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Novel application of genipin and discloses application of genipin in preparation of drug for preventing and treating Tau protein abnormality

A protein and abnormal technology, applied in the field of application of genipin in the preparation of drugs related to the prevention and treatment of Tau protein abnormalities

Pending Publication Date: 2020-04-07
SHENZHEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Aiming at the problem that genipin needs to be further developed and utilized in the prior art, the present invention provides a new application about genipin

Method used

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  • Novel application of genipin and discloses application of genipin in preparation of drug for preventing and treating Tau protein abnormality
  • Novel application of genipin and discloses application of genipin in preparation of drug for preventing and treating Tau protein abnormality
  • Novel application of genipin and discloses application of genipin in preparation of drug for preventing and treating Tau protein abnormality

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Embodiment Construction

[0019] In order to fully understand the technical content of the present invention, the technical solutions of the present invention will be further introduced and illustrated below in conjunction with specific embodiments. The experimental operations not described in detail in the experiment are routine experimental operations well known to those skilled in the art.

[0020] 1. Experimental materials and reagents:

[0021] Genipin (chemical structural formula such as figure 1 Shown), heparin sodium, thioflavin T (ThT) were purchased from Sigma; high-glucose DMEM medium, F12-DMEM medium, opti-MEM medium, penicillin, streptomycin, and fetal bovine serum were purchased from Gibco; Tau, pS396-Tau, pS404-Tau, and CDK5 antibodies were purchased from Abcam Company; ECL luminescent liquid was purchased from Thermo Fisher Scientific Company, and other conventional chemical reagents were purchased from Sigma Company.

[0022] 2. Genipin inhibits heparin-induced Tau protein aggregatio...

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Abstract

The invention relates to the technical field of medicines, particularly to novel application of genipin and discloses application of genipin in preparation of a drug for preventing and treating Tau protein abnormality. The application comprises application in preparation of a Tau protein oligomerization inhibitor, application in preparation of a Tau protein fibrosis inhibitor, application in preparation of a Tau protein hyper-phosphorylation inhibitor and application in preparation of an anti-tauopathies drug. Experiments prove that genipin can effectively inhibit the formation of Tau proteinfibers induced by heparin; the combination mode of genipin and Tau protein fiber monomers is confirmed by utilizing computer molecular docking; the genipin can also reduce the phosphorylation level ofTau protein in the SH-SY5Y / Tau cells at the 396 and 404 sites of serine; the genipin inhibits the phosphorylation effect of Tau protein by reducing the activity of CDK5. In conclusion, genipin can beused for preparing medicines, functional foods and health-care products related to prevention and / or treatment of Tau protein abnormality.

Description

technical field [0001] The present invention relates to the field of pharmaceutical technology, in particular to the new application of genipin, the application of genipin in the preparation of drugs related to the prevention and treatment of Tau protein abnormalities, including the application in the preparation of Tau protein oligomerization inhibitors, The application in the preparation of Tau protein fibrosis inhibitors, the application in the preparation of Tau protein hyperphosphorylation inhibitors, and the application in the preparation of anti-Tau protein disease drugs. Background technique [0002] Tau protein is a microtubule-associated protein encoded by the MAPT gene on chromosome 17. It maintains normal axonal transport and microtubule structural stability under physiological conditions. Its basic function is to promote the assembly of tubulin into microtubules and further stabilize the existing Assembled microtubules. Under normal circumstances, two to three ...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P25/28A61P25/00A23L33/00
CPCA61K31/352A61P25/28A61P25/00A23L33/00A23V2002/00A23V2200/322
Inventor 续旭蔡楠李梅婷顾粮杨朋姚丽君
Owner SHENZHEN UNIV
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