Traditional Chinese medicine particles capable of treating novel coronavirus (COVID-19) pneumonia, preparation method of traditional Chinese medicine particles capable of treating novel coronavirus pneumonia and transdermal patch capable of treating novel coronavirus pneumonia

A coronavirus, transdermal patch technology, applied in the field of biomedicine, can solve the problems of lack of effective control and treatment methods, and achieve the effect of avoiding the inconvenience of acupuncture, small size, and easy storage and use.

Inactive Publication Date: 2020-05-19
THE FIRST HOSPITAL OF CHINA MEDICIAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] As a newly discovered acute respiratory infectious...

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  • Traditional Chinese medicine particles capable of treating novel coronavirus (COVID-19) pneumonia, preparation method of traditional Chinese medicine particles capable of treating novel coronavirus pneumonia and transdermal patch capable of treating novel coronavirus pneumonia
  • Traditional Chinese medicine particles capable of treating novel coronavirus (COVID-19) pneumonia, preparation method of traditional Chinese medicine particles capable of treating novel coronavirus pneumonia and transdermal patch capable of treating novel coronavirus pneumonia
  • Traditional Chinese medicine particles capable of treating novel coronavirus (COVID-19) pneumonia, preparation method of traditional Chinese medicine particles capable of treating novel coronavirus pneumonia and transdermal patch capable of treating novel coronavirus pneumonia

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preparation example Construction

[0038] Aiming at the problem that there is currently no effective drug for the treatment of novel coronavirus pneumonia, the present invention provides a nano-Chinese medicine particle for the treatment of novel coronavirus pneumonia, a preparation method of the nano-Chinese medicine particle, a transdermal patch prepared by using the nano-Chinese medicine particle, and a transdermal patch. Preparation method and application of skin patch. The raw materials of nanometer traditional Chinese medicine granules are counted in parts by mass, including 3-3.5 parts of ephedra, 5-6 parts of rhubarb, 3 parts of trichosanthes, 3 parts of scutellaria, 1 part of white mustard seed, 1 part of asarum, 3 parts of atractylodes, and 3 parts of magnolia bark. 3-5 parts of ginger.

[0039]Each ingredient has the following effects: ephedra disperses lung pathogens to relieve asthma, rhubarb, melon, and scutellaria baicalensis clears lung heat, unblocks the internal organs, broadens the chest and ...

Embodiment 1

[0041] Embodiment 1, prepare a kind of Chinese medicine nano transdermal patch for the treatment of new coronary pneumonia

[0042] 1. Preparation of drug storage layer:

[0043] 1) Preparation of nanometer traditional Chinese medicine granules: each Chinese medicine component is weighed according to the prescription dose, after mixing, it is pulverized into 80 mesh coarse powder, and an appropriate amount of water is added to make a suspension, which is further refined by colloid mill mixing. The refinement solution is then placed in a homogenizer for nano-pulverization to make a nano-sized microemulsion with a particle size of 0.1-5 μm, which can be freeze-dried to obtain nano-Chinese medicine particles;

[0044] The raw materials of nanometer traditional Chinese medicine granules are counted in parts by mass, including 3 parts of ephedra, 6 parts of rhubarb, 3 parts of Trichosanthes, 3 parts of Scutellaria baicalensis, 1 part of white mustard seed, 1 part of asarum, 3 parts...

Embodiment 2

[0052] Example 2. The traditional Chinese medicine preparation was applied to the skin of mice for various experimental tests.

[0053] 1. Animal experiments

[0054] (1) Apply immunosuppressive nude mice, and establish a mouse model of lung inflammation with low immunity, apply the above-mentioned traditional Chinese medicine formula to the skin of nude mice for skin sticking treatment, observe the therapeutic effect, collect treatment samples, and observe the infiltration of inflammatory cells in the lungs of mice Impact.

[0055] The details are as follows: 6 nude mice were purchased and given intraperitoneal injection of LPS plus normal saline to simulate the clinical model of mouse lung inflammation. They were randomly divided into two groups, a control group and a treatment group, with 3 mice in each group. The treatment group was given traditional Chinese medicine sticking therapy, and the control group was given normal saline. One week later, the lung tissue of nude m...

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Abstract

The invention relates to the technical field of biological medicines, and specially provides traditional Chinese medicine particles capable of treating novel coronavirus (COVID-19) pneumonia, a preparation method of the traditional Chinese medicine particles capable of treating the novel coronavirus pneumonia and transdermal patch capable of treating the novel coronavirus pneumonia. The traditional Chinese medicine particles capable of treating the novel coronavirus pneumonia are traditional Chinese medicine nanoparticles composed of the following components in parts by mass: 3-3.5 parts of ephedra, 5-6 parts of rhubarb root and rhizome, 3 parts of snakegourd fruits, 3 parts of baical skullcap roots, 1 part of white mustard seeds, 1 part of manchurian wildginger, 3 parts of rhizome Chineseatractylodes, 3 parts of cortex magnoliae officinalis, and 3-5 parts of fresh ginger. The transdermal patch capable of treating the novel coronavirus pneumonia comprises a backing layer, a medicine storage layer, a medicine controlled release membrane layer, and an adhesive layer; and the medicine storage layer comprises gel matrix, and the traditional Chinese medicine nanoparticles. The transdermal patch adopts a transdermal absorption means of acupoint patch so as to achieve the effects of improving immunity of a patient and enhancing resistance of body immune cells to novel coronavirus infection.

Description

technical field [0001] The invention relates to the technical field of biomedicine, and in particular provides a traditional Chinese medicine granule for treating novel coronavirus pneumonia, a preparation method and a transdermal patch. Background technique [0002] As a newly discovered acute respiratory infectious disease, COVID-19 lacks effective control and treatment methods. It is urgent and reasonable to explore effective intervention strategies and treatment methods from traditional medicine. The clinical effect of traditional Chinese medicine in controlling similar public health emergencies such as SARS and H1N1 influenza is remarkable, and it has been preliminarily confirmed by modern human clinical research, which shows that the historical experience of traditional Chinese medicine treatment is worth learning. [0003] According to the comprehensive analysis of the TCM diagnosis and treatment guidelines issued by 23 provinces since the outbreak of COVID-19, as we...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/14A61K9/70A61K47/36A61P31/14A61P11/00
CPCA61K9/14A61K9/7023A61K36/17A61K36/268A61K36/284A61K36/31A61K36/428A61K36/539A61K36/575A61K36/708A61K36/9068A61K47/36A61P11/00A61P31/14A61K2300/00
Inventor 谷佳韩涛李京商磊李秋华刘然孙雷赵岩向代民左芷凡
Owner THE FIRST HOSPITAL OF CHINA MEDICIAL UNIV
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