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Enterovirus Infections. Definition. Enteroviruses are so named because they reproduce initially in the gastrointestinal tract after infection occurs. Despite, this, they usually do not lead to intestinal symptoms; rather it is their spread to organs, such as the nervous system, heart, skin, and others that causes disease.
Human tryptophanyl-trna synthetase transgenic mouse models
The present disclosure relates to animal models that express human tryptophanyl-tRNA synthetase (hWARS) knock-in. These animal models are highly susceptible to enterovirus infection, including but not limited to EV-D68 and EV-A71 infection. Also disclosed are screening methods and compounds that utilize these animal models.
Owner:CENTRE FOR VIROLOGY VACCINOLOGY AND THERAPEUTICS LIMITED +1