Chitosan cicatrix biological medical adhesive and preparation method thereof

A biomedical and chitosan technology, applied in the field of biomedical glue, can solve the problems of high cost of skin scars, unsatisfactory treatment effect, recurrence and regeneration, etc., and achieve good lubricating effect, good sliding performance, and the effect of reducing disease.

Inactive Publication Date: 2014-06-25
GUANGXI XINYE BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The methods currently used mainly include: oral drug therapy, drug injection therapy, laser therapy, etc. Oral drug therapy and drug injection therapy to remove skin scars will produce certain side effects and adverse reactions, such as headache, abdominal pain, nausea, vomiting, etc. Laser therapy The cost of removing skin scars is relatively expensive, and the treatment effect is not ideal
[0004] The above methods will cause pigmentation or depigmentation to varying degrees after treatment, and some will cause recurrence and regeneration.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] A kind of chitosan scar biomedical glue, every liter of chitosan scar biomedical glue is made up of following raw materials:

[0061] Modified Chitosan 5g

[0062] Glycerin 30ml

[0063] Mint 0.5g

[0064] Lactic acid 0.1 g

[0065] Ginger Extract 0.5g

[0066] Viscosity modifier 3g

[0067] Purified water balance.

[0068] The modified chitosan is chitosan hydrochloride with a degree of deacetylation of 70%.

[0069] The viscosity modifier is carbomer.

[0070] A preparation method of chitosan scar biomedical glue, it comprises the following preparation steps:

[0071] Step A, adding purified water to the viscosity modifier in the formula to fully swell it to obtain a swollen body for subsequent use;

[0072] Step B, the preparation of ginger extract;

[0073] Step C, taking the modified chitosan, glycerin, peppermint, lactic acid, viscosity modifier, ginger extract of formula quantity;

[0074] Step D, dissolving the modified chitosan and peppermint of the for...

Embodiment 2

[0079] A kind of chitosan scar biomedical glue, every liter of chitosan scar biomedical glue is made up of following raw materials:

[0080] Modified Chitosan 18g

[0081] Glycerin 40ml

[0082] Mint 2.0g

[0083] Lactic acid 5g

[0084] Ginger Extract 2.0g

[0085] Viscosity modifier 20g

[0086] Purified water balance.

[0087] The modified chitosan is chitosan hydrochloride with a degree of deacetylation of 95%.

[0088] The viscosity regulator is sodium carboxymethyl cellulose.

[0089] A preparation method of chitosan scar biomedical glue, it comprises the following preparation steps:

[0090] Step A, adding purified water to the viscosity modifier in the formula to fully swell it to obtain a swollen body for subsequent use;

[0091] Step B, the preparation of ginger extract;

[0092] Step C, taking the modified chitosan, glycerin, peppermint, lactic acid, viscosity modifier, ginger extract of formula quantity;

[0093] Step D, dissolving the modified chitosan a...

Embodiment 3

[0098] A kind of chitosan scar biomedical glue, every liter of chitosan scar biomedical glue is made up of following raw materials:

[0099] Modified Chitosan 25g

[0100] Glycerin 45ml

[0101] Mint 2.2g

[0102] Lactic acid 6g

[0103] Ginger Extract 2.3g

[0104] Viscosity modifier 10g

[0105] Purified water balance.

[0106] The modified chitosan is carboxymethyl chitosan with a carboxylation degree of 80%.

[0107] The viscosity regulator is a mixture of carbomer and sodium carboxymethyl cellulose with a weight ratio of 1:1.

[0108] A preparation method of chitosan scar biomedical glue, it comprises the following preparation steps:

[0109] Step A, adding purified water to the viscosity modifier in the formula to fully swell it to obtain a swollen body for subsequent use;

[0110] Step B, the preparation of ginger extract;

[0111] Step C, taking the modified chitosan, glycerin, peppermint, lactic acid, viscosity modifier, ginger extract of formula quantity;

...

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Abstract

The invention relates to the technical field of biological medical adhesives, and particularly relates to a chitosan cicatrix biological medical adhesive and a preparation method thereof. Each liter of the chitosan cicatrix biological medical adhesive comprises the following raw materials: 5-30 grams of modified chitosan, 30-50 milliliters of glycerol, 0.5-2.5 grams of herba menthae, 0.1-10 grams of lactic acid, 0.5-2.5 grams of ginger extracting solutions, 3-35 grams of viscosity regulating agents and the balance of purified water. The chitosan cicatrix biological medical adhesive disclosed by the invention is complementary in raw material, can effectively reduce the pruritus, relieve the pain, fade the cicatrix color, ensures that the cicatrix is gradually reduced in area and become smooth, is suitable for inhibiting, alleviating and restoring the cicatrice caused by reasons, such as various burns and scalds, traumata, scratches, operations and acne, accelerates the healing of a wound surface, restores the surface cracks of the cicatrice, inhibits the secretion of collagen inside keloid skin, reduces the pruritus, relieves the pain and fades the cicatrix color.

Description

technical field [0001] The invention relates to the technical field of biomedical glue, in particular to a chitosan scar biomedical glue and a preparation method thereof. Background technique [0002] Scar is a general term for the appearance and histopathological changes of normal skin tissue caused by various traumas, and it is an inevitable product in the process of human trauma repair. Broadly speaking, there is no wound healing without scar tissue. However, when the scar grows beyond a certain limit, various complications will occur, such as the destruction of the appearance and functional disturbance, etc., which will bring huge physical pain and mental pain to the patient, especially the scar left after burns, scalds, and severe trauma. . [0003] Domestic and foreign medical circles have carried out a large number of long-term experimental studies from human tissue to cell, molecular and gene levels in order to find a safe, safe and effective method that can shorte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/06A61K9/08A61P17/02A61P31/02A61K31/722A61K31/19
Inventor 梁奕福
Owner GUANGXI XINYE BIOLOGICAL TECH
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