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Contrast agent, and preparation method and application thereof

A technology of contrast agent and red blood cell, which is applied to MRI/magnetic resonance imaging contrast agent, fixed on or in an inorganic carrier, etc., can solve the problem that CMR cannot be used for clinical detection, etc., so as to improve the application effect and meet the production and application requirements. , the effect of long half-life

Inactive Publication Date: 2020-06-12
THE FOURTH AFFILIATED HOSPITAL OF ZHEJIANG UNIV SCHOOL OF MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, none of the above three methods can be used for clinical detection of CMR.

Method used

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  • Contrast agent, and preparation method and application thereof
  • Contrast agent, and preparation method and application thereof
  • Contrast agent, and preparation method and application thereof

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Embodiment Construction

[0042] Hereinafter, preferred embodiments of the present invention will be described in detail with reference to examples. In addition, the embodiments of the present invention are not limited to the following examples, and include various substitutions and modifications within the scope of the technical concept of the present invention.

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Abstract

The invention provides a contrast agent as well as a preparation method and application thereof. Erythrocyte in blood is used as a matrix, by loading the gadolinium chelate onto red blood cells by a hypotonic precipitation method, a novel electroporation method, a drug induction method and a drug induction method under a hypotonic condition, the gadolinium chelate has the advantages that the volume of the gadolinium chelate is increased, the migration of the gadolinium chelate to the outside of a blood vessel is blocked, the technical problem that an existing magnetic resonance contrast agentis easy to migrate to a gap outside the blood vessel is solved, and the contrast agent has wide application in the fields of magnetic resonance imaging and imaging.

Description

technical field [0001] The invention relates to a contrast agent, a preparation method of the contrast agent and an application thereof, and belongs to the field of medical contrast agents. Background technique [0002] In recent years, cardiac magnetic resonance imaging (CMR), as a non-invasive image analysis method, has been widely concerned and applied in the diagnosis of heart disease. By using CMR technology, the left and right ventricles of the heart, myocardial structure and blood flow in valve tissue can be clearly observed, which provides a powerful imaging basis for the detection and treatment of heart disease. In the clinical practice of CMR, in order to obtain high-definition images, it is often necessary to inject contrast agents to improve image contrast. Gadolinium chelate is the most widely used contrast agent at present, because gadolinium ions have the advantages of large magnetic moment and obvious T1 enhancement effect. However, gadolinium chelates are ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/08C12N11/14
CPCA61K49/08C12N11/14
Inventor 冯超夏淑东王可伍李亮李齐明
Owner THE FOURTH AFFILIATED HOSPITAL OF ZHEJIANG UNIV SCHOOL OF MEDICINE
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