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Docetaxel injection storage device and preparation method thereof

A docetaxel and storage device technology, which is applied in the field of medical medicine, can solve the problems of slow dissolution speed, large concentration error of the finished drug solution, and easy generation of bubbles, etc., to accelerate the dissolution speed, prevent physical and chemical reactions, and improve stirring efficiency Effect

Pending Publication Date: 2020-09-01
WUHU NO 2 PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to provide a kind of docetaxel injection storage device and preparation method thereof, to solve the docetaxel injection that occurs during clinical use in the above-mentioned background technology that the dissolution rate is slow, bubbles are easily generated, and it is very difficult to It is difficult to dissolve the docetaxel powder in the vial, which leads to large concentration errors of the finished drug solution and increases the hidden dangers of drug use.

Method used

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  • Docetaxel injection storage device and preparation method thereof
  • Docetaxel injection storage device and preparation method thereof
  • Docetaxel injection storage device and preparation method thereof

Examples

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Embodiment 1

[0022] see Figure 1-3 , the present invention provides a technical solution: an optimized docetaxel injection storage device, comprising a vial main body 1, the inner wall of the opening of the vial main body 1 is plugged with a butyl rubber stopper 2, and the inside of the vial main body 1 is filled with Oily docetaxel injection and butyl rubber vibrator3.

[0023] The butyl rubber vibrator 3 is symmetrically installed with protrusions 4 on both sides near the upper end, the two sets of protrusions 4 are cylindrical in shape, and the surface of the butyl rubber vibrator 3 is covered with an inert film;

[0024] Through the above technical scheme: since the docetaxel powder in the vial main body 1 has a butyl rubber vibrator 3, after injecting the solvent, during the shaking process, the butyl rubber vibrator 3 shakes up and down, and the resistance of the docetaxel solution Under the action, the protrusion 4 is continuously stirred, so that the docetaxel powder in the vial ...

Embodiment 2

[0026] A preparation method of an optimized docetaxel injection, the specific steps of the preparation method are as follows:

[0027] Step 1: Select solvent according to clinical needs;

[0028] Step 2: Accurately extract the corresponding volume of solvent with a syringe during preparation according to the volume required to fill the vial indicated on the label of the vial;

[0029] Step 3: Control the syringe handle, insert the syringe needle into the butyl rubber stopper of the opening of the vial, let the solvent in the syringe flow into the vial slowly until the space in the vial is completely filled with solvent, which can prevent the generation of air bubbles during shaking;

[0030] Step 4: Shake the vial filled with solvent with a vibrator or manually, and shake and stir the butyl rubber vibrator in the solution in the vial until the docetaxel powder is completely dissolved in the solvent;

[0031] Step 5: Adjust the dissolved docetaxel solution to the use concentra...

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Abstract

The invention discloses a docetaxel injection storage device, which comprises a penicillin bottle body, a butyl rubber plug is plugged into the inner wall of an opening of the penicillin bottle body,and the penicillin bottle body is filled with oily docetaxel injection and a butyl rubber vibrator. According to the storage device and the preparation method thereof, the penicillin bottle space needs to be fully filled with a solvent by preparation personnel in the preparation process; therefore, bubbles can be prevented from being generated during oscillation, the dissolving speed of the docetaxel injection in the solvent can be increased, and the situation that the drug effect of the docetaxel injection is affected due to the fact that the drug and the butyl rubber vibrator carry out physical and chemical reactions is prevented.

Description

technical field [0001] The invention relates to the technical field of medical drugs, in particular to a docetaxel injection storage device and a preparation method thereof. Background technique [0002] Docetaxel (docetaxel) is a cycle-specific antineoplastic drug in the M phase. It has good curative effect on advanced breast cancer, ovarian cancer and non-small cell lung cancer. It is effective on head and neck cancer, pancreatic cancer, small cell lung cancer, gastric cancer , melanoma and soft tissue sarcoma also have a certain curative effect, and are widely used clinically, but due to its large adverse reactions and high requirements for the concentration of the drug solution when used, this makes its clinical application subject to many restrictions; [0003] The storage method used for docetaxel injection currently on the market is to mix the raw material drug with polysorbate 80 according to a certain ratio and put it into a vial, and then mix it with water for inje...

Claims

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Application Information

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IPC IPC(8): A61J1/06A61J1/20B01F11/00B01F1/00
CPCA61J1/062A61J1/2096B01F21/02B01F31/20
Inventor 刘智刚刘秦朝阳刘信奕
Owner WUHU NO 2 PEOPLES HOSPITAL
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