Magnesium-rich artificial cerebrospinal fluid, and preparation method and applications thereof

Abstract

The invention discloses magnesium-rich artificial cerebrospinal fluid, and a preparation method and applications thereof. Used raw materials are clinical intravenous medications, so that the raw materials are easy to obtain and low in price; the magnesium-rich artificial cerebrospinal fluid is simple in preparation technology, and complex sterilization processes are not needed; the magnesium-richartificial cerebrospinal fluid is time- and labor-saving in preparation and can be used while being prepared; and through animal experiments and small-scale clinical studies, the safety and effectiveness of the magnesium-rich artificial cerebrospinal fluid can be verified. In summary, obtained drugs have the advantages of being simple in preparation, economical, practical, safe and reliable; and new thoughts and directions can be provided for clinical work.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and relates to an artificial cerebrospinal fluid and a preparation method thereof, in particular to a magnesium-rich artificial cerebrospinal fluid, a preparation method and application thereof. Background technique [0002] Subarachnoid hemorrhage (SAH) is a common hemorrhagic stroke in neurology, with an annual incidence of about 9-20 / 100,000. Aneurysm rupture is the most common cause, namely aneurysmal subarachnoid hemorrhage ( aneurysmal subarachnoid hemorrhage, aSAH). Cerebral vasospasm (CVS) is one of the most common complications of aSAH, with an incidence rate as high as 30-90%, and it is the main cause of disability and death of patients. Studies have shown that even if aSAH patients can receive surgical treatment in time to temporarily pass the dangerous period, they may still have neurological deficits due to the occurrence of CVS. [0003] The high-incidence period of CVS after ...

AI Technical Summary

Problems solved by technology

These ACSFs are all prepared by chemical reagents, and the preparation process is complicated, so their clinical application is limited

At the same time, the existing reported medical ACSF, such as the Chinese patent with the patent publication number CN102018724A, shows that its formula clearly contains calcium salt components, and the concentrations of calcium ions and magnesium ions are relatively high, which is easy to cause precipitation and affect safety.

Moreover, the preparation method and disinfection and sterilization steps disclosed in this patent have very high requirements for equipment and workplaces, and preparation rooms must be needed to realize it. However, most hospitals currently do not have preparation rooms, so they cannot meet the standards. Therefore, it is more difficult to realize the promotion

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