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48 results about "Polycarbonate membrane" patented technology

Graphene oxide and sodium alginate composite membrane for extracting ocean osmotic energy and preparation method of graphene oxide and sodium alginate composite membrane

The invention discloses a preparation method of a graphene oxide sodium alginate composite membrane for extracting ocean osmotic energy. The preparation method specifically comprises the following steps: step 1, preparing a sodium alginate solution; step 2, preparing a graphene oxide solution; 3, putting the sodium alginate solution into the graphene oxide solution, and carrying out electromagnetic stirring to obtain a mixed dispersion liquid; step 4, taking a polycarbonate film, taking the polycarbonate film as a substrate, putting the polycarbonate film into a trace suction flask, taking the mixed dispersion liquid, and performing vacuum suction filtration on the mixed dispersion liquid in the trace suction flask to obtain a polycarbonate film covered with a graphene oxide sodium alginate composite film; step 5, stripping the polycarbonate film covered with the graphene oxide and sodium alginate composite film, and naturally drying to obtain the graphene oxide and sodium alginate composite film for extracting the ocean osmotic energy. The invention further discloses the graphene oxide and sodium alginate composite membrane for extracting the ocean osmotic energy. The prepared composite membrane has the advantages of being high in power density, good in stability and high in economic value.
Owner:HAINAN UNIV

Therapeutic nano-vesicle preparation rich in mitochondrial functional protein, preparation method of therapeutic nano-vesicle preparation and application of therapeutic nano-vesicle preparation in treatment of radioactive skin injury

The invention discloses a therapeutic nano-vesicle preparation rich in mitochondrial functional protein, a preparation method of the therapeutic nano-vesicle preparation and application of the therapeutic nano-vesicle preparation in treatment of radioactive skin injury. The preparation method comprises the following steps: culturing, amplifying and cleaning umbilical cord mesenchymal stem cells, dispersing the umbilical cord mesenchymal stem cells in a suspension, mechanically extruding the umbilical cord mesenchymal stem cells into a crude solution through a multistage aperture polycarbonate membrane, and centrifuging, concentrating and purifying the crude solution to obtain the preparation. The preparation has the remarkable advantages that local administration can be realized, inflammation can be quickly inhibited, oxidative stress is reduced, and a repair pathway is activated, so that the preparation is suitable for treating acute radioactive skin injury; the preparation method is easy to standardize and scale, high in stability and convenient for emergency storage and delivery, and avoids the defects of cell therapy; a plurality of targets such as immune inflammation, oxidative stress and the like can be synergistically regulated, the biological effect of hUMSCs is simulated and partially replaced, and the limitation caused by the cell survival rate and the microenvironment dependency is avoided; the key function of hUMSCs is covered in function, and the clinical feasibility, safety and emergency suitability of the application level are higher.
Owner:FIRST AFFILIATED HOSPITAL OF DALIAN MEDICAL UNIV

Artificial nano-vesicles derived from human umbilical cord mesenchymal stem cells induced by natural products and application of artificial nano-vesicles in ischemic diseases

The invention discloses a natural product-induced artificial nano-vesicle derived from human umbilical cord mesenchymal stem cells and application of the natural product-induced artificial nano-vesicle in ischemic diseases. The preparation method of the nano vesicle derived from the human umbilical cord mesenchymal stem cells comprises the following steps: S1, inoculating the human umbilical cord mesenchymal stem cells to a 3D microcarrier; then adding traditional Chinese medicine active ingredients to activate the human umbilical cord mesenchymal stem cells, continuing to culture, cracking the microcarrier, and harvesting cells; s2, dispersing the human umbilical cord mesenchymal stem cells obtained in S1 to obtain a suspension, extruding the suspension through a polycarbonate film, and then discarding large particles by adopting a gradient centrifugation method to obtain the nano-vesicles. Compared with naturally secreted exosomes, the exosome has the advantages that the yield is increased, the treatment efficiency is improved, the production cost is reduced, and compared with stem cells, the problems of low transplantation rate and the like are avoided. The stem cells are pretreated based on the traditional Chinese medicine, the vesicles are extracted by utilizing an extrusion method, and the yield and the treatment efficiency of the nano vesicles are remarkably improved.
Owner:BEIJING UNIV OF CHINESE MEDICINE

