Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Single-sided needle quality control method based on ultra-high performance liquid chromatography

A quality control method and ultra-high-efficiency liquid phase technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of lack of specificity and quantifiable indicators, no content determination items, etc.

Pending Publication Date: 2020-07-07
ZHUZHOU QIANJIN PHARMA
View PDF1 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

"Hunan Chinese Materia Medica Standards" (2009 Edition) recorded the standards of single-faced needle medicinal materials, and its medicinal parts are the roots and stems of Zanthoxylum bungeanum and Zanthoxylum japonicus, but there is still a lack of specificity and quantifiable indicators, and there is no content determination item

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Single-sided needle quality control method based on ultra-high performance liquid chromatography
  • Single-sided needle quality control method based on ultra-high performance liquid chromatography
  • Single-sided needle quality control method based on ultra-high performance liquid chromatography

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Example 1 Quality standard control method of Shuangmianzhen decoction pieces—fingerprint and content determination

[0054] 1. Materials

[0055] 1.1 Instrument

[0056] Waters Acquity UPLC H-Class ultra-high performance liquid chromatography system, Empower workstation, including quaternary gradient pump, automatic sampler, ultraviolet detector (Waters company). SQP electronic balance (Sartorius Scientific Instrument Co., Ltd.), P20-Y laboratory ultra-pure water machine (Hunan Kelton Water Co., Ltd.), KQ-500DE CNC ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd.), SZ-500A-3 ultra-high-speed multifunctional pulverizer (Yongkang Shanzhu Trading Co., Ltd.), SCAA-104 (13mm, 0.22μm) organic phase needle filter (Shanghai Anpu Experimental Technology Co., Ltd.), etc.

[0057] 1.2 Reagents

[0058] Reference substance magnolialine (Chengdu Ruifensi Biotechnology Co., Ltd., batch number, M-026-170612, purity ≥ 98%), acanthine chloride (Chengdu Ruifensi Biotechnolo...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a single-sided needle quality control method based on ultra-high performance liquid chromatography. According to the method, the content of nitidine chloride in a sample is detected by using an ultra-high performance liquid chromatography technology, and the content is required to be not lower than 0.001%. According to the method, a common fingerprint spectrum of zanthoxylum nitidum and zanthoxylum nitidum from different producing areas is established by utilizing an ultra-high performance liquid chromatography technology for the first time, and qualitative and quantitative analysis is performed on differential alkaloids, so that a quality control detection marker and a content standard thereof are defined; compared with a fingerprint spectrum established by an existing high performance liquid chromatography technology, the method has the advantages that the analysis speed is high, the analysis time can be obviously shortened, the sensitivity is high, the separation effect is good, the repeatability is good, the operability is high, and a scientific basis and a feasible quality control standard are provided for single-sided needle quality control.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine quality control. More specifically, it relates to a method for quality control of single-sided needles based on ultra-high performance liquid chromatography. Background technique [0002] Zanthoxylum dissitum Hemsley is the dried root and stem of Zanthoxylum dissitum Hemsley or Z. echinocarpum Hemsley, and Zanthoxylumnitidum (Roxb.) DC is the dried root of Zanthoxylumnitidum (Roxb.) DC. The two grow in mountainous forests such as Guangdong, Guangxi, Hunan, and Yunnan in my country. It has the effects of promoting blood circulation and dispelling blood stasis, expelling wind and activating collaterals, renewing tendons and bones, and is used to treat bruises, fractures, etc. At present, Shuangmianzhen is used as the main component of Fuke Qianjin Tablets in clinical practice, mainly for the treatment of endometritis, pelvic inflammatory disease, chronic cervicitis and other g...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): G01N30/86G01N30/02G01N30/34G01N30/74G01N30/06
CPCG01N30/8686G01N30/02G01N30/34G01N30/74G01N30/06G01N30/8634G01N30/8637
Inventor 龚云凌勇根何娟娟廖端芳林丽美
Owner ZHUZHOU QIANJIN PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com