Application of N6022 in prevention and treatment of aortic dissection and aortic aneurysm

A technology for aortic dissection and aortic aneurysm, applied in the direction of medical preparations containing active ingredients, cardiovascular system diseases, organic active ingredients, etc., to reduce the occurrence of hematoma, reduce excessive collagen deposition on the vessel wall, and maintain integrity Effect

Active Publication Date: 2020-08-14
NANJING MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, whether N6022 can improve aortic dissection and aortic

Method used

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  • Application of N6022 in prevention and treatment of aortic dissection and aortic aneurysm
  • Application of N6022 in prevention and treatment of aortic dissection and aortic aneurysm
  • Application of N6022 in prevention and treatment of aortic dissection and aortic aneurysm

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: Inhibitory effect of N6022 on occurrence and rupture of aortic dissection

[0020] In order to explore the effect of N6022 on the occurrence and rupture of aortic dissection, we selected SPF grade 4-week-old C57BL / 6 mice (purchased from the Medical Experimental Animal Center of Nanjing Medical University) and randomly divided them into five groups: solvent control group (Control+ DMSO), aortic dissection model solvent control group (BAPN+DMSO) and three different N6022 concentrations (0.01mg / kg / day, 0.1mg / kg / day, 1mg / kg / day) aortic dissection model administration groups. Wherein the model of aortic dissection is when the mice were 4 weeks old, by infiltrating β-aminopropionitrile (BAPN) 1g / kg / day in the drinking water, and injecting different concentrations of N6022 (0.01mg / kg / day, 0.1mg / kg / day, 1mg / kg / day), the survival of the mice was observed every 5 days, and after 4 weeks, the aorta of the mice was isolated, and the incidence rate and rupture rate of ao...

Embodiment 2

[0023] Example 2: Inhibitory effect of N6022 on formation and rupture of aortic aneurysm

[0024] In order to explore the effect of N6022 on tumor formation and rupture in aortic aneurysm model mice, we selected SPF grade 8-week-old male ApoE - / - Mice (purchased from Nanjing Junke Bioengineering Co., Ltd.) were randomly divided into three groups: solvent control group (Saline+DMSO), aortic aneurysm model solvent control group (AngII+DMSO) and aortic aneurysm model administration group ( AngII+N6022). That is, when the mice were 8 weeks old, an osmotic micropump (Alzet, USA, 2004 model) was implanted subcutaneously through the back, the control group was given normal saline, the aortic aneurysm model solvent control group and the aortic aneurysm model administration group were given Ang II ( 1000ng / kg / min), and the control solvent DMSO or N6022 (0.1mg / kg / day) was injected into the tail vein. The mortality rate of mice was observed every 5 days, and the formation of aortic ane...

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PUM

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Abstract

The invention discloses application of N6022 in treatment of aortic dissection and aortic aneurysm, and relates to the field of cardiovascular diseases. In mouse models of aortic dissection and aorticaneurysm, dilation of aorta can be inhibited after intravenous injection of the N6022 into tail veins, thereby reducing incidence and mortality of aortic dissection and aortic aneurysm; and moreover,the N6022 is capable of reducing rupture of aortic aneurysm, inhibiting occurrence of hematoma in inner walls of lumen and excessive collagen deposition on vascular walls, maintaining integrity of elastic fibers in the vascular walls, and treating the aortic dissection and the aortic aneurysm. The application of the N6022 in the treatment of the aortic dissection and the aortic aneurysm opens upa new application field of the N6022, and provides a meaningful reference for the prevention and the treatment of the aortic dissection and the aortic aneurysm diseases as well as improvement of vascular lesions.

Description

technical field [0001] The invention belongs to the technical field of aortic dissection and aortic aneurysm treatment, and in particular relates to the application of N6022, a nitrosoglutathione reductase (GSNOR) inhibitor, in the prevention and treatment of aortic dissection and aortic aneurysm. Background technique [0002] Aortic dissection and aortic aneurysm are the most serious large-vessel diseases in aortic diseases, and their pathological manifestations are progressive dilation of the aorta. Due to their characteristics of insidious onset and fatal rupture, they have become a major public health problem. In the early stage of the disease, the middle layer of the blood vessel undergoes structural abnormalities such as degeneration and degeneration, and usually no specific symptoms or signs appear before the vessel ruptures; as the diameter of the tumor increases, the probability of rupture increases significantly, accompanied by intimal tear and false lumen After tu...

Claims

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Application Information

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IPC IPC(8): A61K31/4178A61P9/00A61P9/14
CPCA61K31/4178A61P9/00A61P9/14
Inventor 季勇谢利平张曦月缪青张益华高婕
Owner NANJING MEDICAL UNIV
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