85 results about "Polycarbonate membrane" patented technology

The invention discloses a bionic glomerulus chip. The chip is characterized in that a porous polycarbonate membrane layer is included, and an upper chip layer and a lower chip layer are fixed on the two faces of the polycarbonate membrane layer respectively and both made of polydimethylsiloxane; an upper inlet pool, a rectangular upper cell culture room and an upper outlet pool are thoroughly formed in the upper chip layer, a first channel is communicated between the upper inlet pool and the upper cell culture room, a second channel is communicated between the upper outlet pool and the upper cell culture room, the width of the first channel and the width of the upper cell culture room are both H, and the width of the second channel is h, wherein H:h=10:3; a lower inlet pool, a rectangular lower cell culture room and a lower outlet pool are thoroughly formed in the lower chip layer, a third channel is communicated between the lower inlet pool and the lower cell culture room, a fourth channel is communicated between the lower outlet pool and the lower cell culture room, and the width of the lower cell culture room, the width of the third channel, and the width of the fourth channel are all H.

The invention relates to a preparation method of an ergosterol and gefitinib combined liposome. According to the method, GEF is entrapped by an ammonium sulfate gradient method to prepare the ERG combined GEF compound lipidosome; the specific preparation method comprises the following steps: fully dissolving SPC, Chole and ERG with chloroform, performing spin-drying on a rotary evaporator, and carrying out vacuum drying to be odorless; adding pure water, and hydrating the material on a horizontal shaking table for 20-50 minutes to obtain an intermediate product; putting the intermediate product in an ice bath, and carrying out ultrasonic treatment; and finally, filtering the material by adopting a multi-stage microfiltration membrane in sequence, and finally, carrying out high-pressure extrusion by adopting a polycarbonate membrane with a thickness of 0.1 mu m. The GEF encapsulation efficiency is taken as an index, the preparation process of the ERG/GEF-LIP is optimized through singlefactor and response surface design, the form, particle size distribution, Zeta potential, in-vitro cumulative release degree and peroxide value of the ERG/GEF-LIP are preliminarily investigated, and in-vitro lung cancer resistance preliminary research is carried out on drug-resistant cells PC-9/GR.