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Alkaloid with anti-inflammatory activity in purslane as well as extraction and separation method and application thereof

A technology of active alkaloids and separation methods, which is applied in the field of extraction and separation of traditional Chinese medicines, can solve the problems of low structural novelty, and achieve the effects of environmentally friendly process methods, simple and fast operation methods, and significant anti-inflammatory activity

Active Publication Date: 2020-06-19
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, most of the chemical components isolated from purslane are known, and the structural novelty is low. Therefore, the development and isolation of new compounds in purslane are urgently needed

Method used

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  • Alkaloid with anti-inflammatory activity in purslane as well as extraction and separation method and application thereof
  • Alkaloid with anti-inflammatory activity in purslane as well as extraction and separation method and application thereof
  • Alkaloid with anti-inflammatory activity in purslane as well as extraction and separation method and application thereof

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Embodiment Construction

[0034] The present invention provides new compound, molecular formula is C 15 h 13 NO 5 , named Portulacatone A, the chemical structural formula is:

[0035]

[0036] Table 1 is the nuclear magnetic data of this new compound: 1 H-NMR with 13 C-NMR in DMSO

[0037] serial number δ C

type δ H (J in Hz)

1 117.4 CH 7.03d(4.3) 2 116.5 CH 6.90d(4.3) 3 125.0 C 5 46.7 CH 2

4.78m 6 34.3 CH 2

3.13m 6a 134.3 C 7 116.4 CH 6.64s 8 151.2 C *

9 144.5 C 10 117.2 CH 7.46s 10a 126.6 C *

11 179.7 C 11a 139.1 C C 3 -CO 2 Me

160.9 C C 3 -CO 2 Me

51.7 CH 3

3.80s

[0038] Portulacatone A: Pale yellow oil, easily soluble in methanol, insoluble in water. After spotting the sample on the silica gel thin-layer plate, the spots of the dilute potassium bismuth iodide test solution appear orange-red, suggesting that the c...

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Abstract

The invention relates to the field of traditional Chinese medicine extraction and separation, in particular to a new compound extracted, separated and identified from purslane and an extraction and separation method thereof. The molecular formula of the novel compound is C15H13NO5, and the novel compound is named as portulacatone A. The invention also provides an extraction and separation method of the new compound, and the new alkaloid compound is successfully extracted and separated by sequentially adopting alcohol extraction, silica gel column chromatography, polyamide column chromatography, ODS medium-pressure column and Sephadex LH-20 separation preparation. The structure of the alkaloid compound is identified as a new alkaloid compound by a mass spectrum, carbon spectrum, hydrogen spectrum and two-dimensional nuclear magnetic spectrum analysis method. The new compound has potential anti-inflammatory activity and the like, a preparation method is provided, and a primer and a theoretical basis are provided for developing new drugs.

Description

technical field [0001] The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to a new compound extracted, separated and identified from purslane medicinal material and an extraction and separation method thereof. Background technique [0002] Purslane (Portulaca oleracea L.), also known as longevity dish, horse amaranth, is a plant of the family Amaranthaceae. Purslane is drought and waterlogging resistant, light and shade resistant, widely distributed, and rich in resources. It has attracted much attention as a wild plant for both medicine and food. The 2015 edition of "Pharmacopia of the People's Republic of China" recorded the dry aerial parts of purslane as medicine. , has the functions of clearing away heat and detoxification, cooling blood to stop bleeding, and stopping dysentery. [0003] Modern pharmacological studies of purslane have shown that it has the functions of anti-inflammatory and analgesic, antibac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D487/04A61P29/00A61K31/55A61K8/49A61Q19/00A23L33/105
CPCC07D487/04A61P29/00A61K8/4906A61Q19/00A23L33/105A23V2002/00A23V2200/30A23V2250/21
Inventor 英锡相顾莹莹英哲铭
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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