric and esophageal reflux, leading to esophageal ulcers, and severe cases can be life-threatening. Drugs clinically used to promote gastrointestinal motility mainly include DA receptor antagonists such as domperidone, 5-HT4 receptor agonists such as mosapride, and motilin receptor agonists such as erythromycin. Although these drugs have a certain prokinetic effect, the low sy...