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Preparation method for RuCu2O photo-thermal healing-promoting band-aid

A band-aid and photothermal technology, applied in the field of nanomedicine, can solve problems such as low efficiency

Inactive Publication Date: 2020-07-03
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although most metals have antibacterial properties, their efficiency is low, so metal photothermal sterilization is widely used

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Preparation method of RuCu2O photothermal healing band-aid:

[0019] 1) In a 50ml round bottom flask, add RuCl3·xH successively 2 O TEG solution (20mmol L-1) 1ml, PVP TEG solution (200mmol L-1) 2ml CTAB TEG solution (200mmol L-1) 0.1ml.

[0020] 2) Add an appropriate amount of TEG to make the total volume of the reaction solution 8mL. Stir thoroughly to obtain a wine red transparent liquid.

[0021] 3) Heating and stirring in an oil bath at 170°C for 24 hours, the color of the solution changed from wine red to dark green to light yellow, and finally a brown-black transparent colloidal solution was obtained.

[0022] 4) The prepared Ru colloidal solution was left without precipitation for a long time, and different Ru nanoparticles could be obtained by changing the amount of CTAB added. The Ru colloidal solution was treated with acetone to obtain Ru nanoparticles, which were redispersed with ethanol for later use.

[0023] 5) Then Ru colloid was added to the mixed solu...

Embodiment 2

[0026] Preparation method of RuCu2O photothermal healing band-aid:

[0027] 1) Add RuCl in turn to a 50ml round bottom flask 3 ·xH 2 O TEG solution (20mmol L-1) 1ml, PVP TEG solution (200mmol L-1) 2ml CTAB TEG solution (200mmol L-1) 0.1ml.

[0028] 2) Add an appropriate amount of TEG to make the total volume of the reaction solution 8mL. Stir thoroughly to obtain a wine red transparent liquid.

[0029] 3) Heating and stirring in an oil bath at 270°C for 24 hours, the color of the solution changed from wine red to dark green to light yellow, and finally a brown-black transparent colloidal solution was obtained.

[0030] 4) The prepared Ru colloidal solution was left without precipitation for a long time, and different Ru nanoparticles could be obtained by changing the amount of CTAB added. The Ru colloidal solution was treated with acetone to obtain Ru nanoparticles, which were redispersed with ethanol for later use.

[0031] 5) Ru colloid was then added to 10mL of PVP (5mg / ...

Embodiment 3

[0034] Preparation method of RuCu2O photothermal healing band-aid:

[0035] 1) Add RuCl in turn to a 50ml round bottom flask 3 ·xH 2 O TEG solution (20mmol L-1) 1ml, PVP TEG solution (400mmol L-1) 2ml CTAB TEG solution (200mmol L-1) 0.1ml.

[0036] 2) Add an appropriate amount of TEG to make the total volume of the reaction solution 8mL. Stir thoroughly to obtain a wine red transparent liquid.

[0037] 3) Heat and stir in an oil bath at 170°C for 24 hours, the color of the solution changes from wine red to dark green to light yellow, and finally a brown-black transparent colloidal solution is obtained.

[0038] 4) The prepared Ru colloidal solution was left without precipitation for a long time, and different Ru nanoparticles could be obtained by changing the amount of CTAB added. The Ru colloidal solution was treated with acetone to obtain Ru nanoparticles, which were redispersed with ethanol for later use.

[0039] 5) Ru colloid was then added to 10mL of PVP (5mg / mL) and ...

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Abstract

The invention relates to a preparation method for a RuCu2O photo-thermal healing-promoting band-aid. The preparation method specifically comprises the following steps: sequentially adding a TEG solution of RuCl3.xH2O, a TEG solution of PVP and a TEG solution of CTAB; then adding TEG until the total volume of a reaction solution is 8 mL, and carrying out full stirring so as to obtain a wine red transparent liquid; carrying out heating under stirring at 170 DEG C until the color of the solution is changed from wine red to dark green and then to light yellow so as to finally obtain a brownish black transparent colloidal solution; subjecting the prepared Ru colloidal solution to standing for a long time until no precipitate is generated, changing the addition amount of the CTAB so as to be able to obtain different Ru nanoparticles, treating the Ru colloidal solution with acetone so as to obtain Ru nanoparticle precipitates, and re-dispersing the Ru nanoparticle precipitates with ethyl alcohol for subsequent usage; then adding an Ru colloid into a mixed solution of PVP and Cu(NO3)2; and pasting the prepared RuCu2O onto the inner layer of a band-aid so as to obtain the RuCu2O photo-thermal healing-promoting band-aid. The band-aid provided by the invention can effectively remove bacteria at the position of a trauma under near-infrared irradiation, can promote wound healing through copper ions, and provides a novel method for trauma treatment.

Description

technical field [0001] The invention belongs to the field of nanomedicine and relates to a RuCu 2 O A method for preparing a photothermal healing-promoting band-aid. The band-aid can have a high-efficiency bactericidal function and a function of promoting wound healing under near-infrared light. Background technique [0002] Bacteria are still an important factor causing some diseases, and bacterial infection poses a major threat to human health and food safety. At present, antibiotics are a commonly used means of sterilization, but the widespread use of antibiotics has led to the evolution of drug resistance in most bacteria, greatly reducing the efficiency of sterilization. At present, the drug part of the band-aid has little effect on sterilization, and the effect of promoting wound healing is far from the expected result. [0003] Metal antibacterials appeared as early as bacteria were discovered, and have been used by humans for nearly four hundred years. Although mo...

Claims

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Application Information

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IPC IPC(8): A61L15/18A61L15/24A61L15/42A61L15/44A61L15/46
CPCA61L15/18A61L15/24A61L15/44A61L15/46A61L15/42A61L2300/102A61L2300/404A61L2300/412C08L39/06
Inventor 郑斌郭明明明东甘霖
Owner TIANJIN UNIV
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