Fluorescent microsphere co-doped with multiple near-infrared-II fluorescent dyes, preparation method and applications thereof
A technology of fluorescent dyes and fluorescent microspheres, which is applied in the direction of luminescent materials, analytical materials, material inspection products, etc., can solve the problems of reducing detection sensitivity and accuracy, fluorescence quenching, and reducing fluorescence intensity, so as to avoid fluorescence quenching, Good stability, increase the effect of fluorescence intensity
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Embodiment 1
[0073] Example 1: Preparation of fluorescent microspheres co-doped with two near-infrared II region fluorescent dyes
[0074] Two kinds of near-infrared II region fluorescent dyes are co-doped with fluorescent microspheres, including carboxypolystyrene spheres and two near-infrared II region fluorescent dyes embedded in the carboxypolystyrene spheres.
[0075] The particle size of the carboxylated polystyrene spheres is 300 nm.
[0076] The two near-infrared II region fluorescent dyes include Fluorochrome A and Fluorochrome B.
[0077] Fluorescent dye A, the structure is as follows:
[0078]
[0079] Fluorescent dye B, the structure is as follows:
[0080]
[0081] The specific preparation steps of co-doped fluorescent microspheres with two kinds of near-infrared II fluorescent dyes are as follows:
[0082] 1. Disperse 30mg of mixed fluorescent dye (fluorescent dye A: fluorescent dye B = 3:7, 4:6, 5:5, 6:4 or 7:3, W / W) in 10mL tetrahydrofuran solution to form organic ...
Embodiment 2
[0109] Example 2: Application of two kinds of near-infrared II region fluorescent dyes co-doped with fluorescent microspheres
[0110] Two kinds of near-infrared region II fluorescent dyes co-doped with fluorescent microspheres prepared in Example 1 were applied to immunochromatographic test strips to detect procalcitonin (PCT) in whole blood.
[0111] 1. Separate the detection antibody PCT-Ab 1 Fluorescent probes prepared by co-doping fluorescent microspheres with two near-infrared II region fluorescent dyes and embedding a near-infrared II region fluorescent dye fluorescent microspheres
[0112]1) Take 100 mg of fluorescent microspheres embedded with 30 mg of mixed fluorescent dye (fluorescent dye A: fluorescent dye B = 6:4, W / W) in Example 1, fluorescent microspheres embedded with 30 mg of fluorescent dye A in Comparative Example 1, and Comparative Example 1 Fluorescent microspheres embedded with 30 mg of fluorescent dye B were centrifuged, redissolved in 18 mL of BBS buff...
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