A kind of florfenicol powder that improves water solubility and its preparation method and application

The technology of florfenicol powder and florfenicol is applied in the directions of medical preparations with non-active ingredients, medical preparations containing active ingredients, powder delivery, etc. Poor water solubility of florfenicol

Active Publication Date: 2022-06-24
南京大方生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to the poor water solubility of florfenicol, it brings a lot of inconvenience to clinical medication
In addition, with the widespread use of florfenicol leading to increased bioresistance leading to poor efficacy, there is a need to address this issue

Method used

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  • A kind of florfenicol powder that improves water solubility and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] In parts by weight, 10 parts of florfenicol powder, 5 parts of citric acid, 3 parts of polyvinylpyrrolidone PVPK30, 70 parts of lactose, 2 parts of sodium lauryl sulfate, 5 parts of polyethylene glycol 6000, 2 parts of Trimethoprim lactate and 3 parts of palm oil form florfenicol powder.

[0023] A preparation method for improving water-soluble florfenicol powder, comprising the steps:

[0024] 1) Weigh 5 parts of polyethylene glycol 6000, 3 parts of palm oil, 110 parts of distilled water and dissolve 10 parts of florfenicol powder at 53 degrees Celsius to obtain mixture one;

[0025] 2) adding 3 parts of polyvinylpyrrolidone PVPK30, 70 parts of lactose, 2 parts of sodium lauryl sulfate, 2 parts of trimethoprim lactate to mixture one, stirring and dissolving under 53 degrees Celsius, then spray drying to obtain mixture two, 40 mesh sieve;

[0026] 3) Add 5 parts of citric acid to mixture 2, mix well, pass through a 40-mesh sieve, and obtain florfenicol powder.

[002...

Embodiment 2

[0029] In parts by weight, 10 parts of florfenicol powder, 4 parts of citric acid, 3 parts of polyvinylpyrrolidone PVPK30, 69 parts of lactose, 3 parts of sodium lauryl sulfate, 5 parts of polyethylene glycol 6000, 3 parts of Trimethoprim lactate and 3 parts of palm oil form florfenicol powder.

[0030] A preparation method for improving water-soluble florfenicol powder, comprising the steps:

[0031] 1) Weigh 5 parts of polyethylene glycol 6000, 3 parts of palm oil, 110 parts of distilled water and dissolve 10 parts of florfenicol powder at 53 degrees Celsius to obtain mixture one;

[0032] 2) adding 3 parts of polyvinylpyrrolidone PVPK30, 69 parts of lactose, 3 parts of sodium lauryl sulfate, 3 parts of trimethoprim lactate to mixture one, stirring and dissolving under 53 degrees Celsius, then spray drying to obtain mixture two, 40 mesh sieve;

[0033] 3) Add 4 parts of citric acid to mixture 2, mix well, pass through a 40-mesh sieve to obtain florfenicol powder.

[0034]...

Embodiment 3

[0036] In parts by weight, 10 parts of florfenicol powder, 5 parts of citric acid, 3 parts of polyvinylpyrrolidone PVPK30, 69 parts of lactose, 2 parts of sodium lauryl sulfate, 5 parts of polyethylene glycol 6000, 3 parts of Trimethoprim lactate and 3 parts of palm oil form florfenicol powder.

[0037] A preparation method for improving water-soluble florfenicol powder, comprising the steps:

[0038] 1) Weigh 5 parts of polyethylene glycol 6000, 3 parts of palm oil, 110 parts of distilled water and dissolve 10 parts of florfenicol powder at 53 degrees Celsius to obtain mixture one;

[0039] 2) adding 3 parts of polyvinylpyrrolidone PVPK30, 69 parts of lactose, 2 parts of sodium lauryl sulfate, 3 parts of trimethoprim lactate to mixture one, stirring and dissolving under 53 degrees Celsius, then spray drying to obtain mixture two, Pass through a 40-mesh sieve; 3) add 5 parts of citric acid to mixture two, mix well, pass through a 40-mesh sieve, and obtain florfenicol powder. ...

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Abstract

The invention relates to a water-soluble florfenicol powder and its preparation method and application. According to parts by weight, it consists of 10 parts of florfenicol powder, 3-5 parts of citric acid, and 2-3 parts of polyvinylpyrrolidone PVPK30, 50-60 parts of lactose, 2-4 parts of sodium lauryl sulfate, 5-7 parts of polyethylene glycol 6000, 2-3 parts of trimethoprim lactate, 2-4 parts of palm oil. The present invention uses polyethylene glycol 6000, citric acid, polyvinylpyrrolidone PVPK30, lactose, sodium lauryl sulfate, palm oil, and various components to synergistically improve the water solubility of florfenicol and trimethoprim lactate, to maximize its efficacy.

Description

technical field [0001] The invention relates to a florfenicol powder with improved water solubility and a preparation method and application thereof. Background technique [0002] Florfenicol Chinese name: Florfenicol; Florfenicol; Florfenicol, is a synthetic monofluoro derivative of thiamphenicol, white or off-white crystalline powder, odorless. Very slightly soluble in water and chloroform, slightly soluble in glacial acetic acid, soluble in methanol and ethanol. It is a new broad-spectrum antibiotic of chloramphenicol for veterinary use, which was successfully developed in the late 1980s. It is an animal-specific antibacterial drug, used for bacterial diseases of pigs, chickens and fish caused by sensitive bacteria, especially for respiratory system infections and intestinal infections. [0003] Due to the poor water solubility of florfenicol, it brings a lot of inconvenience to clinical medication. Furthermore, with the widespread use of florfenicol leading to increas...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K31/165A61K31/505A61K47/32A61K47/12A61K47/44A61K47/26A61K47/10A61P31/04
CPCA61K31/165A61K31/505A61K9/146A61K9/145A61P31/04A61K2300/00
Inventor 汤法银
Owner 南京大方生物工程有限公司
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