Bionics lung gas-liquid exposing micro fluidic chip administration and cell culture system

Abstract

The invention relates to a bionics lung gas-liquid exposing micro fluidic chip administration and cell culture system. The bionics lung gas-liquid exposing micro fluidic chip administration and cell culture system comprises an exposing chamber, a micro fluidic exposing chip, a micro fluidic cell culture chip, and a basal slide glass, wherein a polycarbonate membrane is arranged between the micro fluidic exposing chip and the micro fluidic cell culture chip; an exposing chip communicating pipeline is formed in the micro fluidic exposing chip; a micro fluidic cell culture chip communicating pipeline is formed in the micro fluidic cell culture chip; the exposing chip communicating pipeline in the polycarbonate membrane is used for culturing one kind of cells; and the micro fluidic cell culture chip communicating pipeline in the basal slide glass is used for culturing the other kind of cells. Compared with the prior art, the bionics lung gas-liquid exposing micro fluidic chip administration and cell culture system disclosed by the invention is simpler in integrated operation, on-line monitoring can be realized, and the bionics lung gas-liquid exposing micro fluidic chip administrationand cell culture system has the advantages of being high in reliability and authenticity and the like; besides, a micro fluidic biochip technique is introduced, so that experiment cost and periods arereduced; and the chip pipeline is freely designed, so that the experiment has high freedom degree.

Description

technical field [0001] The invention belongs to the bionic field of biological microfluidic chips, in particular to a microfluidic chip drug delivery and cell culture system for bionic lung gas-liquid exposure. Background technique [0002] While the lung is the respiratory organ of the human body, it is also an important hematopoietic organ of the human body. Studies have shown that more than half of the platelets in a normal person's body come from the lungs. However, due to environmental pollution, the invasion of biological viruses and some aerosol particles, coupled with people's overwork, alcoholism, and bad work and rest habits, the human lungs are extremely vulnerable to damage. Therefore, it is particularly important to study the toxicity and pharmacology of lung organs. The current way of pulmonary administration is mostly nasal administration. Nasal administration is to atomize the drug through a nebulizer, so that the drug enters the human body in the form of ae...

AI Technical Summary

Problems solved by technology

However, the commonly used bionic lung drug delivery systems in various researches are mostly single-layer lung cells or living small animals. In the base, the gas-liquid environment in which the lungs are located cannot be well simulated

The latter is more expensive, the cultivation experiment period is longer, and the operation is more complicated

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