Traditional Chinese medicinal spray for treating plaster allergy and preparation method thereof

A technology for allergies and traditional Chinese medicine, which is applied in the field of traditional Chinese medicine for external use and its preparation, as well as the traditional Chinese medicine spray for treating plaster allergy and its preparation. It can solve the problems of rapid onset of plaster allergy, achieve the effect of suppressing skin itching, preventing damage, and simple formula

Inactive Publication Date: 2020-03-13
河南省正骨研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are broad-spectrum anti-allergic corticosteroids and external and internal antihistamines that can be used, the existing drugs are difficult to respond quickly to plaster allergies, quickly suppress unbearable skin itching, and eliminate allergies Symptoms relieve the suffering of patients, and the allergy to the plaster is a local skin allergy in addition. Therefore, it is necessary to develop a safe and quick-acting external drug for the treatment of plaster allergy

Method used

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  • Traditional Chinese medicinal spray for treating plaster allergy and preparation method thereof
  • Traditional Chinese medicinal spray for treating plaster allergy and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Composition and dosage of the medicinal raw materials constituting the spray of the present invention, by weight percentage: 70% of fresh hawthorn, 20% of green plum, 10% of tangerine peel; its adjuvant and addition, according to its total volume percentage of the pharmaceutical solution: glycerin 5%, water-soluble azone 0.5%.

[0055] The preparation method of described spray:

[0056] 1. Remove the pits and slices of fresh hawthorn and green plums, and chop the tangerine peel appropriately.

[0057] 2. Weigh the processed hawthorn, green plum and tangerine peel, soak them in 30%-40% ethanol solution for several hours, separate the extracts, concentrate under reduced pressure until there is no alcohol smell.

[0058] 3. Slowly inject the concentrate into the macroporous resin column.

[0059] 4. Elute the macroporous resin column with pure water until the effluent is clear.

[0060] 5. Elute the macroporous resin column with 10% ethanol and collect the eluate until ...

Embodiment 2

[0064] Composition and consumption of the medicinal raw materials of spray of the present invention, by weight percentage:

[0065] 50% of fresh hawthorn, 30% of green plum, 20% of tangerine peel; the auxiliary materials and their addition amount, based on their percentage of the total volume of the medicinal solution: 10% of glycerin, 1.5% of water-soluble azone.

[0066] The preparation method of described spray:

[0067] 1. Remove the pits and slices of fresh hawthorn and green plums, and chop the tangerine peel appropriately.

[0068] 2. Weigh the processed hawthorn, green plum and tangerine peel, soak them in 30%-40% ethanol solution for several hours, separate the extracts, concentrate under reduced pressure until there is no alcohol smell.

[0069] 3. Slowly inject the concentrate into the macroporous resin column.

[0070] 4. Elute the macroporous resin column with pure water until the effluent is clear.

[0071] 5. Elute the macroporous resin column with 10% ethano...

Embodiment 3

[0075] Composition and dosage of the medicinal raw materials constituting the spray of the present invention, by weight percentage: fresh hawthorn 60%, green plum 25%, tangerine peel 15%; its adjuvant and addition, according to its total volume percentage of the pharmaceutical solution: glycerin 7.5%, water-soluble azone 1.0%.

[0076] The preparation method of described spray:

[0077] 1. Remove the pits and slices of fresh hawthorn and green plums, and chop the tangerine peel appropriately.

[0078] 2. Weigh the processed hawthorn, green plum and tangerine peel, soak them in 30%-40% ethanol solution for several hours, separate the extracts, concentrate under reduced pressure until there is no alcohol smell.

[0079] 3. Slowly inject the concentrate into the macroporous resin column.

[0080] 4. Elute the macroporous resin column with pure water until the effluent is clear.

[0081] 5. Elute the macroporous resin column with 10% ethanol and collect the eluate until the pH ...

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Abstract

The invention discloses a traditional Chinese medicinal spray for treating plaster allergy and a preparation method thereof. The spray is composed of the following raw materials in percentages by weight: 50%-70% of fresh hawthorn, 20%-30% of green plum and 10%-20% of pericarpium citri reticulatae; and auxiliary materials comprise the following components in percentages by volume based on the totalvolume of a prepared medicinal solution: 5%-10% of glycerol and 0.5%-1.5% of water-soluble azone. The preparation method comprises the following steps: weighing the fresh hawthorn, the green plum andthe pericarpium citri reticulatae which are treated, carrying out soaking in an ethanol solution with a concentration of 30%-40% for a plurality of hours, taking a leaching solution, and carrying outconcentration under reduced pressure until alcohol smell is removed; and filling a concentrate into a macroporous resin column, carrying out elution with water to remove impurities, collecting eluateobtained through elution with 10% ethanol, concentrating the eluate to a certain volume, carrying out filtering, then adding the glycerol and the water-soluble azone, and carrying out uniform mixingunder stirring. Pharmacodynamic test results prove that the medicine provided by the invention has significant effect of resisting inflammatory and delayed hypersensitivity, and has an exact treatmenteffect on the plaster allergy.

Description

technical field [0001] The invention relates to a traditional Chinese medicine for external use and its preparation, mainly provides a traditional Chinese medicine spray for treating plaster allergy and a preparation method thereof, belonging to the field of traditional Chinese medicine and traditional Chinese medicine pharmacy. Background technique [0002] Plasters (including black plasters, white plasters, and rubber plasters) are commonly used external medicines in daily life. When pasted on the skin, they can reduce inflammation, relieve pain, activate blood circulation and remove stasis, dredge meridians and collaterals, resuscitate the bones, expel wind and cold, etc. effect. After the plaster is applied, local skin redness, pigmentation, and mild itching often occur. Some people have redness, swelling, and itching at the plastered area, resulting in burning and discomfort, unbearable itching, and severe rashes, blisters, and even skin irritation. Ulceration, these a...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61K9/12A61P37/08A61P17/04
CPCA61K9/0014A61K9/12A61K36/185A61K36/734A61K36/752A61K47/22A61K2236/333A61K2236/51A61K2236/55A61P17/04A61P37/08A61K2300/00
Inventor 陈宝龙刘安妮成彦罗亚鸽肖鹏孙瑞凌春莹
Owner 河南省正骨研究院
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