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Determining functional status of immune cells types and immune response

A technology of immune cells and functional status, applied in the field of bioinformatics, can solve problems such as unreliability

Pending Publication Date: 2020-08-25
KONINKLJIJKE PHILIPS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, in cancer, quantification of CD8+ and CD3 / 4+ cells and staining for PD1 and PD-L1 are available to predict treatment response, however neither is reliable

Method used

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  • Determining functional status of immune cells types and immune response
  • Determining functional status of immune cells types and immune response
  • Determining functional status of immune cells types and immune response

Examples

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Embodiment Construction

[0240] The following examples merely illustrate particularly preferred methods and selected aspects related thereto. The teachings provided herein can be used to construct several tests and / or kits, e.g., for detecting, predicting, and / or diagnosing the functional state of one or more immune cell types, the adaptive immune system, the innate immune system, or the overall immune system . Furthermore, when using the methods as described herein, drug prescription can advantageously be directed, drug response prediction and monitoring of drug efficacy (and / or side effects) can be performed, drug resistance can be predicted and monitored, e.g. Tests (such as companion diagnostic tests). The following examples should not be construed as limiting the scope of the invention.

[0241] 1: Method and sample description

[0242] Using Affymetrix 2.0Plus data from the GEO dataset database (https: / / www.ncbi.nlm.nih.gov / gds / ) of samples from clinical and preclinical studies in which vario...

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Abstract

A method for determining functional status of at least one immune cell type in at least one sample of a subject comprises determining the functional status of the at least one immune cell type based on activity of at least one signaling pathway in the at least one immune cell type in the at least one sample of the subject; and optionally providing the functional status of the at least one immune cell type in the at least one sample of the subject.

Description

[0001] related application [0002] This application claims U.S. Provisional Patent Application No. 62 / 566,755, filed October 2, 2017, entitled "Immunodiagnostics" and U.S. Provisional Patent Application No. 62 / 56, filed June 12, 2018, entitled "Immunodiagnostics" Priority No. 683,710, the specification, claims and drawings of both are hereby incorporated by reference in their entirety for all purposes. technical field [0003] The present invention relates generally to the fields of bioinformatics, immunology and diagnostics, genome processing, proteome processing, and related technologies. More specifically, the present invention relates to methods for determining the functional status of at least one immune cell type in at least one sample of a subject based on the activity of at least one signaling pathway in said immune cell type. The invention also relates to methods of determining the activity state of a subject's innate or adaptive immune system based on the functiona...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883G01N33/50
CPCC12Q1/6883G01N33/5041G01N33/5047G01N33/5091G01N33/5094G01N2800/60C12Q1/6881C12Q1/6886C12Q2600/158G16B5/20G16B20/00G16B10/00G16B20/20G16B25/10G16B40/00G16H50/20G16H50/30Y10S706/924
Inventor A·R·范多恩A·范德斯托尔佩M·哈特斯坎普S·P·L·库伊佩尔斯H·纳沙贝W·F·J·费尔哈格
Owner KONINKLJIJKE PHILIPS NV