Method for targeting Hsp27 to inhibit enterovirus type A71 infection and related applications

A virus infection, EV-A71 technology, applied in the direction of antiviral agents, biochemical equipment and methods, pharmaceutical formulations, etc., can solve the problem of limited, promoting or limiting EV-A71 host factors have not been fully determined, host-virus interaction The underlying mechanism is complex and other issues
CN111110847AInactive Publication Date: 2020-05-08香港城市大学深圳研究院
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
香港城市大学深圳研究院
Publication Date
2020-05-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a method for targeting Hsp27 to inhibit enterovirus type A71 infection and related applications. Specifically, applications of Hsp27, as a target spot, to the developing, screening and / or preparing of drugs for controlling and / or inhibiting viral infection are also provided; and viruses are positive-strand RNA viruses containing IRES sequences, such as EV-A71, HCV or dengueviruses. A method for targeting small heat shock protein Hsp27 to inhibit enterovirus A71 infection is also provided.
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Description

technical field

[0001] The present invention relates to a new application of small heat shock protein Hsp27, specifically, the present invention relates to a method and related application of targeting Hsp27 to inhibit enterovirus A71 (EV-A71) infection. Background technique

[0002] Hand-foot-mouth disease (HFMD) is a global concern and is mainly caused by enterovirus A71 (EV-A71) and coxsackievirus A16 (CVA16). HFMD is usually a self-limiting disease with mild clinical manifestations, but in some cases, it can also lead to serious neurological complications and even death in children, especially those under 5 years of age. Complications include poliomyelitis-like acute flaccid paralysis, aseptic meningitis, brainstem encephalitis, and pulmonary edema.

[0003] EV-A71 was first isolated in California in 1969, and was identified as the pathogen causing hand, foot and mouth disease in Japan in 1973. In recent decades, sporadic occurrences or outbreaks of EV-A71 infection ha...

Claims

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