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Application of ruscogenin in preparing blood sugar reduction medicine

A ruscogenin and hypoglycemic technology, which is applied in the application field of ruscogenin in the preparation of hypoglycemic drugs, can solve the problems of large side effects and limited practicability, and achieve small side effects, simple screening operation, The effect of convenience

Inactive Publication Date: 2020-05-19
XIAMEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the shortcomings of existing hypoglycemic drugs such as limited practicability and relatively large side effects, and to provide the application of ruscogenin in the preparation of hypoglycemic drugs, thereby providing a new antidiabetic drug in the treatment of diabetes candidate drug

Method used

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  • Application of ruscogenin in preparing blood sugar reduction medicine
  • Application of ruscogenin in preparing blood sugar reduction medicine
  • Application of ruscogenin in preparing blood sugar reduction medicine

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Embodiment Construction

[0031] In order to facilitate the understanding of the present invention, the following embodiments will further illustrate the present invention in conjunction with the accompanying drawings, so as to further explain the present invention, but do not limit the present invention in any way.

[0032] The application of ruscogenin in the preparation of hypoglycemic drugs, the structural formula of the ruscogenin (Ruscogenin) is:

[0033]

[0034] The specific screening method for the application of the ruscogenin in the preparation of hypoglycemic drugs is as follows:

[0035] (1) Feed the mice with high-fat diet for 12 weeks, and screen out the mice successfully induced into the hyperglycemia model through the glucose tolerance test;

[0036] (2) Divide the mice into groups and perfuse sodium carboxymethylcellulose, positive drugs rosiglitazone and ruscogenin respectively, and observe the change trend of blood sugar value through glucose tolerance test at 30 days and 45 days...

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Abstract

The invention discloses application of ruscogenin in preparing a blood sugar reduction medicine and relates to the technical field of natural medicines. Experiments show that ruscogenin has a remarkable blood sugar reduction function on a mouse suffering from hyperglycemia induced by high fat, is capable of remarkably reducing the level of blood sugar of a mouse suffering from diabetes, and has the main mechanism that utilization and conversion of glucose are intensified by promoting absorption of glucose in muscle tissue, so that formation of HbA1c can be interfered, and the blood sugar of the mouse suffering from hyperglycemia can be reduced. Therefore, the ruscogenin has good application prospects in preparing diabetes medicines and medicine compositions of the diabetes medicines. The ruscogenin is simple and convenient in extraction method, wide in source, small in side effect and wide in application. The whole screening operation is simple, the method is convenient and rapid, anda theoretic basis can be provided for further development of the ruscogenin in the field of diabetes.

Description

technical field [0001] The invention relates to the technical field of natural medicines, in particular to the application of ruscogenin in the preparation of hypoglycemic drugs. Background technique [0002] Diabetes is a group of clinical syndromes caused by the interaction of genetic and environmental factors, mainly type 1 and type 2. Type 1 diabetes is an autoimmune disease caused by the destruction of insulin-producing β-cells by the autoimmune system; Type 2 diabetes is mainly caused by insulin resistance and relative lack of insulin. Absolute or relative insufficiency of insulin secretion and decreased sensitivity of target tissues to insulin lead to metabolic disorders in the body, with hyperglycemia as the main common clinical sign. It has always been a research hotspot in the scientific field to find drugs that can lower the blood sugar level of the body in order to be used in the treatment of diabetes. [0003] Ruscogenin (Ruscogenin, RUS) is the main saponin a...

Claims

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Application Information

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IPC IPC(8): A61K31/58A61P3/10
CPCA61K31/58A61P3/10
Inventor 李明玉林春雨吴志强王冲范志昌
Owner XIAMEN UNIV
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