Inflammation memory activated epidermal stem cell bionic vesicle as well as preparation method and application thereof

The invention belongs to the technical field of biological medicines, and particularly discloses an inflammatory memory activated epidermal stem cell bionic vesicle as well as a preparation method and application thereof. The epidermal stem cell bionic vesicle is obtained by adding lipopolysaccharide into a serum-free culture medium to induce and culture epidermal stem cells, continuously extruding a cell suspension through an extruder of a micron-sized polycarbonate film, and carrying out centrifugal separation. The LEM preparation method provided by the invention is simple, efficient and good in biocompatibility, not only retains the repair characteristic of mother cells, but also can induce neutrophil to transform to N2 phenotype, and has a better inflammation regulation effect, so that wound healing and tissue repair are promoted, and the LEM has a better application prospect and a better application value.
Owner:GUANGDONG AIE BIOSCIENCE CO LTD

Mannosylated hybrid membrane packaged Cu / Zn-MOF drug delivery system and preparation method and application thereof

The invention belongs to the technical field of drug delivery, and particularly relates to a mannosylation hybrid membrane encapsulated Cu / Zn-MOF drug delivery system and a preparation method and application thereof.The drug delivery system comprises mannosylation hybrid membrane encapsulated H-151-loaded Cu / Zn-MOF, the hybrid membrane is prepared by fusing lipidosome and a macrophage cell membrane, and the lipidosome and the macrophage cell membrane are combined to form the mannosylation hybrid membrane loaded H-151-loaded Cu / Zn-MOF drug delivery system. The preparation method comprises the following steps: dissolving H-151 in dimethyl sulfoxide, dropwise adding a Cu / Zn-MOF methanol suspension, stirring, centrifuging, and washing to obtain H-151-loaded Cu / Zn-MOF; mixing the macrophage membrane with lipidosome, performing ultrasonic treatment, and extruding through a polycarbonate membrane to obtain a hybrid membrane; preparing lipidosome by adopting DSPE-PEG-Man, and fusing the lipidosome with a macrophage membrane to obtain a mannosylation hybrid membrane; the H-151-loaded Cu / Zn-MOF is mixed with the mannosylation hybrid membrane, incubation and centrifugation are performed, and the H-151-loaded Cu / Zn-MOF encapsulated by the mannosylation hybrid membrane is obtained. The mannosylation hybrid membrane encapsulated Cu / Zn-MOF drug delivery system has the functions of accurate delivery, intelligent release, oxidation resistance and inflammation resistance, and accurate and efficient treatment of inflammatory diseases is achieved.
Owner:THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY

Myopia prevention and control lens

The utility model relates to the technical field of myopia prevention and control lenses, in particular to a myopia prevention and control lens, which comprises a resin lens, a central micro lens is fixedly embedded in the middle of the resin lens, an edge micro lens is fixedly sleeved on the circumference of the outer wall of the central micro lens, the edge micro lens is divided into four quadrants, the bottom end of the resin lens is provided with an anti-blue-light layer, the bottom end of the anti-blue-light layer is provided with an anti-ultraviolet layer, the bottom end of the anti-ultraviolet layer is provided with a bonding layer, and the bottom end of the bonding layer is provided with an anti-scratch wear-resistant layer. According to the myopia prevention and control lens, the blue light prevention capability of the lens can be improved and eyes of a user can be protected through the blue light prevention layer made of the blue PET film layer, the eyes can be prevented from being damaged by ultraviolet light through the ultraviolet-proof layer made of the polycarbonate film layer, and the scratch-proof and wear-resistant capability of the lens can be improved through the scratch-proof and wear-resistant layer made of the nano-particle resin layer; the service life of the lens is prolonged.
Owner:CHENGDU CHINA VISION MICRO TECHNOLOGY CO LTD

A polyoxymethylene-formaldehyde membrane and its production and use

PendingCN122399581APolymer sciencePolycarbonate
This invention belongs to the field of polymer membrane material technology and discloses a method for extracting uranium (UO2) from seawater. 2+ This invention discloses a novel separation membrane material, specifically a amine-oxime-modified polycarbonate membrane, its preparation method, and its applications. The invention uses polycarbonate (PC) as a matrix. First, cyano-modified polycarbonate (PCAN) is prepared by grafting cyano groups. Then, PC and PCAN are blended, and a base membrane material is prepared using a phase inversion method. Finally, through in-situ amine-oxime modification, an amine-oxime-modified polycarbonate membrane (PCAO) is obtained, which possesses advantages such as high adsorption capacity, easy recovery, good stability, and excellent recyclability. Furthermore, the polycarbonate membrane modified with amine-oxime groups exhibits highly efficient selective adsorption capacity for uranium, enabling the effective development of uranium resources in seawater. This not only alleviates the domestic shortage of these key energy materials but also significantly improves economic benefits.
Owner:HAINAN UNIV

Hard coating liquid and preparation method thereof, hard coating film for HUD dust cover and preparation method of hard coating film

The invention provides a hard coating liquid and a preparation method thereof, a hard coating film for an HUD dustproof cover and a preparation method of the hard coating film, and belongs to the technical field of vehicle HUD. The hard coating liquid comprises a resin matrix, the resin matrix comprises a swelling monomer, the swelling monomer comprises at least one of an amide group, a cyclic ether oxygen group and bisphenol A, and the mass ratio of the swelling monomer in the resin matrix is 10 wt%-30 wt%. The swelling monomer containing at least one of an amide group, a cyclic ether oxygen group and bisphenol A is selected and added into the hard coating liquid arranged on the surface of the polycarbonate film, and the swelling monomer has the ability to swell polycarbonate, so that after the hard coating liquid is arranged on the surface of the polycarbonate film, the swelling monomer partially permeates into the surface layer of the polycarbonate, and the hardness of the hard coating liquid is improved. And in the subsequent UV curing process, an interpenetrating network is formed between the polycarbonate surface layer and the hard coating surface layer, so that the prepared hard coating has high hardness, abrasion resistance, solvent wiping resistance and relatively high adhesive force under high temperature and high humidity for a long time.
Owner:GUANGDONG LIYUAN NEW MATERIALS TECHNOLOGY CO LTD

Hybrid fiber fabric reinforced thermoplastic composite laminate and method of making and use thereof

The application relates to the technical field of composite materials, and discloses a mixed-fiber fabric reinforced thermoplastic composite material laminated plate and a preparation method and application thereof. The laminated plate is obtained by die molding a preformed body, wherein the preformed body comprises a plurality of mixed-fiber fabrics and thermoplastic resin films which are sequentially stacked in layers, and the thermoplastic resin film is selected from one or more of a polyamide film, a polyphenylene sulfide film, a polyether ether ketone film, a poly (aryl ether ketone) film, a polycarbonate film and a polysulfone film. The prepared thermoplastic laminated plate is uniform in resin distribution and excellent in comprehensive mechanical properties.
Owner:CHINA PETROLEUM & CHEMICAL CORP +1

Protective device capable of removing electric control cabinet touch screen

The utility model discloses a protective device capable of removing a touch screen of an electric control cabinet, the electric control cabinet is provided with a touch screen protruding out of the surface of the electric control cabinet, the protective device comprises a cover body, the cover body comprises a transparent protective film, a positioning frame and a connecting frame which are sequentially arranged from front to back, the transparent protective film is a polycarbonate film or an acrylic acid film, and the connecting frame is a transparent protective film. The positioning frame is arranged at the position, close to the edge, of the rear side of the transparent protective film, the positioning frame is a flexible frame, the connecting frame is a soft magnetic strip frame, a containing space used for containing the touch screen is defined by the transparent protective film, the positioning frame and the connecting frame jointly, and the cover body covers the touch screen and is magnetically attracted to the surface of an electric control cabinet through the connecting frame. The touch screen is located in the containing space of the cover body. Compared with the prior art, the touch screen has the advantages that the touch screen is protected from potential damage such as dust, greasy dirt and cleaning agents, the touch screen can be operated at the same time, and installation and removal are convenient and fast.
Owner:CHINA TOBACCO ANHUI IND CO LTD

A polycarbonate film flow coating device

The application relates to the technical field of polycarbonate film production, in particular to a polycarbonate film flow coating device. The existing flow coating device is inconvenient for limiting a winding drum, the winding drum is prone to moving during winding, the winding quality is affected, and bulging is prone to occurring during polycarbonate film cooling; after coating is completed, the tail end of the polycarbonate film is prone to being damaged and polluted due to the lack of support. The polycarbonate film flow coating device comprises a base plate and the like; a vertical plate is fixedly connected to the base plate; a winding motor and a rotating motor are fixedly connected to one side of the vertical plate; a forming mechanism is arranged on one side of the vertical plate; and the forming mechanism is connected with the winding motor and the rotating motor. The winding drum is not prone to moving during winding after being limited, and the winding quality is improved.
Owner:ZHUZHOU DIBO PHOTOELECTRIC MATERIALS CO LTD

Method for rapidly extracting nucleic acid in grain and detecting transgenic grain

The invention discloses a method for rapidly extracting nucleic acid in grain and detecting transgenic grain, which comprises the following steps: grinding grain seeds into powder, splitting, adsorbing nucleic acid by using a polycarbonate film, mixing the polycarbonate film after adsorbing the nucleic acid with an amplification reaction solution containing a transgenic amplification sequence for in-situ amplification, and detecting the transgenic grain by using the in-situ amplification reaction solution. And judging whether the grain seeds are transgenic grains or not according to an in-situ amplification detection result. According to the invention, only DNA in a grain sample is adsorbed by the membrane and is separated from impurities along with the membrane. Endogenous interferents in the grain and exogenous interferents in the cracking reagent are retained in the original cracking solution. According to the present invention, the grain DNA-enriched membrane obtained from the grain sample through the grain genome DNA membrane enrichment rapid extraction method can be directly used for the in-situ amplification reaction without the cleaning and elution steps, such that the operation process is simplified, and the large loss of the nucleic acid is avoided. And the method is not influenced by interferents, and the volume of the cracking product solution does not need to be accurately sucked.
Owner:ZHEJIANG UNIV +1

Tripterygium wilfordii exosome-like nano-vesicle modified prussian blue nano-material and application thereof

The invention discloses a tripterygium wilfordii exosome-like nano-vesicle modified Prussian blue nano-material and application thereof, and belongs to the field of nano-material synthesis. The tripterygium wilfordii exosome-like nano-vesicle modified prussian blue nano-material is a nano-scale particle, is of a square structure, and comprises a square prussian blue nano-particle and a tripterygium wilfordii exosome-like nano-vesicle coated outside the prussian blue nano-particle. The preparation method comprises the following steps: adding tripterygium wilfordii exosome nano-vesicles PELNVs into a Prussian blue nano-particle solution, mixing, and carrying out physical extrusion on the mixed system to enable the mixed system to repeatedly pass through a polycarbonate film. The obtained tripterygium wilfordii exosome-like nano-vesicle modified Prussian blue nano-material has excellent photothermal conversion performance and oxidation resistance, the hemolysis rate is kept at an extremely low level, the cytotoxicity is low, and the tripterygium wilfordii exosome-like nano-vesicle modified Prussian blue nano-material is used for photothermal therapy of rheumatoid arthritis, has excellent photothermal therapy capacity, and is good in biological safety and wide in application prospect.
Owner:HUBEI UNIV

Biological reaction vessel for in-vitro culture of tissue engineering skin cells

The utility model relates to the technical field of cell culture, and discloses a biological reaction vessel for in-vitro culture of tissue engineering skin cells, which comprises a liquid storage tank, the top of the liquid storage tank is fixedly connected with a culture bin through supporting legs, and the culture bin is used for culturing cell samples. A plurality of placing grooves are formed in a supporting ring arranged at the top of a culture bin to place polycarbonate films, so that multiple groups of cells can be conveniently cultured by adopting the same culture solution, and floating rods are arranged on the outer walls of the polycarbonate films, so that the polycarbonate films can float on the liquid surface, and the culture efficiency is improved. In order to facilitate the culture mode of skin cells on a polycarbonate film, gas-liquid interface culture is mainly adopted, the gas-liquid interface culture method can realize the multi-layer growth of the cells, the cells in contact with the liquid level of a culture medium have growth and reproduction capabilities in the culture process, and only the cells in contact with air are keratinized, so that the actual growth environment of the skin cells can be simulated, and the skin cells can be effectively cultured. And the cultured data is more referential.
Owner:JIANGSU RE STEM BIOTECH

High-polarization dustproof plate for vehicle-mounted HUD and preparation method of high-polarization dustproof plate

The invention belongs to the technical field of optical devices, and discloses a high-polarization dustproof plate for a vehicle-mounted HUD (Head Up Display) and a preparation method of the high-polarization dustproof plate. The polarization dustproof plate comprises a polarization element sub-layer, a first optical compensation layer and a second optical compensation layer, wherein the polarization element sub-layer is clamped between the first optical compensation layer and the second optical compensation layer; wherein the first optical compensation layer and the second optical compensation layer are both polycarbonate films, and the compensation value Re of the polycarbonate films meets the following relational expression: Re < = 50nm or Re > = 3000nm; the polarizer layer is a polyvinyl alcohol polarizing film, and the degree of polarization of the polyvinyl alcohol polarizing film is larger than or equal to 99%. The optical compensation layers with low compensation value or high compensation value functions are arranged on the two sides of the polarization element sub-layer, and the polarization element sub-layer with high polarization degree is adopted, so that the problems of rainbow lines and ghosting are solved, glare and reflection are reduced, the display definition is improved, and the application requirement of large-size HUD projection display can be met.
Owner:FOSHAN WEIDA OPTOELECTRONIC MATERIALS CO LTD

Daptomycin nano-formulation, method for preparing same, and use thereof

The present invention relates to the field of pharmaceutical technology, and in particular, to a daptomycin nano-FORMULATION, a method for preparing same, and use thereof. The method comprises: A, encapsulating daptomycin with a copolymer poly(lactic-co-glycolic acid) to give a nanoparticle (NP); and B, sonicating a cell membrane vesicle overexpressing RANK and the nanoparticle (NP) in a water bath for 3 min, and then sequentially extruding the mixture through polycarbonate membranes of 800 nm, 400 nm, and 200 nm to give the daptomycin nano-formulation. The weight ratio of the membrane protein to PLGA is 0.25. By the method of the present invention, a daptomycin nano-formulation targeting rheumatoid arthritis is successfully prepared. The daptomycin nano-formulation prepared by the present invention has good stability. The daptomycin nano-formulation of the present invention has good therapeutic effects against RA.
Owner:SICHUAN UNIV

Exosome simulant preparation device and exosome simulant preparation method

The invention provides an exosome simulant preparation device and an exosome simulant preparation method. The exosome simulant preparation device comprises a positioning sleeve, a polycarbonate film located in the positioning sleeve, two injectors arranged on the two sides of the polycarbonate film respectively and two columns used for assembling the injectors. The syringe comprises a syringe needle and a syringe barrel which are detachably arranged, the syringe needle is fixed in the column body, and an inserting groove corresponding to the syringe barrel is formed in the side, away from the polycarbonate film, of the column body. The cylinders and the sealing rings are arranged on the two sides of the polycarbonate film to form a closed flow path, the contamination rate of exosome simulants is reduced, the syringe needle and the syringe barrel are detachably and rapidly assembled, consumable replacement can be facilitated, the operation efficiency and the preparation efficiency are improved, and meanwhile the device is simple and has the advantages of being low in cost and convenient to operate. The method has the advantages of high yield, stable yield and high output quality, and solves the problems of low yield of natural exosomes, high cost, time and labor consumption and high content heterogeneity of a separation and purification method.
Owner:JIANGXI ACAD OF MEDICAL SCI

Bionic nano-composite, preparation method thereof and application of bionic nano-composite in tumor diagnosis and treatment

The invention provides a bionic nano-composite, a preparation method thereof and application of the bionic nano-composite in tumor diagnosis and treatment, and belongs to the technical field of medicines. The preparation method comprises the following steps: extracting centella asiatica and ginseng polysaccharide, reacting with vitamin C to form glucoside, uniformly mixing with Mg2Si nanoparticles, gadolinium diamine, calcium chloride powder and adriamycin, ball-milling to prepare a compound, coating Au nanocage / silk fibroin peptide microspheres to form an inclusion compound, mixing with folic acid modified bionic liposome, adding into water, repeatedly extruding by using a liposome extruder of a polycarbonate film, and drying to obtain the folic acid modified bionic liposome. The bionic nano-composite is prepared. The bionic nanocomposite prepared by the invention increases targeted delivery of drugs to tumor tissues, improves drug resistance, reduces chemotherapeutic drug concentration, reduces side effects, can protect organs such as liver, heart and the like from being infringed by chemotherapeutic drugs, improves drug effects, has a relatively good anti-tumor effect, especially pancreatic cancer tumors, has a relatively good diagnosis and treatment effect, and has good application prospects. Wide application prospects are realized.
Owner:NINGBO UNIV

Polycarbonate film producing and processing device

The utility model relates to the technical field of polycarbonate film processing, in particular to a polycarbonate film producing and processing device which comprises a processing table, a controller is arranged on one side of the processing table, an installation opening is formed in one side of the processing table, and two connecting frames are symmetrically arranged in the installation opening in parallel. The machining device comprises a machining table, two connecting frames are arranged on the machining table, an adjusting assembly is arranged between the two connecting frames, guiding and shaping assemblies are arranged in the two connecting frames, two guiding assemblies are arranged on one side of the machining table, and the two guiding assemblies are distributed in a high-low structure. Therefore, the distance between the connecting frames can be accurately adjusted, the production requirements of polycarbonate films of different specifications can be quickly met, and the production efficiency and the universality of equipment are improved.
Owner:SHENZHEN KIAER PLASTIC ELECTRONICES CO LTD

Multilayer body

Provided is a multilayer body having a protective film including an adhesive layer on the surface of a thin polycarbonate film, the multilayer body being less susceptible to the occurrence of orange peel on the surface of the polycarbonate film when the protective film is peeled off. The multilayer body has a polycarbonate film having a thickness of 20-75 [mu] m and a protective film provided on at least one surface of the polycarbonate film, the protective film has an adhesive layer that is peelable from the polycarbonate film and a resin-containing layer, the adhesive layer is in contact with the polycarbonate film, and when the polycarbonate film is peelable from the multilayer body, the adhesive layer is in contact with the polycarbonate film. The arithmetic average waviness Ma of the corrugations of the adhesive layer is 0.01-0.12 [mu] m, and the corrugations do not include corrugations having a corrugation width of less than 500 [mu] m and greater than 3000 [mu] m.
Owner:MITSUBISHI GAS CHEM CO INC

Track etching gradient pore density polycarbonate film and preparation method thereof

The invention discloses a track etching gradient pore density polycarbonate film and a preparation method thereof, and relates to the field of polycarbonate film preparation, the preparation method comprises the following steps: forming a latent track density gradient on a polycarbonate film a according to a preset pattern by an irradiation method to obtain a polycarbonate film b; etching the polycarbonate film b for the first time by matching an alternating electric field with an etching solution to form an initial hole with a non-circular hole opening and a quasi-circular hole wall, so as to obtain a polycarbonate film c; etching the polycarbonate film c for the second time, and constructing a conical pore channel to obtain a polycarbonate film d; and carrying out termination and post-treatment on the polycarbonate film d to obtain the gradient pore density polycarbonate film. Through the synergistic effect of the gradient hole density, the non-circular hole openings and the conical hole channels, graded interception and internal deep loading of particles are achieved, the long-term operation stability, the impact load resistance and the filtering efficiency of the membrane are effectively improved, and meanwhile the cleaning frequency and the operation cost are reduced.
Owner:DONGJIANG NUCLEAR TECHNOLOGY APPLICATION (GUANGDONG) CO LTD

Preparation process of lutein liposome for improving bioavailability

The invention provides a lutein liposome preparation process for improving bioavailability. The lutein liposome preparation process comprises the following steps: S1, preparing raw materials; s2, preparing a lutein lipid solution: dissolving lutein and a lipid phase in a trichloromethane methanol solution to obtain the lutein lipid solution; s3, forming a thin film: carrying out rotary evaporation on the lutein lipid solution, and removing the organic solvent to form a uniform thin film; s4, preparation and hydration of a composite polyphenol solution: dissolving composite polyphenol in a thermal phosphate solution to obtain the composite polyphenol solution, dropwise adding the composite polyphenol solution into the film for hydration, and performing rotary evaporation to remove an organic solvent to form a uniform film; s5, redissolution and ultrasonic treatment: adding the film into a bile salt solution for redissolution, performing ultrasonic treatment under the ice-water bath stirring condition, and continuing stirring after ultrasonic treatment; and S6, centrifuging and purifying: centrifuging the dispersion liquid to remove unembedded xanthophyll, extruding the dispersion liquid through a polycarbonate film, and removing excessive composite polyphenol through a sephadex column to obtain the composite polyphenol xanthophyll liposome. By adopting the preparation process, the bioavailability of the xanthophyll can be improved.
Owner:SHANYANG H&Y BIOTECH CO LTD

Improved filtering device of flow cell of flow cell method dissolution instrument and method for measuring dissolution rate of ibuprofen suspension

The invention discloses an improved filtering device of a flow cell of a flow cell method dissolution instrument and a method for measuring the dissolution rate of an ibuprofen suspension. The filtering device is sequentially composed of a screen, a glass fiber membrane, a polycarbonate membrane and a screen. The polycarbonate film has outstanding impact toughness, transparency and dimensional stability, is high in pressure resistance and wide in chemical compatibility, and can be used for an extrusion process of lipidosome. According to the flow pool dissolution method, the polycarbonate film can prevent a flow path on the filter film cover from being blocked, most of the blocking problems are solved, the good pressure resistance of the polycarbonate film can assist drugs, especially drugs with multiple auxiliary materials and high viscosity, to be subjected to dissolution rate testing smoothly by adopting the flow pool dissolution rate method, and the applicability of the novel dissolution method of the flow pool dissolution method is improved.
Owner:GUANGZHOU DRUG CONTROL INST

Preparation method and application of autologous cell-derived nanovesicles loaded with miRNA in intervertebral disc degeneration

The application provides a preparation method of autologous cell source nanovesicle loaded miRNA in intervertebral disc degeneration, and steps include: (1) adding miRNA mimics into PBS resuspension of nucleus pulposus cells; (2) using polycarbonate membrane with gradient pore size reduction and NV preparation instrument to extrude the nucleus pulposus cells, and obtaining autologous cell source NV loaded miRNA after sterilization and centrifugation; the autologous cell source nanovesicle loaded miRNA is used in preparation of drugs and complex drugs for treating intervertebral disc degeneration. The application provides a method of autologous cell source nanovesicle loaded miRNA, stress response key miRNA in intervertebral disc degeneration and biological functions thereof are recognized, and autologous nucleus pulposus cell source NV is used to load the stress response key miRNA, effective delivery of miRNA in intervertebral disc is realized, and finally the function of delaying intervertebral disc degeneration under abnormal stress load is played.
Owner:THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV

A method for preparing broadband strong microwave absorbing magnetic metal nanotubes

The present invention relates to a preparation method of a broadband strong microwave absorbing magnetic metal nanotube, which comprises the following steps: (1) in a vacuum environment, using heavy ions provided by a Lanzhou heavy ion accelerator to vertically and uniformly irradiate a 6-30 μm thick polycarbonate film to form a heavy ion track template; (2) the heavy ion track template is ultraviolet sensitized and chemically etched by an etching solution under ultrasonic conditions to obtain an etched template; (3) the etched template is ultrasonically cleaned and dried, and then completely immersed in a Sn (II) solution for pre-activation; after the pre-activation is completed, it is washed and dried to obtain a pre-activated template; (4) the pre-activated template is completely immersed in a palladium solution for activation, and after the activation is completed, it is washed and dried with deionized water to obtain an activated template; (5) the activated template is immersed in a chemical plating solution for nickel deposition to obtain a Ni nanotube with uniform wall thickness. The present invention has low cost and convenient operation, and the obtained nanotube has excellent microwave absorption performance.
Owner:LANZHOU UNIV

Preparation method and application of natural polysaccharide-based micro-nano motor

The invention discloses a preparation method of a natural polysaccharide-based micro-nano motor, and the method comprises the following steps: (1) preparing a polysaccharide-based microtube: taking a polycarbonate film as a template, and forming an alternately assembled film layer of chitosan and kappa-carrageenan on the template through a soaking assembly method or a pressure assembly method; (2) preparation of a nano-motor: cross-linking glucose oxidase on the polysaccharide-based microtube through a glutaraldehyde cross-linking method to form an enzyme-driven micro-nano-motor; or the ferroferric oxide and the polysaccharide-based microtube are crosslinked to form a magnetic drive micro-nano motor; or the nano platinum and the polysaccharide-based microtube are crosslinked to form the platinum-driven micro-nano motor. The preparation method disclosed by the invention is simple and safe, the prepared micro-nano motor has good autonomous motion performance and also has load performance so as to avoid degradation of effective active components, and the magnetically-driven and platinum-driven micro-nano motor has excellent photothermal conversion performance.
Owner:DALIAN POLYTECHNIC UNIVERSITY

A kit for purifying DNA by ultra-micro agarose gel and a method for purifying DNA

ActiveCN116286790BThe effect of low DNA adsorptionGood for DNA adsorptionSemi-permeable membranesMicrobiological testing/measurementPolyamidePolycarbonate membranes
This invention provides an ultra-micro agarose gel DNA purification kit and a method for purifying DNA, relating to the field of biotechnology. The kit includes: a sol solution, a purification solution, a washing solution, an elution buffer, an ion adsorption column, and a collection tube. The purification solution comprises 4-6M urea, 2-3M NaCl, and 70%-80% anhydrous ethanol. The ion adsorption column uses a double-layer nanomembrane, with the upper nanomembrane being a polycarbonate membrane and the lower nanomembrane being a polyamide membrane. The kit is low-cost and has high recovery efficiency. This invention also discloses a method for purifying DNA, using a unique buffer system and centrifugal adsorption column method, including steps such as sol-gel, purification, washing, and elution, for the recovery of DNA and PCR products from agarose gel. The method is simple, fast, has high recovery efficiency, and is safe and environmentally friendly.
Owner:NUCLEOSOME (BEIJING) BIOTECHNOLOGY CO LTD

Light-guiding glass window

A vehicle glazing (10) in which a light guide stack (22) is located between a portion of an inner transparency (26) and an outer transparency (28). The light guide stack comprises a polycarbonate film (32) joined to the transparency by PET layers (38, 40), which are secured to the polycarbonate film on one side by silicone (34, 36) and to the transparency on the other side by PVB (42, 44). The terminal ends of the extended tabs of the polycarbonate film form an edge connected to a light rod (14) so ​​that visible light propagates through the light rod and enters the polycarbonate film through the edge. The visible light propagates through etchings in the smooth surface of the polycarbonate film to form an image. When the glazing is installed in a vehicle entrance, the extension of one of the transparencies protects the polycarbonate tab and supports the light rod.
Owner:VITRO AUTOMOTIVE HOLDINGS CORPORATION

Preparation method and application of a bionic brain-targeted cyclosporine A nanocrystal drug

The present invention discloses a preparation method and application of a biomimetic brain-targeted cyclosporine A (CsA) nanoparticle crystal drug. The composition of the biomimetic brain-targeted CsA nanocrystal drug is CsA and platelet membrane (M- PLT ), and M- PLT is wrapped on the surface of CsA nanocrystals by the polycarbonate membrane extrusion method (CsA@M- PLT ), improving the stability of CsA nanocrystals and the targeting property to the brain injury site. The drug loading of CsA in CsA@M- PLT is 49.17%. After being taken up by neurons, CsA@M- PLT can restore the mitochondrial membrane potential of neurons, reduce the release of mitochondrial ROS, and inhibit the apoptosis of neuron cells; CsA@M- PLT can reduce the damage of the blood-brain barrier, reduce brain edema, and treat secondary brain injury efficiently through multiple pathways.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY

Silk / GO composite membrane, preparation method thereof and application of silk / GO composite membrane in salinity gradient power generation device

The invention discloses a silk / GO composite film, a preparation method thereof and application of the silk / GO composite film in a salinity gradient power generation device, and belongs to the technical field of functional films and preparation of the functional films. According to the invention, the problem of low salinity gradient power generation efficiency caused by limited ion transmission capability of the existing separation membrane for salinity gradient power generation is solved. Silk and graphene oxide are used as raw materials, and a polycarbonate film is used as a substrate to prepare the silk / GO composite film. According to the composite membrane, silk and graphene oxide are compounded to form a stable frame structure, so that the interface connection among nanoparticles is greatly improved, and the ion transmission behavior is also remarkably improved, so that the salinity gradient power generation device based on the seawater salinity gradient has relatively high power generation efficiency. The light source is coupled with a marine emergency rescue system, the advantages of energy of the seawater environment and the like are effectively utilized, and the prepared portable rescue lamp is expected to solve the key scientific and technical problems that marine rescue equipment is short in working time and cannot be self-powered.
Owner:HEILONGJIANG UNIV