Novel application of genipin and discloses application of genipin in preparation of drug for preventing and treating Tau protein abnormality

A protein and abnormal technology, applied in the field of application of genipin in the preparation of drugs related to the prevention and treatment of Tau protein abnormalities

Pending Publication Date: 2020-04-07
SHENZHEN UNIV
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problem that genipin needs to be further developed and utiliz

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Novel application of genipin and discloses application of genipin in preparation of drug for preventing and treating Tau protein abnormality
  • Novel application of genipin and discloses application of genipin in preparation of drug for preventing and treating Tau protein abnormality
  • Novel application of genipin and discloses application of genipin in preparation of drug for preventing and treating Tau protein abnormality

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0019] In order to fully understand the technical content of the present invention, the technical solutions of the present invention will be further introduced and illustrated below in conjunction with specific embodiments. The experimental operations not described in detail in the experiment are routine experimental operations well known to those skilled in the art.

[0020] 1. Experimental materials and reagents:

[0021] Genipin (chemical structural formula such as figure 1 Shown), heparin sodium, thioflavin T (ThT) were purchased from Sigma; high-glucose DMEM medium, F12-DMEM medium, opti-MEM medium, penicillin, streptomycin, and fetal bovine serum were purchased from Gibco; Tau, pS396-Tau, pS404-Tau, and CDK5 antibodies were purchased from Abcam Company; ECL luminescent liquid was purchased from Thermo Fisher Scientific Company, and other conventional chemical reagents were purchased from Sigma Company.

[0022] 2. Genipin inhibits heparin-induced Tau protein aggregatio...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to the technical field of medicines, particularly to novel application of genipin and discloses application of genipin in preparation of a drug for preventing and treating Tau protein abnormality. The application comprises application in preparation of a Tau protein oligomerization inhibitor, application in preparation of a Tau protein fibrosis inhibitor, application in preparation of a Tau protein hyper-phosphorylation inhibitor and application in preparation of an anti-tauopathies drug. Experiments prove that genipin can effectively inhibit the formation of Tau proteinfibers induced by heparin; the combination mode of genipin and Tau protein fiber monomers is confirmed by utilizing computer molecular docking; the genipin can also reduce the phosphorylation level ofTau protein in the SH-SY5Y/Tau cells at the 396 and 404 sites of serine; the genipin inhibits the phosphorylation effect of Tau protein by reducing the activity of CDK5. In conclusion, genipin can beused for preparing medicines, functional foods and health-care products related to prevention and/or treatment of Tau protein abnormality.

Description

technical field [0001] The present invention relates to the field of pharmaceutical technology, in particular to the new application of genipin, the application of genipin in the preparation of drugs related to the prevention and treatment of Tau protein abnormalities, including the application in the preparation of Tau protein oligomerization inhibitors, The application in the preparation of Tau protein fibrosis inhibitors, the application in the preparation of Tau protein hyperphosphorylation inhibitors, and the application in the preparation of anti-Tau protein disease drugs. Background technique [0002] Tau protein is a microtubule-associated protein encoded by the MAPT gene on chromosome 17. It maintains normal axonal transport and microtubule structural stability under physiological conditions. Its basic function is to promote the assembly of tubulin into microtubules and further stabilize the existing Assembled microtubules. Under normal circumstances, two to three ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/352A61P25/28A61P25/00A23L33/00
CPCA61K31/352A61P25/28A61P25/00A23L33/00A23V2002/00A23V2200/322
Inventor 续旭蔡楠李梅婷顾粮杨朋姚丽君
Owner SHENZHEN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap