A compound traditional Chinese medicine preparation for preventing and treating Alzheimer's disease and its preparation method

A technology for Alzheimer's disease and compound traditional Chinese medicine, applied in the field of medicine, can solve the problems of high price, cannot delay the development of the disease, etc., and achieve the effects of low price, small toxic and side effects, and alleviating neuroinflammation

Active Publication Date: 2021-11-23
SHENZHEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the drugs for the treatment of Alzheimer's disease are mainly acetylcholinesterase inhibitors, anti-immune inflammation, calcium ion antagonists, antioxidants and other drugs. Nimodipine, memantine hydrochloride, etc. These drugs can only temporarily relieve the cognitive decline of patients, but cannot delay the development of the disease. Moreover, some of the above drugs have serious adverse reactions such as liver and kidney toxicity, and some drugs are expensive. It is unbearable, so it is still necessary to develop new drugs with good curative effect, low toxicity and side effects, and affordable prices; It has become a research hotspot to formulate traditional Chinese medicine formulas with reasonable formulas and definite curative effects, and to prepare high-efficiency and low-toxicity traditional Chinese medicine compound preparations for the prevention and treatment of Alzheimer's disease through modern Chinese medicine extraction technology.

Method used

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  • A compound traditional Chinese medicine preparation for preventing and treating Alzheimer's disease and its preparation method
  • A compound traditional Chinese medicine preparation for preventing and treating Alzheimer's disease and its preparation method
  • A compound traditional Chinese medicine preparation for preventing and treating Alzheimer's disease and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] A compound traditional Chinese medicine preparation for preventing and treating Alzheimer's disease comprises:

[0052] Eucommia: 70g;

[0053] Cinnamon: 80g;

[0054] Eclipta: 80g;

[0055] Epimedium: 90g;

[0056] Danpi: 80g;

[0057] Habitat: 60g;

[0058] Ginseng: 50g;

[0059] Schisandra: 80g.

[0060] The preparation method of the compound Chinese medicinal preparation for preventing and treating Alzheimer's disease comprises steps:

[0061] (1) Eucommia ulmoides, cinnamon, eclipta, epimedium, paeonol, habitat, root ginseng, Schisandra chinensis are prepared in various parts by weight;

[0062] (2) Mix eucommia ulmoides, cinnamon and eclipta, pulverize to obtain mixture A, add methanol equivalent to 6 times the weight of the mixture, soak for 5 hours, extract by reflux for 6 hours, filter, and the obtained medicinal residues I and filtrate II are set aside;

[0063] (3) Add 2 times the weight of β-cyclodextrin to the filtrate II obtained in step (2), wrap ...

Embodiment 2

[0067] A compound traditional Chinese medicine preparation for preventing and treating Alzheimer's disease comprises:

[0068] Eucommia: 80g;

[0069] Cinnamon: 100g;

[0070] Eclipta: 100g;

[0071] Epimedium: 110g;

[0072] Danpi: 90g;

[0073] Habitat: 90g;

[0074] Ginseng: 100g;

[0075] Schisandra: 120g.

[0076] The preparation method of the compound Chinese medicinal preparation for preventing and treating Alzheimer's disease comprises steps:

[0077] (1) Eucommia ulmoides, cinnamon, eclipta, epimedium, paeonol, habitat, root ginseng, Schisandra chinensis are prepared in various parts by weight;

[0078] (2) Mix eucommia ulmoides, cinnamon, and Eclipta chinensis, pulverize to obtain mixture A, add methanol equivalent to 8 times the weight of the mixture, soak for 6 hours, extract by reflux for 7 hours, filter, and the obtained medicinal residues I and filtrate II are set aside;

[0079] (3) Add 4 times the weight of β-cyclodextrin to the filtrate II obtained in...

Embodiment 3

[0083] A compound traditional Chinese medicine preparation for preventing and treating Alzheimer's disease comprises:

[0084] Eucommia: 100g;

[0085] Cinnamon: 110g;

[0086] Eclipta: 110g;

[0087] Epimedium: 120g;

[0088] Danpi: 100g;

[0089] Habitat: 110g;

[0090] Ginseng: 120g;

[0091] Schisandra: 130g.

[0092] The preparation method of the compound Chinese medicinal preparation for preventing and treating Alzheimer's disease comprises steps:

[0093] (1) Eucommia ulmoides, cinnamon, eclipta, epimedium, paeonol, habitat, root ginseng, Schisandra chinensis are prepared in various parts by weight;

[0094] (2) Mix eucommia ulmoides, cinnamon and eclipta, pulverize to obtain mixture A, add methanol equivalent to 12 times the weight of the mixture, soak for 7 hours, extract by reflux for 8 hours, filter, and the obtained medicinal residues I and filtrate II are set aside;

[0095] (3) Add 5 times the weight of β-cyclodextrin to the filtrate II obtained in step (...

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Abstract

The invention discloses a compound Chinese medicine preparation for preventing and treating Alzheimer's disease and a preparation method thereof, wherein the compound Chinese medicine preparation comprises 50-250 parts by weight of Eucommia ulmoides, 60-180 parts of cinnamon, 60 parts by weight ‑250 parts of Eclipta, 70‑300 parts of Epimedium, 60‑200 parts of Danpi, 60‑180 parts of Shengdi, 50‑200 parts of Yuanshen and 80‑160 parts of Schisandra. The compound traditional Chinese medicine preparation for preventing and treating Alzheimer's disease provided by the invention can effectively invigorate the kidney and replenish qi, activate blood and detoxify, effectively reduce neuroinflammation, improve AD symptoms, and is applicable to the prevention and treatment of AD and related diseases. The compound traditional Chinese medicine preparation of the invention has good curative effect, less toxic and side effects, and low price, and is suitable for extensive clinical promotion.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a compound traditional Chinese medicine preparation for preventing and treating Alzheimer's disease and a preparation method thereof. Background technique [0002] Alzheimer's Disease (AD) is the most common neurodegenerative disease, and it is also the main cause of senile dementia so far. Among all dementia patients, up to 50% to 60% are AD. AD is the fourth leading cause of death in the elderly after heart disease, cancer, and stroke. Because the pathological mechanism of AD is very complicated, the etiology is not very clear at present, and there is also a lack of effective treatment measures. Therefore, actively studying the pathogenesis of AD and developing effective anti-AD drugs is one of the important tasks in the field of senile disease research. [0003] From the point of view of traditional Chinese medicine in my country, cognitive impairment and senile dementia belong to th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/808A61K47/69A61P25/28
CPCA61K36/28A61K36/296A61K36/46A61K36/54A61K36/57A61K36/65A61K36/71A61K36/79A61K36/804A61K36/808A61K2236/33A61K47/6951A61P25/28A61K2300/00
Inventor 吴海强李玥余熙谢亚洲欧阳娜贺震旦刘志刚吴序栎刘立忠
Owner SHENZHEN UNIV
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