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A kind of cetirizine hydrochloride tablet and preparation method thereof

A technology of cetirizine hydrochloride and lizine tablets, which is applied in the field of medicine and can solve problems such as complex processes

Active Publication Date: 2021-09-07
广东彼迪药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The base needs to be prepared first, and then processed by rotary evaporation, the process is more complicated

Method used

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  • A kind of cetirizine hydrochloride tablet and preparation method thereof
  • A kind of cetirizine hydrochloride tablet and preparation method thereof
  • A kind of cetirizine hydrochloride tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022]

[0023] Preparation Process:

[0024] Dissolve cetirizine hydrochloride and polyoxyl stearate in ethanol, add diatomaceous earth to the solution, stir evenly, and dry at 50°C to obtain a mixture, then sieve the mixture, and then mix with Silicified microcrystalline cellulose is mixed with sodium carboxymethyl starch and magnesium stearate, and compressed into tablets.

Embodiment 2

[0026]

[0027]

[0028] Preparation Process:

[0029] Dissolve cetirizine hydrochloride and polyoxyl stearate in ethanol, add diatomaceous earth to the solution, stir well, and dry at 55°C to obtain a mixture, then sieve the mixture, and then mix with Silicified microcrystalline cellulose mixed with crospovidone and magnesium stearate, and compressed into tablets.

Embodiment 3

[0031]

[0032] Preparation Process:

[0033] Dissolve cetirizine hydrochloride and polyoxyl stearate in ethanol, add diatomaceous earth to the solution, stir evenly, and dry at 60°C to obtain a mixture, then sieve the mixture, and then mix with Silicified microcrystalline cellulose is mixed with sodium carboxymethyl starch and magnesium stearate, and compressed into tablets.

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PUM

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Abstract

The invention discloses a cetirizine hydrochloride tablet, which is prepared by the following method: dissolving cetirizine hydrochloride and polybutylene oxide stearate in ethanol, adding diatomaceous earth into the solution, stirring evenly, The obtained mixture is dried, then mixed with silicified microcrystalline cellulose, disintegrant and lubricant, and compressed into tablets. The cetirizine hydrochloride tablet prepared by the method has rapid dissolution, no sticky punch, and no corrosion to the die.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a cetirizine hydrochloride tablet and a preparation method thereof. Background technique [0002] Cetirizine hydrochloride is a second-generation H1 antihistamine, a long-acting and selective oral potent antiallergic drug. H1 receptor antagonists have good anti-allergic effects, and are often used for allergic rhinitis, allergic skin itching, conjunctivitis, etc. Cetirizine hydrochloride sheet is a kind of medicine commonly used, and present cetirizine hydrochloride sheet has the shortcoming of unstable property, because cetirizine hydrochloride is an acidic drug, it is very easy to react chemically with other substances in the formula, The content prepared by the prior art is unstable, affects the dosage, has a short validity period, is not conducive to the transportation and storage of the product, and has potential safety problems. [0003] In addition, most of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K47/38A61K47/34A61K31/495A61P37/08A61P11/02A61P17/04A61P27/02
CPCA61K9/2031A61K9/2054A61K31/495A61P11/02A61P17/04A61P27/02A61P37/08
Inventor 司徒卫彤杨松明
Owner 广东彼迪药业有限公司
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